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Printer Friendly Print A molecule impedes the destruction of the 'Brucella' bacteria

A molecule impedes the destruction of the 'Brucella' bacteria

June 15, 2005

Research carried out with the participation of the University of Navarra has shown how a determinate molecule helps an important pathogen, Brucella abortus, escape destruction within the cells charged with eliminating infectious agents (macrophages). This research has been published in Nature Immunology scientific magazine.

Brucella is a model of an intracellular parasite, a category that includes other important bacteria, such as those of tuberculosis or legionelosis. Brucella penetrates the macrophages within membranous vesicles that are not fused with lysosomes (structures containing cellular products necessary to destroy bacteria) as occurs in other micro-organisms. On the contrary, they reach certain compartments within the macrophage. Here the bacteria multiply and establish a chain of events that determine the illness.




Brucellosis, the illness caused by these bacteria, is of great importance worldwide, with millions of human beings and domestic animals affected. This discovery not only means new useful ideas for other researchers, but also the enhanced knowledge of a very important pathogen. From this knowledge useful products, such as new vaccines, can be derived.

Elhuyar Fundazioa



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Citation Details
Title: Brucella glomerulonephritis.(Editorial)
Author: Fahim Zaman
Publication: Southern Medical Journal (Magazine/Journal)
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Publisher: Thomson Gale
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Citation Details
Title: A case of brucella spondylodiscitis with extended, multiple-level involvement.(Case Report)
Author: Mehmet Ozden
Publication: Southern Medical Journal (Refereed)
Date: February 1, 2005
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