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Temperature sensing by the circadian clock
August 17, 2005In the September 1 issue of G&D, Dr. Michael Brunner and colleagues have uncovered the molecular mechanism whereby temperature affects circadian patterns in the fungus Neurospora. The scientists investigated thermosensitive splicing of the central clockwork protein, FREQUENCY (FRQ), into both long (l) and short (s) isoforms depending upon temperature.
They found that at low temperatures, intron 6 of frq mRNA is preferentially spliced, resulting in the exclusion of the l-FRQ translation initiation site.
This mechanism works alongside a temperature-dependent inhibition of translation by uORFs to effectively modulate FRQ levels - and thereby circadian rhythmicity - with changes in ambient temperature.
Dr. Brunner emphasizes that the "interaction of molecular machinery with non-consensus signals-in this case the interaction of splicing machinery with non-consensus splice sites and the interaction of ribosomes with non-consensus translation initiation sites-may provide a general mechanism for temperature-sensing on the molecular level."
Cold Spring Harbor Laboratory
Dr. Brunner emphasizes that the "interaction of molecular machinery with non-consensus signals-in this case the interaction of splicing machinery with non-consensus splice sites and the interaction of ribosomes with non-consensus translation initiation sites-may provide a general mechanism for temperature-sensing on the molecular level."
Cold Spring Harbor Laboratory
Circadian Current Events and Circadian News RSSNew paper describes connections between Circadian and metabolic systems
A paper by University of Notre Dame biologist Giles Duffield and a team of researchers offers new insights into a gene that plays a key role in modulating the body's Circadian system and may also simultaneously modulate its metabolic system.
Faulty body clock may make kids bipolar
Malfunctioning circadian clock genes may be responsible for bipolar disorder in children. Researchers writing in the open access journal BMC Psychiatry found four versions of the regulatory gene RORB that were associated with pediatric bipolar disorder.
Java and nighttime jobs don't mix: study
Night-shift workers should avoid drinking coffee if they wish to improve their sleep, according to research published in the journal Sleep Medicine.
Hydrogen Peroxide's Link to Living Cells
If a circadian rhythm is like an orchestra - the united expression of the rhythms of millions of cells - a common chemical may serve as the conductor, or at least as the baton.
Circadian surprise: A heat sensor for body-clock synchronization
New research on the fruit-fly brain points to a possible mechanism by which temperature influences the body clock, according to scientists from Queen Mary, University of London.
Texas A&M researchers find new mechanism for circadian rhythm
Molecules that may hold the key to new ways to fight cancer and other diseases have been found to play an important role in regulating circadian rhythm, says Liheng Shi, a researcher in Texas A&M's Department of Veterinary Integrative Biosciences.
The food-energy cellular connection revealed
Our body's activity levels fall and rise to the beat of our internal drums-the 24-hour cycles that govern fundamental physiological functions, from sleeping and feeding patterns to the energy available to our cells.
Scientists reveal new pattern in our daily clock
The findings of a study published in Science today turn a long-held theory on circadian rhythms on its head and mean that we may now be able to develop new drugs and approaches to tune the daily clock to treat sleep disorders and to aid recovery from long-distance flights.
U-M discovery about biological clocks overturns long-held theory
University of Michigan mathematicians and their British colleagues say they have identified the signal that the brain sends to the rest of the body to control biological rhythms, a finding that overturns a long-held theory about our internal clock.
How would Einstein use e-mail?
You're not as different from Albert Einstein and Charles Darwin after all, at least when it comes to patterns of correspondence.
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Natrol Liquid Melatonin - 2-Ounce (Pack of 4) by Natrol Helps Establish Normal Sleep Patterns.* Dietary Supplement. Verified By HPLC MethodNo Yeast, Wheat, Corn, Milk, Egg, Soy, Glutens, Artificial Colors or Flavors, Added Sugar, Starch or Preservatives. * These statements have not been evaluated by theáFood |
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UltraLux Dawn Simulators w/Bulbs by Full Spectrum Solutions Features: Helps to maintain sleep circadian rhythms. Excellent complement to standard light therapy. The UltraLux Simulator wakes you up using the simulation of a natural sunrise (30 minutes). Uses up to a 100watt full spectrum incandescent bulb. Saves up-front cost because you can use your own lamp. Just plug it into your standard wall outlet and then plug in your lamp. Eight hours later, wake to a natural sunrise using brilliant full spectrum light that simulates the sun! For a limited time also receive one free 60 watt Neolite full spectrum bulb and one free 100 watt Neolite full spectrum bulb! Comes with a full one-year warranty on the simulator and 120 days on the bulb. No extra charges! |
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