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Scientists develop screening method for pancreatic cancer
September 21, 2005Scientists at the University of Liverpool have found a way of identifying families at high risk of pancreatic cancer.
The team has developed a novel means of testing for pancreatic cancer that will enable doctors to treat the killer disease at its earliest stages. They are also now able to show how the risk of cancer for these patients changes with age.
The Liverpool-based study group known as EUROPAC (European Registry Of Hereditary Pancreatitis And Familial Pancreatic Cancer), working in collaboration with a similar group in Germany, has shown that familial pancreatic cancer develops at an increasingly younger age as it is passed down generations-a phenomenon known as anticipation.
In the largest study of its kind, the team surveyed 600 families with a history of pancreatic cancer and identified a subgroup of over 80 families whose lifetime risk of developing the cancer was 50 per cent.
Dr Bill Greenhalf, from the University's Division of Surgery and Oncology, said: "Of those families with the highest incidence of pancreatic cancer, we found that members developed the disease at a younger age in each generation. As well as giving important clues about the nature of the disease, this allows a more accurate estimate of the risk an individual faces of developing cancer in the short term so we can treat the cancer as soon as possible."
The team led by Dr Greenhalf has developed a novel method of analysing pancreatic juice, taken from patients in families with a history of pancreatic cancer. By analysing DNA scientists are able to identify specific genetic mutations that indicate the chances of a patient developing the disease in the short term, ranging from a 0.1% chance to a 90% certainty.
Dr Greenhalf added: "Our research has provided strong evidence that anticipation and pancreatic juice analysis are the most effective means of screening for pancreatic cancer in families with a history of the disease. We intend to carry out further trials of these techniques and hope the results encourage more widespread adoption of these screening methods."
University of Liverpool
In the largest study of its kind, the team surveyed 600 families with a history of pancreatic cancer and identified a subgroup of over 80 families whose lifetime risk of developing the cancer was 50 per cent.
Dr Bill Greenhalf, from the University's Division of Surgery and Oncology, said: "Of those families with the highest incidence of pancreatic cancer, we found that members developed the disease at a younger age in each generation. As well as giving important clues about the nature of the disease, this allows a more accurate estimate of the risk an individual faces of developing cancer in the short term so we can treat the cancer as soon as possible."
The team led by Dr Greenhalf has developed a novel method of analysing pancreatic juice, taken from patients in families with a history of pancreatic cancer. By analysing DNA scientists are able to identify specific genetic mutations that indicate the chances of a patient developing the disease in the short term, ranging from a 0.1% chance to a 90% certainty.
Dr Greenhalf added: "Our research has provided strong evidence that anticipation and pancreatic juice analysis are the most effective means of screening for pancreatic cancer in families with a history of the disease. We intend to carry out further trials of these techniques and hope the results encourage more widespread adoption of these screening methods."
University of Liverpool
Pancreatic Cancer Current Events and Pancreatic Cancer News RSSRare pancreatic cancer patients may live longer when treated with radiation therapy
Radiation therapy is effective in achieving local control and palliation in patients with pancreatic neuroendocrine tumors (PNTs), despite such tumors being commonly considered resistant to radiation therapy.
African-Americans with colorectal cancer have poorer outcomes, lower survival rates
New research published in the November issue of the Journal of the American College of Surgeons shows that African-American patients with colorectal cancer are more likely to be diagnosed with advanced disease and are less likely to undergo surgical procedures compared with Caucasians, suggesting that improvements in screening and rates of operation may reduce differences in colorectal cancer outcomes for African-Americans.
Discovery offers potential new pancreatic cancer treatment
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M. D. Anderson examines use of toad venom in cancer treatment
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Pancreatic cancer: Researchers find drug that reverses resistance to chemotherapy
For the first time researchers have shown that by inhibiting the action of an enzyme called TAK-1, it is possible to make pancreatic cancer cells sensitive to chemotherapy, opening the way for the development of a new drug to treat the disease.
Endothelin-1 inhibitors in chronic pancreatitis
Fibrosis is a key feature of chronic pancreatitis and pancreatic cancer. The extensive deposition of extracellular matrix proteins fosters the development of an exocrine and endocrine organ insufficiency, and accelerates progression of the tumour.
Autoimmune response can induce pancreatic tumor rejection
Immune responses are capable of killing tumors before they can be directed toward normal body tissue, according to new scientific findings published in Cancer Research, a journal of the American Association for Cancer Research.
MicroRNAs circulating in blood show promise as biomarkers to detect pancreatic cancer
A blood test for small molecules abnormally expressed in pancreatic cancer may be a promising route to early detection of the disease.
Blood-flow metabolism mismatch predicts pancreatic tumor aggressiveness
Researchers from Turku, Finland, have identified a blood-flow glucose consumption mismatch that predicted pancreatic tumor aggressiveness, according to results of a study published in Clinical Cancer Research, a journal of the American Association for Cancer Research.
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