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Mount Sinai Hospital researcher develops Canada's first embryonic stem cell lines
June 08, 2005A senior scientist at Mount Sinai Hospital has developed Canada's first two human embryonic stem cell lines, giving researchers across the country new potential and hope for eventually discovering treatments and cures for many chronic and fatal diseases.
"My hope - and the hope of my world-class laboratory team - is that our step of developing the first Canadian embryonic stem cell lines will ultimately bring Canada and the world closer to treating or curing diseases such as Multiple Sclerosis, Parkinson's Disease, Alzheimer's Disease, Diabetes and spinal cord injuries," said Dr. Andras Nagy, a researcher at Mount Sinai's Samuel Lunenfeld Research Institute.
"Our research remains in an early phase but the ability of these cells to develop into any kind of function cells in adult bodies holds enormous promise for these cells to regenerate damaged tissues that cause incurable diseases."
The Canadian Institutes of Health Research's Stem Cell Oversight Committee (SCOC) determined that Dr. Nagy derived these new stem cells lines in a manner consistent with the Stem Cell Guidelines.
The two cell lines have since been submitted to, and approved by, the International Stem Cell Initiative (ISCI). The use of the two new lines in Canada will be directed by the Stem Cell Network. The McLaughlin Centre for Molecular Medicine at the University of Toronto contributes to the support of a human embryonic stem cell core facility.
The stem cell lines will be freely available to the Canadian scientific community and will enable Canadian scientists to research potential treatments for a variety of diseases.
"Having our own cell lines gives Canadian researchers access to a valuable research tool. These two lines will be shared with scientists all over Canada and with the scientific community at large. They are a valuable contribution to stem cell research on a global scale," said Dr. Michael Rudnicki, Scientific Director of the Stem Cell Network.
Dr. Nagy is a senior scientist at the Samuel Lunenfeld Research Institute at Mount Sinai Hospital in Toronto. He is also a professor in the department of Medical Genetics and Microbiology at the University of Toronto. In 1974 Dr. Nagy completed his B.A. (M.A.) in Mathematics and in 1979 completed his Ph.D. in Genetics both at Lorand Eötvös University Budapest. Dr. Nagy currently holds the Canadian Institute of Health Records Senior Scientist Award 2002-2007.
University of Toronto
The Canadian Institutes of Health Research's Stem Cell Oversight Committee (SCOC) determined that Dr. Nagy derived these new stem cells lines in a manner consistent with the Stem Cell Guidelines.
The two cell lines have since been submitted to, and approved by, the International Stem Cell Initiative (ISCI). The use of the two new lines in Canada will be directed by the Stem Cell Network. The McLaughlin Centre for Molecular Medicine at the University of Toronto contributes to the support of a human embryonic stem cell core facility.
The stem cell lines will be freely available to the Canadian scientific community and will enable Canadian scientists to research potential treatments for a variety of diseases.
"Having our own cell lines gives Canadian researchers access to a valuable research tool. These two lines will be shared with scientists all over Canada and with the scientific community at large. They are a valuable contribution to stem cell research on a global scale," said Dr. Michael Rudnicki, Scientific Director of the Stem Cell Network.
Dr. Nagy is a senior scientist at the Samuel Lunenfeld Research Institute at Mount Sinai Hospital in Toronto. He is also a professor in the department of Medical Genetics and Microbiology at the University of Toronto. In 1974 Dr. Nagy completed his B.A. (M.A.) in Mathematics and in 1979 completed his Ph.D. in Genetics both at Lorand Eötvös University Budapest. Dr. Nagy currently holds the Canadian Institute of Health Records Senior Scientist Award 2002-2007.
University of Toronto
Stem Cell Current Events and Stem Cell News RSSGene mismatch influences success of bone marrow transplants
A commonly inherited gene deletion can increase the likelihood of immune complications following bone marrow transplantation, an international team of researchers reports in the November 22 advance online issue of Nature Genetics.
New research shows versatility of amniotic fluid stem cells
For the first time, scientists have demonstrated that stem cells found in amniotic fluid meet an important test of potential to become specialized cell types, which suggests they may be useful for treating a wider array of diseases and conditions than scientists originally thought.
First reconstitution of an epidermis from human embryonic stem cells
Stem cell research is making great strides. This is yet again illustrated by a study carried out by the I-STEM* Institute (I-STEM/ Inserm UEVE U861/AFM), published in the Lancet on 21 November 2009. The I-STEM team, directed by Marc Peschanski has just succeeded in recreating a whole epidermis from human embryonic stem cells.
Your Own Stem Cells Can Treat Heart Disease
The largest national stem cell study for heart disease showed the first evidence that transplanting a potent form of adult stem cells into the heart muscle of subjects with severe angina results in less pain and an improved ability to walk. The transplant subjects also experienced fewer deaths than those who didn't receive stem cells.
U of M researchers find 2 units of umbilical cord blood reduce risk of leukemia recurrence
A new study from the Masonic Cancer Center, University of Minnesota shows that patients who have acute leukemia and are transplanted with two units of umbilical cord blood (UCB) have significantly reduced risk of the disease returning.
Researchers find potential treatment for Huntington's disease
Investigators at Burnham Institute for Medical Research (Burnham), the University of British Columbia's Centre for Molecular Medicine and Therapeutics and the University of California, San Diego have found that normal synaptic activity in nerve cells (the electrical activity in the brain that allows nerve cells to communicate with one another) protects the brain from the misfolded proteins associated with Huntington's disease.
Researchers 'notch' a victory toward new kind of cancer drug
Scientists have devised an innovative way to disarm a key protein considered to be "undruggable," meaning that all previous efforts to develop a drug against it have failed.
UCI embryonic stem cell therapy restores walking ability in rats with neck injuries
The first human embryonic stem cell treatment approved by the FDA for human testing has been shown to restore limb function in rats with neck spinal cord injuries - a finding that could expand the clinical trial to include people with cervical damage.
First use of antibody and stem cell transplantation to successfully treat advanced leukemia
For the first time, researchers at Fred Hutchinson Cancer Research Center have reported the use of a radiolabeled antibody to deliver targeted doses of radiation, followed by a stem cell transplant, to successfully treat a group of leukemia and pre-leukemia patients for whom there previously had been no other curative treatment options.
Immune therapy can protect against or treat later lymphoma
Specially developed immune system cells that target the common Epstein-Barr virus can protect immune-suppressed bone marrow transplant recipients against lymph system disease and cancers that arise from the viral infection.
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