 |
|
Pomegranate juice for moms may help babies resist brain injury
June 28, 2005St. Louis, June 28, 2005 - Expectant mothers at risk of premature birth may want to consider drinking pomegranate juice to help their babies resist brain injuries from low oxygen and reduced blood flow, a new mouse study from Washington University School of Medicine in St. Louis suggests.
In humans, decreased blood flow and oxygen to the infant brain is linked to premature birth and other irregularities during pregnancy, birth and early development. The phenomenon, which is called hypoxia ischemia, causes brain injury in approximately 2 of every 1,000 full-term human births and in a very high percentage of babies born before 34 weeks of gestation. Hypoxic ischemic brain injury can lead to seizures, a degenerative condition known as hypoxic ischemic encephalopathy, and mobility impairments including cerebral palsy.
When scientists temporarily lowered brain oxygen levels and brain blood flow in newborn mice whose mothers drank water mixed with pomegranate concentrate, their brain tissue loss was reduced by 60 percent in comparison to mice whose mothers drank sugar water or other fluids.
"Hypoxic ischemic brain injury in newborns is very difficult to treat, and right now there's very little we can do to stop or reverse its consequences," explains senior author David Holtzman, M.D., the Andrew B. and Gretchen P. Jones Professor and head of the Department of Neurology. "Most of our efforts focus on stopping it when it happens, but if we could treat everyone who's at risk preventively, we may be able to reduce the impacts of these kinds of injuries."
The study, which appears in the June issue of Pediatric Research, was conducted in collaboration with POM Wonderful, a U.S. producer of pomegranates and pomegranate juice, and scientists at the University of California, Los Angeles. Lead author David Loren, M.D., formerly a neonatal critical care fellow in the Department of Pediatrics, performed the research. He is now at the University of Washington in Seattle.
Holtzman's lab has been studying neonatal brain injury for more than a decade by temporarily reducing oxygen levels and blood flow in the brains of 7-day-old mouse and rat pups. The model produces brain injuries similar to those seen in human infants injured by hypoxia ischemia.
Pomegranates contain very high concentrations of polyphenols, substances also found in grapes, red wine, and berries that scientists have linked to potential neuroprotective and anti-aging effects.
Scientists gave pregnant female mice water with pomegranate juice, plain water, sugar water or vitamin C water to drink during the last third of pregnancy and while they suckled their pups for seven days after birth.
After performing the procedures that exposed mouse pups to low oxygen levels, scientists examined the brains, comparing damage to the cortex, hippocampus and the striatum. Researchers who conducted the examinations were unaware of what the pup's mother drank. Mice whose mothers drank pomegranate juice had brain injuries less than half the size of those found in other mice.
Much of the damage from hypoxia ischemia results when oxygen-starved brain cells self-destruct via a process known as apoptosis. Scientists found an enzyme linked to apoptosis, caspase-3, was 84 percent less active in mice whose mothers drank pomegranate juice.
Holtzman says the results suggest the need for studies of pomegranate juice's effects in humans, but he cautions that because of the relative unpredictability of hypoxia ischemia in newborns, it would be difficult to assemble a sufficiently large study group.
Hypoxic ischemic brain damage is frequently associated with premature delivery. The lungs, brain and circulatory systems in some premature babies are insufficiently mature to supply the brain with enough nutrients and oxygen outside the womb. Scientists know some of the factors that increase risk of premature birth, including diabetes, low economic status, youthful mothers, weakness in the cervix and a personal or familial history of miscarriage.
"One might advise this group that studies in animals have suggested drinking pomegranate juice may reduce the risk of injury from hypoxia ischemia," he says.
Holtzman's findings and other research into the potentially beneficial effects of pomegranate juice, red wine, and other natural foods form a neurological parallel to chemoprevention, an area of oncology research focused on finding naturally-occurring substances in foods that reduce the chances of developing cancer.
"For pregnant women previously interested in the neuroprotective effects of red wine, these results suggest that pomegranate juice may provide an alternative during pregnancy, when alcohol consumption is unacceptable because it increases risk of birth defects," Holtzman says.
Holtzman's group is attempting to isolate the neuroprotective ingredients in pomegranate juice as a possible prelude to concentrating those ingredients and testing their ability to reduce brain injury. They also plan to investigate the possibility that polyphenols from pomegranates and other natural foods can slow other neurological disorders including Alzheimer's disease.
Washington University School of Medicine
"Hypoxic ischemic brain injury in newborns is very difficult to treat, and right now there's very little we can do to stop or reverse its consequences," explains senior author David Holtzman, M.D., the Andrew B. and Gretchen P. Jones Professor and head of the Department of Neurology. "Most of our efforts focus on stopping it when it happens, but if we could treat everyone who's at risk preventively, we may be able to reduce the impacts of these kinds of injuries."
The study, which appears in the June issue of Pediatric Research, was conducted in collaboration with POM Wonderful, a U.S. producer of pomegranates and pomegranate juice, and scientists at the University of California, Los Angeles. Lead author David Loren, M.D., formerly a neonatal critical care fellow in the Department of Pediatrics, performed the research. He is now at the University of Washington in Seattle.
Holtzman's lab has been studying neonatal brain injury for more than a decade by temporarily reducing oxygen levels and blood flow in the brains of 7-day-old mouse and rat pups. The model produces brain injuries similar to those seen in human infants injured by hypoxia ischemia.
Pomegranates contain very high concentrations of polyphenols, substances also found in grapes, red wine, and berries that scientists have linked to potential neuroprotective and anti-aging effects.
Scientists gave pregnant female mice water with pomegranate juice, plain water, sugar water or vitamin C water to drink during the last third of pregnancy and while they suckled their pups for seven days after birth.
After performing the procedures that exposed mouse pups to low oxygen levels, scientists examined the brains, comparing damage to the cortex, hippocampus and the striatum. Researchers who conducted the examinations were unaware of what the pup's mother drank. Mice whose mothers drank pomegranate juice had brain injuries less than half the size of those found in other mice.
Much of the damage from hypoxia ischemia results when oxygen-starved brain cells self-destruct via a process known as apoptosis. Scientists found an enzyme linked to apoptosis, caspase-3, was 84 percent less active in mice whose mothers drank pomegranate juice.
Holtzman says the results suggest the need for studies of pomegranate juice's effects in humans, but he cautions that because of the relative unpredictability of hypoxia ischemia in newborns, it would be difficult to assemble a sufficiently large study group.
Hypoxic ischemic brain damage is frequently associated with premature delivery. The lungs, brain and circulatory systems in some premature babies are insufficiently mature to supply the brain with enough nutrients and oxygen outside the womb. Scientists know some of the factors that increase risk of premature birth, including diabetes, low economic status, youthful mothers, weakness in the cervix and a personal or familial history of miscarriage.
"One might advise this group that studies in animals have suggested drinking pomegranate juice may reduce the risk of injury from hypoxia ischemia," he says.
Holtzman's findings and other research into the potentially beneficial effects of pomegranate juice, red wine, and other natural foods form a neurological parallel to chemoprevention, an area of oncology research focused on finding naturally-occurring substances in foods that reduce the chances of developing cancer.
"For pregnant women previously interested in the neuroprotective effects of red wine, these results suggest that pomegranate juice may provide an alternative during pregnancy, when alcohol consumption is unacceptable because it increases risk of birth defects," Holtzman says.
Holtzman's group is attempting to isolate the neuroprotective ingredients in pomegranate juice as a possible prelude to concentrating those ingredients and testing their ability to reduce brain injury. They also plan to investigate the possibility that polyphenols from pomegranates and other natural foods can slow other neurological disorders including Alzheimer's disease.
Washington University School of Medicine
Researcher Focuses on Pros, Cons of Antioxidants from Fruits and Vegetables
Nutrition: It's not just the four basic food groups any more. Researcher Dr. Susanne Mertens-Talcott of Texas A&M University is looking into how plant-based phytochemicals, including antioxidants and herbal supplements, can be useful in the promotion of health and prevention of chronic diseases.
Can pomegranates prevent prostate cancer? A new study offers promise
The juice of the pomegranate, say researchers at University of Wisconsin Medical School, shows major promise to combat prostate cancer-the most common invasive cancer and the second-leading cause of cancer death in American men.
More Pomegranate Juice News Articles
 | Incredible Pomegranate: Plant and Fruit by Richard Ashton The Incredible Pomegranate has been written for fruit-growing enthusiasts, what we like to call a gardeners pomegranate book. All the growing and culture requirements are included. But it is much more than just how to grow pomegranates. There are tales of trips to far-off places in search of pomegranates and people. You will read descriptions of so many different pomegranate varieties, including... |
| Squeezing cold cash out of three "hot" juices.(pomegranate juice, noni juice and mangosteen juice are catching market): An article from: Nutrition Action Healthletter by David Schardt This digital document is an article from Nutrition Action Healthletter, published by Thomson Gale on November 1, 2006. The length of the article is 2482 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.Citation... | |
| The Juice of the Pomegranate by Ethel M. Dell Date not... | |
| Juice of the Pomegranate (New Portway Large Print Books) by Ethel M Dell | |
| The Juice of The Pomegranate by Ethel M. Dell | |
| Pomegranate Juice Uncorked in Major Marketing Success.(POM Wonderful L.L.C.): An article from: Los Angeles Business Journal by Hilary Potkewitz This digital document is an article from Los Angeles Business Journal, published by CBJ, L.P. on May 30, 2005. The length of the article is 1196 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.Citation DetailsTitle:... | |
| Fab 4: juices that serve up a bounty of health benefits: include orange, pomegranate, prune, and unclarified apple juices in your diet to help ward off ... ailments.: An article from: Healthy Years by Gale Reference Team This digital document is an article from Healthy Years, published by Thomson Gale on June 1, 2007. The length of the article is 849 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.Citation DetailsTitle: Fab 4: juices... | |
| The Juice of the Pomegranate by Ethel M Dell | |
| Juice of the Pomegranate by Ethel M. Dell | |
| The Juice of the Pomegranate by Ethel M. Dell |
| © 2008 BrightSurf.com |