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Temperature sensing by the circadian clock
August 17, 2005In the September 1 issue of G&D, Dr. Michael Brunner and colleagues have uncovered the molecular mechanism whereby temperature affects circadian patterns in the fungus Neurospora. The scientists investigated thermosensitive splicing of the central clockwork protein, FREQUENCY (FRQ), into both long (l) and short (s) isoforms depending upon temperature.
They found that at low temperatures, intron 6 of frq mRNA is preferentially spliced, resulting in the exclusion of the l-FRQ translation initiation site.
This mechanism works alongside a temperature-dependent inhibition of translation by uORFs to effectively modulate FRQ levels - and thereby circadian rhythmicity - with changes in ambient temperature.
Dr. Brunner emphasizes that the "interaction of molecular machinery with non-consensus signals-in this case the interaction of splicing machinery with non-consensus splice sites and the interaction of ribosomes with non-consensus translation initiation sites-may provide a general mechanism for temperature-sensing on the molecular level."
Cold Spring Harbor Laboratory
Dr. Brunner emphasizes that the "interaction of molecular machinery with non-consensus signals-in this case the interaction of splicing machinery with non-consensus splice sites and the interaction of ribosomes with non-consensus translation initiation sites-may provide a general mechanism for temperature-sensing on the molecular level."
Cold Spring Harbor Laboratory
Circadian Current Events and Circadian News RSSNew medication brings hope of jet lag cure
A team of researchers from Monash University, The Brigham and Women's Hospital (Boston), Harvard Medical School and Vanda Pharmaceuticals has found a new drug with the potential to alleviate jet lag and sleep disorders caused by shift work.
Plants grow bigger and more vigorously through changes in their internal clocks
Hybrid plants, like corn, grow bigger and better than their parents because many of their genes for photosynthesis and starch metabolism are more active during the day, report researchers from The University of Texas at Austin in a new study published in the journal Nature.
Seasonal Affective Disorder May Be Linked to Genetic Mutation, Study Suggests
With the days shortening toward winter, many people will begin to experience the winter blahs. For some, the effect can be devastating.
Respiratory rhythms can help predict insomnia
The breathing and heart rates and cortisol levels of women with metastatic breast cancer can be used to predict if they'll suffer from chronic insomnia and sleep disruptions, a common complaint from patients who want to maintain their quality of life.
Insomnia in women with breast cancer linked to heart rate dysregulation
A study in the October 15 issue of the Journal of Clinical Sleep Medicine shows that respiratory sinus arrhythmia (RSA) is a significant predictor of insomnia in women with breast cancer and confirmed that longer nocturnal wake episodes were associated with a flatter diurnal cortisol slope.
Brainy genes, not brawn, key to success on mussel beach
It's hard being a mussel: you have to worry about hungry starfish and even hungrier humans, not to mention an environment that can change your body temperature 50 degrees Fahrenheit in just a few hours.
Circadian clock may be critical for remembering what you learn, Stanford researchers say
The circadian rhythm that quietly pulses inside us all, guiding our daily cycle from sleep to wakefulness and back to sleep again, may be doing much more than just that simple metronomic task, according to Stanford researchers.
Researchers Investigate Impact of Stress on Police Officers' Physical and Mental Health
Policing is dangerous work, and the danger lurks not on the streets alone.
The first autism disease genes
The autistic disorder was first described, more than sixty years ago, by Dr. Leo Kanner of the Johns Hopkins Hospital (USA), who created the new label 'early infantile autism'.
Mom's mood, baby's sleep: what's the connection?
If there's one thing that everyone knows about newborn babies, it's that they don't sleep through the night, and neither do their parents.
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