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Thyroid hormone, brain development, and behavior
August 30, 2005Dr. Bjorn Vennstrom and colleagues in Spain and at the Karolinska Institute (Sweden) have identified novel neural functions of thyroid hormone (TH), revealing that it is required during discrete periods of brain development to confer "normal" behavior.
The scientists used transgenic mice heterozygous for a mutant form of the thyroid hormone receptor alpha1 that has about a ten-fold reduced affinity for its natural ligand, TH. They observed that reduced TH signaling during development lead to distinct neurological abnormalities in adulthood: extreme anxiety, reduced memory and locomotor dysfunction. Interestingly, the anxiety and memory impairment could be suppressed through dietary supplementation of the adult mice with TH (supplementation was not effective when administered as a juvenile).
Conversely, the uncoordination could be normalized through TH injections at juvenile (but not adult) stages. "Since most psychiatric diseases are thought to have a polygenic background, these discoveries may have valuable implications for the diagnosis and treatment of certain mood disorders," explains Dr. Vennstrom.
Cold Spring Harbor Laboratory
Cold Spring Harbor Laboratory
Thyroid Hormone News and Current Thyroid Hormone Events RSSThyrotropin levels associated with Alzheimer's disease risk in women
Women with low or high levels of the hormone thyrotropin, which affects thyroid gland function and thyroid hormone levels, appear to have a higher risk of developing Alzheimer's disease, according to a report in the July 28 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.
Newly discovered role of thyroid hormone during pregnancy
Thyroid hormone deficiencies in early pregnancy can cause locomotor underdevelopment in the child, according to research from the Swedish medical university Karolinska Institutet. The results bring new insights into brain development and could affect routine pregnancy testing.
Thyroid treatment no 'quick fix' for weight loss in children
Children treated for hypothyroidism aren't likely to drop pounds with treatment for the condition says a new study in the Journal of Pediatrics. The study is the first to examine the link between hypothyroidism treatment and weight loss in pediatric patients.
New strategy to cut heart attack risk is effective in initial test
The first clinical trial of a new kind of drug to cut the risk of cardiovascular disease has been found safe and effective at dropping levels of "bad" low density lipoprotein (LDL) cholesterol by as much as 40 percent.
Dartmouth researchers show effects of low dose arsenic on development
A team of Dartmouth Medical School (DMS) researchers has determined that low doses of arsenic disrupt the activity of a hormone critical in development.
Researchers reveal repressor protein blocks neural stem cell development
A protein known to repress gene transcription at the molecular level in a variety of processes also blocks embryonic neural stem cells from differentiating into neurons.
Ethanol injection helps manage bone metastasis in thyroid cancer patients
Percutaneous ethanol injection (PEI)-an injection of ethanol (alcohol) through the skin directly into a bone tumor to kill cancer cells-may be a valuable ancillary treatment for thyroid cancer patients whose cancer has spread to the bone. Japanese researchers announced these findings during the 54th Annual Meeting of SNM, the world's largest society for molecular imaging and nuclear medicine.
Obesity And Environmental Chemicals: Research Probes Potential Link
A team of researchers at UNH is investigating whether the increasing ubiquity of chemical flame retardants found in foam furniture, carpeting, microwaves and computers might be related to the climbing rate of obesity in the United States.
UI Study Reveals Value of Schizophrenia-Related Gene Variation
University of Iowa researchers have learned more about a genetic variation that is a small risk factor for a mild form of schizophrenia, yet also is associated with improved overall survival.
How appetite-stimulating brain cells work overtime during fasting
During periods of fasting, brain cells responsible for stimulating the appetite make sure that you stay hungry. Now, a new study of mice reported in the January issue of the journal Cell Metabolism, published by Cell Press, reveals the complex series of molecular events that keep those neurons active.
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