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Ob1, the first commmon obesity gene was located on chromosome 10
November 16, 1998Each family has at least one member whose body mass index (BMI, the ratio of the weight in kg to the surface of the body in m2; normal BMI is below 25) is higher than 40 and at least one other member whose BMI is over 27. 380 genetic markers, covering 23 pairs of chromosomes, were studied in order to find genetic similarities between the obese members of these families. Genetic analysis showed a very high correlation between obesity and the ob1 gene (the probability of such a correlation is 100,000 to 1). The ob1 gene can probably explain the 1/3 genetic risk of obesity in the French population. Two other chromosome regions, located on chromosomes 2 and 5 (1p1 and 1p2) influence the leptin rate, a hormone produced by fat tissue, which controls appetite and energy expenditure.
This is the first time a gene playing a major role in common obesity - a disease which affects 8% of the French population - is located. This discovery will make it possible, once the ob1 gene is identified, to understand the molecular basis of common obesity. Since 1997, several genes responsible for very severe, but rare monogenic forms of obesity have been identified, such as the leptin gene, the leptin receptor and the MC4 receptor. These genes, however, do not seem to play an important part in common polygenic forms of obesity. In 1995, the CNRS EP 10 team had shown that the beta-3 adrenergic receptor could play a role in obesity, but that this role was minor.
The discovery of the genetic factors responsible for common forms of obesity will lead to the development of new medication to treat this disease. In March 1998, an agreement was signed between the CNRS, the University of Columbia in New York, the British Diabetic Association and the Eli-Lilly pharmaceutical society. The aim of this agreement is to determine targets for the development of new drugs. These findings represent the first successful outcome of this international collaboration
CNRS (Délégation Ile-de-France Ouest & Nord)
Obesity Current Events and Obesity News RSSFat around the middle increases the risk of dementia
Women who store fat on their waist in middle age are more than twice as likely to develop dementia when they get older, reveals a new study from the Sahlgrenska Academy.
Other Illnesses, Body Weight Do Not Explain Racial Disparities in Colon Cancer Survival, UAB Researchers Say
A new study by University of Alabama at Birmingham (UAB) researchers shows that body-mass index (BMI) and co-existing medical conditions (co-morbidity) do not explain the decreased survival observed among African-Americans compared to Caucasians who also have colon cancer.
Diabetes surgery summit consensus lays foundation for new field of medicine
A first-of-its-kind consensus statement on diabetes surgery is published online today in the Annals of Surgery.
Daycare may double TV time for young children, study finds
In a new study, the amount of television viewed by many young children in child care settings doubles the previous estimates of early childhood screen time, with those in home-based settings watching significantly more on average than those in center-based daycares.
Patient's weight not linked to success of fibroid surgery
Obese patients are no more likely to have post-operative complications than those of average weight when undergoing robotic surgery to remove uterine fibroids, according to a study at Henry Ford Hospital.
Scripps research scientists find new link between insulin and core body temperature
A team led by scientists at The Scripps Research Institute have discovered a direct link between insulin-a hormone long associated with metabolism and metabolic disorders such as diabetes-and core body temperature.
Night Beat, Overtime and a Disrupted Sleep Pattern Can Harm Officers' Health
A police officer who works the night shift, typically from 8 p.m. to 4 a.m., already is at a disadvantage when it comes to getting a good "night's" sleep.
Fat collections linked to decreased heart function
Researchers from Boston University School of Medicine (BUSM) have shown that fat collection in different body locations, such as around the heart and the aorta and within the liver, are associated with certain decreased heart functions.
Teens' mental health affects how long they stay in school, new study shows
Queen's University researcher Steven Lehrer has won a prestigious international award in recognition of his contributions to health economics.
Playing sport up to the end of pregnancy is healthy for the baby and the mother
Contrary to more conservative customs, exercising up to the end of pregnancy has no harmful effect on the weight or size of the foetus.
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