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Human muscle-derived stem cells effective in animal models of incontinence
September 01, 2005First human trials have started in Canada
MONTREAL - Human muscle-derived cells, pluripotent stem cells found in muscle, have been used to cure stress urinary incontinence in animal models, a finding which signals that these cells are prime candidates to treat the condition in adults. The research will be presented by University of Pittsburgh researchers at the annual meeting of the International Continence Society Aug. 29 through Sept. 2 in Montreal.
In the study, the Pittsburgh researchers led by Michael Chancellor, M.D., injected the human muscle-derived stem cells into the periurethral muscle of a well-established animal model for stress urinary incontinence. After four weeks, the models' leak-point pressure, the pressure at which urine would leak from the bladder, had been restored to levels that would be seen normally.
"In past studies we have shown that muscle-derived cells from rats have been able to restore deficient muscle in the bladder. Using human muscle-derived cells was the next step in bringing this therapy to humans," said Dr. Chancellor, who is professor of urology at the University of Pittsburgh School of Medicine.
Researchers believe that the human muscle-derived cells were able to restore leak-point pressure to normal levels by differentiating into new muscle fibers, which prevented periurethral muscle atrophy. They will be returning to the lab to identify exactly how these cells work to regenerate muscle.
Clinical trials using muscle-derived cell therapy for incontinence have recently begun in Toronto.
Urinary incontinence affects 13 million Americans. Those with stress urinary incontinence involuntarily lose urine while doing activities that put stress on the abdomen, such as laughing, sneezing, coughing, lifting or walking. A result of damage to the urethral sphincter, stress incontinence is most often caused by childbirth, menopause or pelvic surgery.
University of Pittsburgh Medical Center
"In past studies we have shown that muscle-derived cells from rats have been able to restore deficient muscle in the bladder. Using human muscle-derived cells was the next step in bringing this therapy to humans," said Dr. Chancellor, who is professor of urology at the University of Pittsburgh School of Medicine.
Researchers believe that the human muscle-derived cells were able to restore leak-point pressure to normal levels by differentiating into new muscle fibers, which prevented periurethral muscle atrophy. They will be returning to the lab to identify exactly how these cells work to regenerate muscle.
Clinical trials using muscle-derived cell therapy for incontinence have recently begun in Toronto.
Urinary incontinence affects 13 million Americans. Those with stress urinary incontinence involuntarily lose urine while doing activities that put stress on the abdomen, such as laughing, sneezing, coughing, lifting or walking. A result of damage to the urethral sphincter, stress incontinence is most often caused by childbirth, menopause or pelvic surgery.
University of Pittsburgh Medical Center
Stem Cells Current Events and Stem Cells News RSSNew discovery about the formation of new brain cells
The generation of new nerve cells in the brain is regulated by a peptide known as C3a, which directly affects the stem cells' maturation into nerve cells and is also important for the migration of new nerve cells through the brain tissue, reveals new research from the Sahlgrenska Academy published in the journal Stem Cells.
Umbilical cord blood stem cell transplant may help lung, heart disorders
Two separate studies published in the current issue of Cell Transplantation (18:8), - now freely available on-line have shown that transplanted human-derived umbilical cord blood (UCB) stem cells transplanted in an animal model had positive therapeutic effects on specific lung and heart disorders the animal models.
Gene mismatch influences success of bone marrow transplants
A commonly inherited gene deletion can increase the likelihood of immune complications following bone marrow transplantation, an international team of researchers reports in the November 22 advance online issue of Nature Genetics.
New research shows versatility of amniotic fluid stem cells
For the first time, scientists have demonstrated that stem cells found in amniotic fluid meet an important test of potential to become specialized cell types, which suggests they may be useful for treating a wider array of diseases and conditions than scientists originally thought.
First reconstitution of an epidermis from human embryonic stem cells
Stem cell research is making great strides. This is yet again illustrated by a study carried out by the I-STEM* Institute (I-STEM/ Inserm UEVE U861/AFM), published in the Lancet on 21 November 2009. The I-STEM team, directed by Marc Peschanski has just succeeded in recreating a whole epidermis from human embryonic stem cells.
Bone Implant Offers Hope for Skull Deformities
A synthetic bone matrix offers hope for babies born with craniosynostosis, a condition that causes the plates in the skull to fuse too soon.
Your Own Stem Cells Can Treat Heart Disease
The largest national stem cell study for heart disease showed the first evidence that transplanting a potent form of adult stem cells into the heart muscle of subjects with severe angina results in less pain and an improved ability to walk. The transplant subjects also experienced fewer deaths than those who didn't receive stem cells.
Is hepatic differentiation of embryonic stem cells induced by valproic acid and cytokines?
Embryonic stem (ES) cells, known for their capacity to proliferate indefinitely and differentiate into almost all types of cells including hepatocytes, have raised the hope of cellular replacement therapy for liver failure.
Paradoxical protein might prevent cancer
One difficulty with fighting cancer cells is that they are similar in many respects to the body's stem cells. By focusing on the differences, researchers at Karolinska Institutet have found a new way of tackling colon cancer. The study is presented in the prestigious journal Cell.
U of M researchers find 2 units of umbilical cord blood reduce risk of leukemia recurrence
A new study from the Masonic Cancer Center, University of Minnesota shows that patients who have acute leukemia and are transplanted with two units of umbilical cord blood (UCB) have significantly reduced risk of the disease returning.
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