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A cytokine not kind to an injury of the spine
September 23, 2005Transverse Myelitis (TM) is an autoimmune inflammatory disease of the central nervous system that is characterized by focal spinal cord demyelination and axonal injury. TM causes paralysis and other neurologic disabilities, but has limited treatment options due to a lack of understanding of its underlying mechanisms.
In a paper appearing online on September 22 in advance of print publication of the October 1 issue of the Journal of Clinical Investigation, Douglas Kerr and colleagues from Johns Hopkins find that levels of the cytokine IL-6 are selectively increased in cerebrospinal fluid from TM patients. The researchers show that elevated IL-6 levels alone are necessary and sufficient to mediate injury to both neuronal and glial cells, in a manner that is dependent on nitric oxide.
This is the first description of IL-6 as a mediator of neural injury. Further, high levels of IL-6 were directly correlated with tissue injury and clinical disability, suggesting that IL-6 may be an important biomarker of TM. This new data may aid in the development of effective therapies against TM and other inflammatory diseases of the central nervous system.
Journal of Clinical Investigation
Journal of Clinical Investigation
Cytokine Current Events and Cytokine News RSSNew culprit for viral infections among elderly -- an overactive immune response
Researchers at Yale School of Medicine have found that exaggerated responses of the immune system explain why the elderly succumb to viral infections more readily than younger people.
Largest gene study of childhood IBD identifies 5 new genes
In the largest, most comprehensive genetic analysis of childhood-onset inflammatory bowel disease (IBD), an international research team has identified five new gene regions, including one involved in a biological pathway that helps drive the painful inflammation of the digestive tract that characterizes the disease.
Manipulating Brain Inflammation May Help Clear Brain of Amyloid Plaques, Mayo Clinic Researchers Say
In a surprising reversal of long-standing scientific belief, researchers at the Mayo Clinic campus in Florida have discovered that inflammation in the brain is not the trigger that leads to buildup of amyloid deposits and development of Alzheimer's disease.
New chromosomal abnormality identified in leukemia associated with Down syndrome
Researchers identified a new chromosomal abnormality in acute lymphoblastic leukemia (ALL) that appears to work in concert with another mutation to give rise to cancer. This latest anomaly is particularly common in children with Down syndrome.
Oxidized form of a common vitamin may bring relief for ulcerative colitis
New research published in the Journal of Leukocyte Biology finds retinoic acid may alleviate ulcerative colitis and similar irritable bowel diseases.
Pancreatic cancer: Researchers find drug that reverses resistance to chemotherapy
For the first time researchers have shown that by inhibiting the action of an enzyme called TAK-1, it is possible to make pancreatic cancer cells sensitive to chemotherapy, opening the way for the development of a new drug to treat the disease.
Pitt study finds molecular link between insulin resistance and inflammation
An exploration of the molecular links between insulin resistance and inflammation may have revealed a novel target for diabetes treatment, say scientists at the John G. Rangos Sr. Research Center, Children's Hospital of Pittsburgh of UPMC.
Case Western Reserve researchers discover the key to malaria susceptibility in children
A team of researchers from Case Western Reserve University School of Medicine have solved the mystery of why some children are more susceptible to malaria infection and anemia.
Discovery to aid in future treatments of third-world parasites
Schistosomiasis, one of the most important of the neglected tropical diseases, is caused by infection with parasitic helminths of the genus Schistosoma.
Study identifies biomarker that safely monitors tumor response to new brain cancer treatment
A specific biomarker, a protein released by dying tumor cells, has been identified as an effective tool in an animal model to gauge the response to a novel gene therapy treatment for glioblastoma mulitforme.
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The Cytokine Handbook, Two-Volume Set, Volume 1-2, Fourth Edition by Angus W. Thomson (Editor), Michael T. Lotze (Editor) The fourth edition of The Cytokine Handbook provides an encyclopedic coverage of the molecules that induce and regulate immune responses. Now expanded to two volumes, co-edited by Michael T Lotze, and written by over 120 international experts, the scope of the book has been broadened to include a major emphasis on the clinical applications of cytokines. The early chapters discuss individual cytokines, chemokines and receptors. Additional chapters discuss the clinical implications and applications of cytokines, including cytokine gene transfer, antisense therapy and assay systems. This book is essential for researchers and clinicians interested in cytokines, including anyone working in cancer biology, transplantation, infectious diseases, autoimmunity or bioinformatics. ... |
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Cytokines in Pulmonary Disease: Infection and Inflammation (Lung Biology in Health and Disease) by Steve Nelson (Author), Thomas R. Martin (Author) Louisiana State Univ. Medical Ctr., New Orleans. Reviews recent research and clinical trials on the behavior of inflammatory mediators in the pathogenesis and resolution of pathogen-specific pulmonary infections. For specialists, medical students, and graduate students in microbiology, and cell and molecular biology. |
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Source Naturals AHCC Active Hexose Correlated Compound 750mg, 60 capsules by Source Naturals Dietary supplement. Active hexose correlated compound. Increases natural killer cell activity. AHCC (Active Hexose Correlated Compound) is a proprietary compound produced by cultivation and enzymatic modification of several species of mushroom mycelia, including shiitake, grown in rice bran extract. Considered a superfood supplement in Japan, AHCC has been researched extensively for its immune enhancement properties. According to human and animal research, AHCC may significantly increase Natural Killer (NK) cell activity. AHCC may also increase macrophage activity, enhance cytokine production, and support the healthy functioning of the liver as well as act as an antioxidant. (These statements have not been evaluated by the Food and Drug Administration. This product is not intended to... |
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ReLuma Skin Illuminating Anti Aging Serum with Cytokines by Dr Nathan Newman A pharmaceutical grade product formulated with multiple human growth factors and matrix proteins that repair damaged skin and minimize further sizes of aging, restoring the skin's natural luminosity and health. |
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Xenobiotics and Inflammation: Roles of Cytokines and Growth Factors by Schook (Author), Lashkin (Author) The affect of xenobiotics on host resistance in general and specific immune functions has become the focus of much current research. This book synthesises current information on how chemicals (xenobiotics) can affect the immune system to cuse dysfunction, focusing on the process of inflammation. It provides a much needed, single-source reference for researchers investigation the mechanisms responsible for altered host resistance following exposture to xenobiotics. Emphasis is placed on the roles of cytokines and growth factors in the inflammatory process and how such processes are altered and modulated by xenobiotics. This volume contains information pertinent to those exploring cell growth, angiogenesis, hematopoetic differentiation, and recruitment to and proliferation of cells in... | |
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Clinical Applications of Cytokines: Role in Pathogenesis, Diagnosis, and Therapy by Joost J. Oppenheim (Editor), Jeffrey L. Rossio (Editor), Andrew J.H. Gearing (Editor) The driving force for research on cytokines has always been their clinical promise. Their biological properties suggested a key role in hematopoiesis, immunity, tumor genesis, hemostasis, vascularization, repair of connective tissues and integration of the immune system with the neuroendocrine system. Animal studies have shown that cytokines could be used as effective biotherapeutics with easily manageable and reversible toxicities. Clinical trials have confirmed these findings, culminating in the licensing of a number of the cytokines such as interferon alpha, interferon gamma, interleukin 2, erythropoietin, granulocyte colony stimulating factor, and granulocyte-macrophage colony stimulating factor. Many other cytokines are in clinical trials. This is the first comprehensive volume... | |
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Cytokines, Stress, and Depression (Advances in Experimental Medicine and Biology) by Robert Dantzer (Author), Raz Yirmiya (Author), Emmanuelle E. Wollmann (Author) Until a few years ago, cytokines were only known to immunologists; now these molecules have burst upon neurosciences and permeated several avenues of current research. This book examines the possible role of cytokines in mental depression, based on recent clinical and experimental data, and constitutes the first attempt to make a synthesis between the exciting new developments in cytokine research and their implications for the pathophysiology of mental disorders. |
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RE LUMA Skin Illuminating Anti-Aging Serum with Cytokines 1oz (PRO SIZE) by INVITRIX A pharmaceutical grade product formulated with multiple human growth factors and matrix proteins that repair damaged skin and minimize further sizes of aging, restoring the skin's natural luminosity and health. |
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Cytokines: Stress and Immunity, Second Edition by Nicholas P. Plotnikoff (Editor), Robert E. Faith (Editor), Anthony J. Murgo (Editor), Robert A. Good (Editor) Cytokine involvement in the immune system's response to stress is now very well documented. Cytokine activity has been implicated in a variety of mental and physical diseases, and has been shown to have a significant role in fueling the vicious circle of depression and illness. The first edition of Cytokines: Stress and Immunity pointed out that the immune system does not stand alone, but is profoundly affected by other organ systems, especially the central nervous and the neuroendocrine systems, with cytokines being the common tool of communication. This edition continues on the trailblazing path of the original to once again present current research that informs our evolving understanding of how cytokines function and the clinical implications of cytokine... |
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Source Naturals AHCC, 500 mg, Capsules, 60 capsules by Source Naturals Dietary supplement. Increases natural killer cell activity. Active hexose correlated compound. AHCC (active hexose correlated compound) is a proprietary compound produced by cultivation and enzymatic modification of several species of mushroom mycelia, including shiitake, grown in rice bran extract. Considered a superfood supplement in Japan, AHCC has been researched extensively for its immune enhancement properties. According to human and animal research, AHCC may significantly increase natural killer (NK) cell activity. AHCC may also increase macrophage activity, enhance cytokine production, and support the healthy functioning of the liver as well as act as an antioxidant. (These statements have not been evaluated by the Food and Drug Administration. This product is not intended to... |
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