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New finding in studying dopamine transporter
June 07, 2005New Haven, Conn.-Confirming findings in a previous study, Yale researchers observed an altered availability of the dopamine transporter in healthy persons with a genetic variation linked to substance abuse and attention deficit hyperactivity disorder (ADHD).
"Healthy people who carry a particular variant of the dopamine transporter gene, the nine repeat allele, have significantly higher levels of dopamine transporter in the brain," said the lead author, Christopher van Dyck, M.D., associate professor of psychiatry and neurobiology and director of the Alzheimer's Disease Research Unit and the Cognitive Disorders Clinic in the Department of Psychiatry.
The new study included 96 healthy European Americans-54 men and 42 women-who underwent a clinical examination to exclude any neurological or psychiatric disease, alcohol abuse or substance abuse. The levels of dopamine transporter availability were measured using SPECT imaging, and the dopamine transporter genotypes were determined by co-author Joel Gelernter, M.D.
"We are not yet sure if the effects of the variant on transporter levels in our healthy subjects can be generalized to neuropsychiatric disorders," van Dyck said. "If they can be, our results may be relevant for substance abuse, tobacco smoking, and ADHD. "The results suggest that the mechanism of association of this gene with several disorders could be altered levels of central dopamine transporter protein, influencing concentrations of extracellular dopamine.
This study replicated and expanded on a preliminary report by Leslie Jacobsen, M.D., and colleagues at Yale, although other studies of the effects of this variation on the availability of the dopamine transporter have yielded contradictory results.
In addition to Jacobsen and Gelernter, co-authors included Robert Malison, M.D., John Seibyl, M.D., Julie Staley, Marc Laruelle, M.D., Ronald Baldwin, and Robert Innis, M.D. The study was supported by grants and funds from the American Federation for Aging Research; Rose and Philip Hoffer; the Department of Veterans Affairs; the National Institute of Mental Health, and the National Institute on Drug Abuse.
Yale University
"We are not yet sure if the effects of the variant on transporter levels in our healthy subjects can be generalized to neuropsychiatric disorders," van Dyck said. "If they can be, our results may be relevant for substance abuse, tobacco smoking, and ADHD. "The results suggest that the mechanism of association of this gene with several disorders could be altered levels of central dopamine transporter protein, influencing concentrations of extracellular dopamine.
This study replicated and expanded on a preliminary report by Leslie Jacobsen, M.D., and colleagues at Yale, although other studies of the effects of this variation on the availability of the dopamine transporter have yielded contradictory results.
In addition to Jacobsen and Gelernter, co-authors included Robert Malison, M.D., John Seibyl, M.D., Julie Staley, Marc Laruelle, M.D., Ronald Baldwin, and Robert Innis, M.D. The study was supported by grants and funds from the American Federation for Aging Research; Rose and Philip Hoffer; the Department of Veterans Affairs; the National Institute of Mental Health, and the National Institute on Drug Abuse.
Yale University
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Dopamine Transporters: Chemistry, Biology, and Pharmacology (Wiley Series in Drug Discovery and Development) by Mark L. Trudell (Editor), Sari Izenwasser (Editor), Binghe Wang (Editor) Understanding the dopamine transporter can lead to new therapies for neurological disorders This book consolidates current information on the dopamine transporter (DAT) in relationto medicinal chemistry and synthesis, biology and pathology, and pharmacology. Because of DAT's role in diseases such as Parkinson's, schizophrenia, attention deficit hyperactivity disorder (ADHD), Tourette syndrome, and drug abuse (in particular, cocaine addiction), DAT research is an exploding field. Tremendous advances have been made toward understanding how it impacts a variety of neurological disease states and disorders. |
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Dopamine Receptors And Transporters: Function, Imaging And Clinical Implication (Neurological Disease and Therapy) (v. 56) by Anita Sidhu (Editor), Marc Laruelle (Editor), Philippe Vernier (Editor) , Georgetown Univ., Washington D.C. Text presents updated information on the basic and clinical advances in the field. Focuses on the clinical application of treating dopamine-linked diseases such as Parkinson's disease, Tourette's syndrome, and attention hyperactivity disorder. Previous edition: 1994. |
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Distribution of the 3' VNTR Polymorphism in the Human Dopamine Transporter Gene in World Populations.: An article from: Human Biology by R.j. Mitchell (Author), S. Howlett (Author), L. Earl (Author), N.g. White (Author), J. Mccomb (Author), M.s. Schanfield (Author), I. Briceno (Author), S.s. Papiha (Author), L. Osipova (Author), G. Livshits (Author), W.r. Leonard (Author), M.h. Crawford (Author) This digital document is an article from Human Biology, published by Wayne State University Press on April 1, 2000. The length of the article is 4403 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Distribution of the 3' VNTR Polymorphism in the Human Dopamine Transporter Gene in World Populations. Author: R.j. Mitchell Publication: Human Biology (Refereed) Date: April 1, 2000 Publisher: Wayne State University Press Volume: 72 Issue: 2 Page: 295 Distributed by Thomson... | |
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Characterization of photoaffinity labeled proteolytic fragments from cloned human dopamine transporter. (Professional Communications).(Brief Article): ... of the North Dakota Academy of Science by Margaret Jean Lowe (Author), Roxanne A. Vaughan (Author) This digital document is an article from Proceedings of the North Dakota Academy of Science, published by North Dakota Academy of Science on April 1, 2000. The length of the article is 594 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Characterization of photoaffinity labeled proteolytic fragments from cloned human dopamine transporter. (Professional Communications).(Brief Article) Author: Margaret Jean Lowe Publication: Proceedings of the North Dakota Academy of Science (Refereed) Date: April 1, 2000 Publisher: North Dakota Academy of Science Page:... | |
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Purification of a photoaffinity labeled proteolytic fragment from cloned human dopamine transporter. (Professional Communications).(Brief Article): An ... of the North Dakota Academy of Science by Margaret Jean Lowe (Author), Roxanne A. Vaughan (Author) This digital document is an article from Proceedings of the North Dakota Academy of Science, published by North Dakota Academy of Science on April 1, 2001. The length of the article is 561 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Purification of a photoaffinity labeled proteolytic fragment from cloned human dopamine transporter. (Professional Communications).(Brief Article) Author: Margaret Jean Lowe Publication: Proceedings of the North Dakota Academy of Science (Refereed) Date: April 1, 2001 Publisher: North Dakota Academy of Science Page:... | |
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