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Scientists help develop first single molecule transistor
June 07, 2005
A scientist at the University of Liverpool has helped to create the world's smallest transistor-by proving that a single molecule can power electric circuits A scientist at the University of Liverpool has helped to create the world's smallest transistor-by proving that a single molecule can power electric circuits.
Dr Werner Hofer, from the University's Surface Science Research Centre, is one of an international team of scientists who have created a prototype that demonstrates a single charged atom on a silicon surface can regulate the conductivity of a nearby molecule. Computers and other technology based on this concept would require much less energy to power, would produce much less heat, and run much faster.
Currently, most electronic devices are based on silicon. There is, however, a limit to how many transistors can be packed into a given volume of silicon as the currents in these transistors are high and can overheat. By miniaturizing a transistor, the time during which an electron can pass through it is reduced and therefore the device can be operated with much higher frequencies and take up much less space.
Dr Hofer, a theorist, who worked in collaboration with colleagues from the National Institute for Nanotechnology of the National Research Council in Canada and the University of Alberta, provided the theoretical background in an experiment to examine the potential for electrical transistors on a much smaller, molecular scale. Their findings have been published in the journal, Nature.
Molecules are extremely small, on the scale of a nanometre (one billionth of a metre). The team tested the transistor potential of a molecule by using the electrostatic field emanating from a single atom to regulate the conductivity of a molecule, allowing an electric current to flow through the molecule. These effects were easily observed at room temperature, in contrast to previous molecular experiments that had to be conducted at temperatures close to absolute zero, and with much smaller current amplification. Dr Hofer explains: "Our experiments demonstrate that we can control the current through a single molecule by charging a single atom on a silicon surface, while all surrounding atoms remain neutral.
"Our research brings us a step nearer to using molecular electronics which would not only prove more efficient and cheaper than current devices, but would also have the potential to power green technology because of the biodegradable nature of the device."
He added: "Our prototype is a scientific breakthrough in molecular electronics. We have successfully shown the potential for devices of unheard-of smallness and unheard-of efficiency. This is the first time anyone has shown that a molecule is in fact a transistor.\
University of Liverpool
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Handbook of Single Molecule Fluorescence Spectroscopy
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Analytical measurements at the single molecule level under ambient conditions have become almost routine in the past few years. The application of this technology to fundamental studies of heterogeneity in biomolecular structure and dynamics, chemical and biological reaction kinetics and photophysics provides a rich playground for molecular scientists. The potential use of single molecule detection for nanotechnology and quantum information processing is a new and almost unexplored area. This handbook is intended for those interested in a practical introduction to single molecule investigations using fluorescence techniques and places special emphasis on the practicalities of achieving single molecule resolution, analyzing the resulting data and exploration of the applications in...
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As molecular and cellular biologists move toward nano techniques for performing experiments on single molecules rather than on populations of molecules, a comprehensive manual on how (and why) to carry out such experiments is needed. Single-Molecule Techniques: A Laboratory Manual fills this requirement--it is the first to take researchers who know nothing about single molecule analyses to the point where they can successfully design and execute appropriate experiments. Geared toward research scientists in structural and molecular biology, biochemistry, and biophysics, the manual will be useful to all who are interested in observing, manipulating, and elucidating the molecular mechanisms and discrete properties of macromolecules. Techniques range from in vivo and in vitro fluorescent...
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Theory and Evaluation of Single-Molecule Signals
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This book reviews recently developed theoretical and numerical approaches to deal with optical and mechanical signals from individual molecules. The character of data generated by single molecules, and more generally by single nano-objects, qualitatively differs from those obtained in conventional experiments on large ensembles of molecules. Fluctuations, randomness and irreproducibility are central to single-molecule measurements, and the specific methods required to extract reliable and statistically relevant information from them are presented here. With contributions mainly from participants of the Theory, Modeling and Evaluation of Single-Molecule Measurements workshop held in Leiden, the Netherlands, on April 16 20, 2007, this book is an authoritative compendium on the...
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Single Molecule Biology
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Single molecule techniques, including single molecule fluorescence, optical tweezers, and scanning probe microscopy, allow for the manipulation and measurement of single biological molecules within a live cell or in culture. These approaches, amongst the most exciting tools available in biology today, offer powerful new ways to elucidate biological function, both in terms of revealing mechanisms of action on a molecular level as well as tracking the behaviour of molecules in living cells. This book provides the first complete and authoritative treatment of this rapidly emerging field, explicitly from a biological perspective.
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Single Molecule
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![Molecules [12" Club Vinyl Single]](http://ecx.images-amazon.com/images/I/215iiq8degL._SL160_.jpg)
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Molecules [12" Club Vinyl Single]
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Single-Molecule Optical Detection, Imaging and Spectroscopy
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Presents the latest developments in detecting and probing single entities. A thorough yet concise survey of current methods and their applications are included.
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Handbook of Single-Molecule Biophysics
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An overview of current research and developments in ultrasensitive bioanalysis New platforms of ultrasensitive analysis of biomolecules and single living cells using multiplexing, single nanoparticle sensing, nano-fluidics, and single-molecule detection are advancing every scientific discipline at an unprecedented pace. With chapters written by a diverse group of scientists working in the forefront of ultrasensitive bioanalysis, this book provides an overview of the current status and an in-depth understanding of the objectives and future research directions of ultrasensitive bioanalysis. Spanning a wide spectrum of new research approaches, this book: Introduces new theories, ideas, methodologies, technologies, and applications of ultrasensitive bioanalysis in a wide...
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