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UVa Participates in Landmark Breast Cancer Screening Trial
September 21, 2005CHARLOTTESVILLE, Va. - Digital mammography that uses computers to detect breast cancer found significantly (up to 28%) more cancers than screen film mammography in women 50 and younger, premenopausal and perimenopausal women, and women with dense breasts, according to results from one of the largest breast cancer screening studies ever performed.
However, the study showed no difference between digital and standard x-ray mammography in detecting breast cancer for the general population of women. More than 1,300 women took part in the trial at the University of Virginia Health System, one of 33 sites in the U.S. and Canada to study the effectiveness of digital mammogram technology.
"It's important for every women to get a quality mammogram. But if you're under 50, premenopausal or know you have dense breast tissue, you should consider having a digital mammogram at your next scheduled screening," said Dr. Jennifer Harvey, a radiologist and head of breast imaging at the UVa Health System and site investigator for the trial at UVa. "However, women should not delay getting a mammogram if only film screen technology is available. Traditional film screen mammograms save lives as well."
Digital mammography takes an electronic image of the breast and stores it directly in a computer, allowing the recorded data to be enhanced, magnified, or manipulated for further evaluation. The electronic image also can be printed on film. Film mammography units use film to both capture and display the image. The sensitivity of film mammography is somewhat limited in women with dense breasts, a population at higher risk for breast cancer.
UVa has been performing digital mammography as part of research studies since the mid-1990's and for clinical use since 2001. The breast program at UVa currently has three GE digital mammogram machines for patients, two in the Breast Care Center in the West Complex and one at Northridge. A fourth digital machine is expected in mid-October to be housed in UVa's mobile mammography van.
According to the National Cancer Institute, breast cancer is the most common non-skin cancer, and the second leading cause of cancer-related death in women in the United States. An estimated 211,240 women will be diagnosed with breast cancer and an estimated 40,410 women will die of the disease in the U.S. in 2005.
The results of the trial, called DMIST (Digital Mammographic Imaging Screening Trial), are reported in a special online publication of the New England Journal of Medicine. The trial was funded by the NCI and conducted by the American College of Radiology Imaging Network (ACRIN).
Starting in October 2001, DMIST enrolled nearly 50,000 women who had no signs of breast cancer. Women in the trial were given both digital and film mammograms. Mammograms were interpreted independently by two different radiologists. Breast cancer status of the participants was determined through breast biopsy or follow-up mammography.
"I am very proud of the accomplishments of the DMIST researchers," said Dr. Bruce Hillman, a professor of radiology at the UVa Health System and chair of ACRIN.
"This landmark trial, along with others currently being conducted by ACRIN, will influence the appropriate care for women everywhere."
University of Virginia
Digital mammography takes an electronic image of the breast and stores it directly in a computer, allowing the recorded data to be enhanced, magnified, or manipulated for further evaluation. The electronic image also can be printed on film. Film mammography units use film to both capture and display the image. The sensitivity of film mammography is somewhat limited in women with dense breasts, a population at higher risk for breast cancer.
UVa has been performing digital mammography as part of research studies since the mid-1990's and for clinical use since 2001. The breast program at UVa currently has three GE digital mammogram machines for patients, two in the Breast Care Center in the West Complex and one at Northridge. A fourth digital machine is expected in mid-October to be housed in UVa's mobile mammography van.
According to the National Cancer Institute, breast cancer is the most common non-skin cancer, and the second leading cause of cancer-related death in women in the United States. An estimated 211,240 women will be diagnosed with breast cancer and an estimated 40,410 women will die of the disease in the U.S. in 2005.
The results of the trial, called DMIST (Digital Mammographic Imaging Screening Trial), are reported in a special online publication of the New England Journal of Medicine. The trial was funded by the NCI and conducted by the American College of Radiology Imaging Network (ACRIN).
Starting in October 2001, DMIST enrolled nearly 50,000 women who had no signs of breast cancer. Women in the trial were given both digital and film mammograms. Mammograms were interpreted independently by two different radiologists. Breast cancer status of the participants was determined through breast biopsy or follow-up mammography.
"I am very proud of the accomplishments of the DMIST researchers," said Dr. Bruce Hillman, a professor of radiology at the UVa Health System and chair of ACRIN.
"This landmark trial, along with others currently being conducted by ACRIN, will influence the appropriate care for women everywhere."
University of Virginia
Breast Cancer Screening Current Events and Breast Cancer Screening News RSSStudy finds delay in follow-up among African-American women receiving abnormal breast finding
A new analysis has identified a significant delay in follow-up times among African-American women after the finding of a suspicious breast abnormality.
African-American women still have poorer breast cancer outcomes
New research published in the May issue of the Journal of the American College of Surgeons shows that dramatic disparities in breast cancer outcomes continue to exist for African-American women, regardless of the age at which they are diagnosed, extent of the cancer, type of treatment or socioeconomic status.
Obese women play cancer roulette
Obese women may be putting themselves at greater risk of breast cancer by not undergoing regular screening. According to new research by Dr. Nisa Maruthur and her team from The John Hopkins University School of Medicine in Baltimore, USA, seriously obese women are significantly less likely to say they have undergone a recent mammography than normal weight women, especially if they are white.
Study identifies double-balloon enteroscopy as cost-effective approach for obscure GI bleeding
A cost-effectiveness analysis conducted by researchers at Stanford University Hospital in Calif., shows that an initial double-balloon enteroscopy (DBE) is a cost-effective approach for patients with obscure gastrointestinal (GI) bleeding.
Fear, misconceptions about screenings keep many African-Americans from getting mammograms
Training physicians and caregivers to improve cultural sensitivity and communication with economically disadvantaged African-American patients could influence these women to get mammograms that could save their lives.
MRI spots DCIS in mice
A new magnetic resonance imaging procedure can detect very early breast cancer in mice, including ductal carcinoma in situ (DCIS), a precursor to invasive cancer. Some of the tumors detected were less than 300 microns in diameter, the smallest cancers ever detected by MRI.
Risk of death after cancer diagnosis; shift in stage of breast cancer diagnosis
Cancer patients with low socioeconomic status (SES) have more advanced cancers at diagnosis, receive less aggressive treatment, and have a higher risk of dying in the five years following cancer diagnosis, according to a new study.
Kylie's breast cancer triggered a surge of over 30 percent in breast imaging of low-risk women
Use of mammography and breast ultrasound procedures soared by over 30 percent among women aged 25-44 in the 6 months following Kylie Minogue's breast cancer diagnosis, says a new study from the University of Melbourne.
Adding ultrasound screening to mammography brings benefits, risks
Adding a screening ultrasound examination to routine mammography reveals more breast cancers than mammography alone, according to results of a major new clinical trial. The trial, however, also found that adding an ultrasound exam also increases the rate of false positive findings and unnecessary biopsies.
Mammography may be beneficial to all women, regardless of age
According to researchers at The University of Texas M. D. Anderson Cancer Center, mammography, the gold-standard for breast cancer screening and early detection, has shown to significantly reduce the risk of being diagnosed with advanced stage breast cancer in women over the age of 80, an age group currently without clear guidelines recommending regular screenings.
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