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A molecule impedes the destruction of the 'Brucella' bacteria
June 15, 2005Research carried out with the participation of the University of Navarra has shown how a determinate molecule helps an important pathogen, Brucella abortus, escape destruction within the cells charged with eliminating infectious agents (macrophages). This research has been published in Nature Immunology scientific magazine.
Brucella is a model of an intracellular parasite, a category that includes other important bacteria, such as those of tuberculosis or legionelosis. Brucella penetrates the macrophages within membranous vesicles that are not fused with lysosomes (structures containing cellular products necessary to destroy bacteria) as occurs in other micro-organisms. On the contrary, they reach certain compartments within the macrophage. Here the bacteria multiply and establish a chain of events that determine the illness.
Brucellosis, the illness caused by these bacteria, is of great importance worldwide, with millions of human beings and domestic animals affected. This discovery not only means new useful ideas for other researchers, but also the enhanced knowledge of a very important pathogen. From this knowledge useful products, such as new vaccines, can be derived.
Elhuyar Fundazioa
Elhuyar Fundazioa
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Nasty bacteria need sunlight to do their worst
Certain types of bacteria have sunlight-sensing molecules similar to those found in plants, according to a new study. Surprisingly, at least one species-responsible for causing the flu-like disorder Brucellosis-needs light to maximize its virulence. The work suggests an entirely new model for bacterial virulence based on light sensitivity.
Improvement of the treatments against brucellosis and ovine salmonella
Maite Estevan Muguerza, a researcher of the University of Navarra, has improved existing treatments against brucellosis and sheep salmonella, by applying, in her doctoral thesis, techniques of micro- and nano-technology which permit the encapsulation of vaccines.
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