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New study suggests mechanism of action for botox in the treatment of enlarged prostate
September 01, 2005Botox appears to alter specific cellular processes that contribute to prostate enlargement according to new study results presented by researchers from the University of Pittsburgh and Chang Gung Memorial Hospital in Taiwan at the International Continence Society annual meeting in Montreal.
"Most men consider an enlarged prostate and the irritating symptoms that accompany it as an inevitability of aging and may not seek help because currently available therapies can have serious side effects, including impotence," said Michael Chancellor, M.D., professor of urology at the University of Pittsburgh School of Medicine. "Alternative treatments are needed and we've taken an important step by demonstrating how Botox can work as a potential new therapy for the large number of men who suffer from this condition."
The research team had previously demonstrated that injection of Botox (botulinum toxin A) into the prostrate gland produced improvement in symptoms such as the frequent urge to urinate, incomplete emptying of the bladder and low urine flow rate in men with bladder outlet obstruction due to BPH. The current study was conducted to investigate the mechanism of action by which Botox might work to reduce these symptoms.
For this study, researchers injected varying doses of Botox into the enlarged prostates of adult male rats. One week after injection, two types of altered cellular dynamics were observed, including an increase in apoptosis (cell death) and inhibition of cell proliferation, and down-regulation of adrenergic receptors in the prostate. Adrenergic receptors cause the contraction of the prostate and bladder muscles, making it difficult to void urine. By blocking these receptors, the muscles relax, allowing urine to flow more freely.
BPH is a non-cancerous growth of the prostate that can interfere with urination. It is one of the most common diseases affecting men, with current studies indicating that more than half of all men over the age of 60, and 80 percent of all men by age 80, will have enlarged prostates. Forty to 50 percent of the men who develop enlarged prostates will present with symptoms which include more frequent urination, urinary tract infections, the inability to completely empty the bladder, and, in severe cases, damage to the bladder and kidneys.
University of Pittsburgh Medical Center
For this study, researchers injected varying doses of Botox into the enlarged prostates of adult male rats. One week after injection, two types of altered cellular dynamics were observed, including an increase in apoptosis (cell death) and inhibition of cell proliferation, and down-regulation of adrenergic receptors in the prostate. Adrenergic receptors cause the contraction of the prostate and bladder muscles, making it difficult to void urine. By blocking these receptors, the muscles relax, allowing urine to flow more freely.
BPH is a non-cancerous growth of the prostate that can interfere with urination. It is one of the most common diseases affecting men, with current studies indicating that more than half of all men over the age of 60, and 80 percent of all men by age 80, will have enlarged prostates. Forty to 50 percent of the men who develop enlarged prostates will present with symptoms which include more frequent urination, urinary tract infections, the inability to completely empty the bladder, and, in severe cases, damage to the bladder and kidneys.
University of Pittsburgh Medical Center
Botox Current Events and Botox News RSSNew technique for injectable facial fillers improves comfort, recovery
Less pain during injections for wrinkle-fighting facial fillers. Less swelling afterward. Less time in the office waiting for anesthesia to take effect.
Baby boomers' boon? LED light and green tea cream to smooth facial wrinkles
Scientists in Germany are reporting a major improvement in their potential new treatment for facial wrinkles that could emerge as an alternative to Botox and cosmetic surgery.
Dysport proves safe, effective anti-wrinkle treatment, UT Southwestern plastic surgeons find
The new anti-wrinkle facial filler Dysport, which could be used as an alternative to Botox, noticeably reduced frown lines between the eyes, according to users and independent reviewers in a study involving plastic surgeons at UT Southwestern Medical Center.
Got migraines?
Migraine headaches are a drain - not only on the estimated 30 million Americans who suffer from them, but on the economy, too.
Recession cuts many, not all plastic surgery procedures
Showing sensitivity to weaknesses in the U.S. economy, plastic surgery was not spared from the recession's grasp. According to the newest national procedural statistics report from the American Society of Plastic Surgeons (ASPS), in 2008, doctors performed over 12 million cosmetic plastic surgery procedures - encompassing both surgical and minimally-invasive procedures.
'Smile doctors' create, restore and enhance patients' smiles
Imagine not having the ability to return the smile of a loved one or being too embarrassed by your mouth's appearance to display a smile.
Millennials' medspa influence
The American Academy of Cosmetic Surgery has released its results from a consumer survey asking 1,000 women their opinions on medical spas.
American Pain Society's low back guideline expanded to cover interventional procedures
For low-back pain patients and their doctors, the American Pain Society, www.ampainsoc.org, said today it is expanding its evidence-based, clinical practice guideline on diagnosis and treatment of chronic low back pain to include recommendations on surgery and other interventional treatments.
Botox for newborns
Botulinum toxin, also called Botox, is best known as one of the most commonly used molecules to reduce wrinkles. It is also known as one of the most poisonous naturally occurring substances.
Men are opting to remove spider veins over replacing hair
The American Academy of Cosmetic Surgery (AACS) is pleased to announce the results of its 2007 Procedural Data. This information is collected by polling the Academy's U.S.-based members.
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