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Looking at autoimmune diabetes, literally
August 19, 2005METABOLIC DISEASE
A major problem for understanding and treating type1 diabetes is that we are unable to directly, but non-invasively, visualize the inflammatory lesions in the pancreas that cause the disease. In a study appearing online on August 18 in advance of print publication of the September 1 issue of the Journal of Clinical Investigation, Diane Mathis and colleagues from Joslin diabetes Center describe a novel magnetic resonance imaging (MRI) strategy to non-invasively monitor autoimmune inflammation in the pancreas of a living animal.
The researchers were able to track the pancreatic islet infiltrate that accompanies autoimmune diabetes in mice, and follow the resolution of inflammation after successful reversal of diabetes with therapy. This new imaging strategy provides preclinical data on mouse models of Type-1 diabetes that can guide the application of an in vivo MRI technique to patients with autoimmune diabetes.
Journal of Clinical Investigation
Journal of Clinical Investigation
Autoimmune Diabetes Current Events and Autoimmune Diabetes News RSSNew vaccine approach prevents/reverses diabetes in lab study at Children's Hospital of Pittsburgh
Microspheres carrying targeted nucleic acid molecules fabricated in the laboratory have been shown to prevent and even reverse new-onset cases of type 1 diabetes in animal models. The results of these studies were reported by diabetes researchers at the John G. Rangos Sr. Research Center at Children's Hospital of Pittsburgh of UPMC and Baxter Healthcare Corporation.
Suspected cause of type 1 diabetes caught
Scientists at Washington University School of Medicine in St. Louis working with diabetic mice have examined in unprecedented detail the immune cells long thought to be responsible for type 1 diabetes.
MGH initiates phase I diabetes trial
Scientists at the Massachusetts General Hospital (MGH) have initiated a phase 1 clinical trial to reverse type 1 diabetes.
UVa Health System Team Uncovers Gene's Role in Type 1 Diabetes
Researchers at the University of Virginia Health System have identified an enzyme thought to be an important instigator of the inner-body conflict that causes Type 1 diabetes.
Scientists Implicate Gene in Vitiligo and Other Autoimmune Diseases
In a study appearing in the March 22 New England Journal of Medicine, scientists supported by the National Institutes of Health's National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) have discovered a connection between a specific gene and the inflammatory skin condition vitiligo, as well as a possible host of autoimmune diseases.
LIAI scientists make major finding on potential cure for type 1 diabetes
A major finding, which represents an important step toward a potential cure for type 1 (insulin-dependent) diabetes, has been made by a research team at the La Jolla Institute for Allergy & Immunology (LIAI).
Scientists directly view immune cells interacting to avert autoimmunity
Using a new form of microscopy to penetrate living lymph nodes, UCSF scientists have for the first time viewed immune cells at work, helping clarify how T cells control autoimmunity.
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