 |
|
Neural development protein disproved as marker for schizophrenia
October 24, 2005The protein Oct-6 is not a biological marker for schizophrenia. The results of a study published today in the open access journal BMC Psychiatry contradict previous findings and show that Oct-6, a protein involved in neurodevelopment, is normally expressed in the adult brain and cannot be used to identify patients with schizophrenia.
Oct-6 was shown to be expressed in the brain of patients diagnosed with schizophrenia, but not in the brain of healthy individuals, in a study led by Jack Price and published in the July 2002 issue of The American Journal of Psychiatry. Kirenjeet Ubhi and Jack Price, from Kings College London, UK have now replicated Price's original study and extended it. Their findings contradict Price's earlier study.
Events affecting brain development are thought to underlie the occurrence of schizophrenia in later life. Oct-6 plays a crucial role in neurodevelopment, and a genetic variation within the Oct-6 gene has been linked to a subset of patients with schizophrenia and bipolar disorder; therefore, Oct-6 seemed like a good candidate for a biological marker for these disorders.
Ubhi and Price extended Price's original study to include patients with bipolar disorder and major depression - it has been suggested that schizophrenia shares a common pathology with these disorders. They analysed post-mortem brain samples from 3 groups of 15 patients. The first group had been diagnosed with schizophrenia, the second group with bipolar disorder and the third group with major depressive disorder. They used 15 brain samples of matched healthy individuals as controls. Oct-6 mRNA and protein expression were determined by in-situ hybridization and immunostaining respectively.
Contrary to their previous results, Ubhi and Price found no difference in Oct-6 protein or mRNA expression between patients and controls.
BioMed Central
Ubhi and Price extended Price's original study to include patients with bipolar disorder and major depression - it has been suggested that schizophrenia shares a common pathology with these disorders. They analysed post-mortem brain samples from 3 groups of 15 patients. The first group had been diagnosed with schizophrenia, the second group with bipolar disorder and the third group with major depressive disorder. They used 15 brain samples of matched healthy individuals as controls. Oct-6 mRNA and protein expression were determined by in-situ hybridization and immunostaining respectively.
Contrary to their previous results, Ubhi and Price found no difference in Oct-6 protein or mRNA expression between patients and controls.
BioMed Central
Neural Development Current Events and Neural Development News RSSStanford scientist's new findings of autism-associated synapse alterations lead to coveted NIH grant
A Stanford University School of Medicine researcher has pinpointed the mechanism by which a gene associated with both autism and schizophrenia influences behavior in mice. And just recently, he received a $1.65 million government grant to expand his efforts to include many more such genes.
St. Jude scientists discover a new mechanism controlling neuronal migration
The molecular machinery that helps brain cells migrate to their correct place in the developing brain has been identified by scientists at St. Jude Children's Research Hospital.
Capturing the birth of a synapse
Researchers have identified the locking mechanism that allows some neurons to form synapses to pass along essential information.
Some neural tube defects in mice linked to enzyme deficiency
Women of childbearing age can reduce the risk of having a child born with a neural tube defect such as spina bifida by eating enough folate or folic acid. However, folate prevents only about 70 percent of these defects.
Brain protein central to both Parkinson's, drug addiction identified
Scientists have identified a protein that appears not only to be central to the process that causes Parkinson's disease but could also play a role in muting the high from methamphetamine and other addictive drugs.
Brain protein central to both Parkinson's, drug addiction identified
Scientists have identified a protein that appears not only to be central to the process that causes Parkinson's disease but could also play a role in muting the high from methamphetamine and other addictive drugs.
Heavy marijuana use may damage developing brain in teens, young adults
Adolescents and young adults who are heavy users of marijuana are more likely than non-users to have disrupted brain development, according to a new study.
EEGs show brain differences between poor and rich kids
University of California, Berkeley, researchers have shown for the first time that the brains of low-income children function differently from the brains of high-income kids.
New molecular insight into vertebrate brain development
In the December 1st issue of G&D, Dr. Fred H. Gage (The Salk Institute for Biological Studies) and colleagues reveal a role for the Hippo signaling pathway in the regulation of vertebrate neural development, identifying new factors - and potential therapeutic targets - that may be involved in congenital brain size disorders and neurological tumor formation.
Groundbreaking findings on autism to be presented at Carnegie Mellon international symposium
Today's autism research draws on a variety of scientific disciplines, from genetics to functional magnetic resonance imaging (fMRI) to neural development. At the 35th Carnegie Symposium on Cognition, "Development and Brain Systems in Autism," 16 of the world's most prominent autism researchers will present their latest groundbreaking findings on the disorder and discuss the direction of future study that will continue to improve scientists' understanding of autism.
More Neural Development Current Events and Neural Development News Articles
 |
Molecular and Cellular Approaches to Neural Development by W. Maxwell Cowan (Editor), Thomas M. Jessell (Editor), S. Lawrence Zipursky (Editor) This text provides a broad but authoritative view of the cellular and molecular aspects of developmental neurobiology written by leaders in the field. |
 |
Development of the Nervous System, Second Edition by Dan H. Sanes (Author), Thomas A. Reh (Author), William A. Harris (Author) Development of the Nervous System presents a broad treatment of the basic principles of neural development as exemplified by key experiments and observations from past and recent times. The text is organized ontogenically, beginning from the induction of the neural primordium and leading to the emergence of behavior. It covers all the major topics that would form the basis of a comprehensive undergraduate curriculum along the way including the patterning and growth of the nervous system, neuronal determination, axonal navigation and targeting, neuron survival and death, synapse formation and plasticity. The new text reflects the complete modernization of the field that has been achieved through the use of model organisms, the intensive application of molecular and genetic... |
 |
Vital Nutrients - Glycine Powder 250 gms by Vital Nutrients Vital Nutrients - Glycine Powder 250 gms Serving Size: 1/2 teaspoon = approx 2 grams Servings per container: 125 Glycine Powder 2000 mg Directions: One-half to one teaspoonful 1-2 times a day dissolved in water between or with meals or as directed by your healthcare professional. Warning: If pregnant consult your physician before taking this or any other product. Keep out of reach of children. Store sealed in a cool dry place. Does NOT contain: any binders, fillers, dairy, wheat, eggs, soy, yeast, corn, sugar, starch, preservatives or hydrogenated oil. |
 |
M-5 Neural Network Computer by Tech Center Labs Train Run Neural Networks on your Palm! |
|
The Development and Neural Bases of Higher Cognitive Functions (Annals of the New York Academy of Sciences) by Adele Diamond (Editor) | |
 |
Rethinking Innateness: A Connectionist Perspective on Development (Neural Networks and Connectionist Modeling) by Jeffrey L. Elman (Author), Elizabeth A. Bates (Author), Mark H. Johnson (Author), Annette Karmiloff-Smith (Author), Domenico Parisi (Author), Kim Plunkett (Author) Rethinking Innateness asks the question, "What does it really mean to say that a behavior is innate?" The authors describe a new framework in which interactions, occurring at all levels, give rise to emergent forms and behaviors. These outcomes often may be highly constrained and universal, yet are not themselves directly contained in the genes in any domain-specific way. One of the key contributions of Rethinking Innateness is a taxonomy of ways in which a behavior can be innate. These include constraints at the level of representation, architecture, and timing; typically, behaviors arise through the interaction of constraints at several of these levels. The ideas are explored through dynamic models inspired by a new kind of "developmental connectionism," a marriage of connectionist... |
 |
Vegan Omega-3 DHA 30 VegCaps by Deva Nutrition / 30 SoftGels by Deva Vegan Vitamins DEVA delivers high quality, potency and affordability all in one bottle. Our Vegan Omega-3 DHA oil comes in Vegan capsules. As an alternative to fish oil DEVA Omega-3 DHA is appreciated by vegans, vegetarians and anyone who would like to benefit from DHA in its safest form; derived from algae. Usage: For adults take one (1) Vegan capsule daily, or as directed by a health care professional. Although not required we suggest refrigeration after opening. |
 |
Principles of Neural Development by Dale Purves (Author), Jeff W. Lichtman (Author) |
 |
Neural Development and Stem Cells (Contemporary Neuroscience) by Mahendra S. Rao (Editor) This extensively expanded and updated edition reflects the enormous increase in our knowledge of the development of the nervous system. Working from a new understanding that the regionalization of stem cells occurs early in development and that this bias appears to persist even after prolonged culture, Dr. Rao has added additional chapters on olfactory epithelial stem cells and retinal stem cells, both of which differ in their properties from ventricular zone and subventricular zone-derived neural stem cells. A new chapter on cell death summarizes the important changes in the death pathway that occurs as stem cells mature. Special attention is paid to the derivation of neural cells from embryonic stem cells. Authoritative and up-to-date, "Neural Development and Stem Cells, Second Edition"... |
 |
Neural Development and Plasticity, Volume 108 (Progress in Brain Research) by R.R. Mize (Editor), R.S. Erzurumlu (Editor) This Progress in Brain Research volume is the outgrowth of a symposium entitled "Neural Development and Plasticity" which was held in New Orleans, Louisiana. The reader will find substantial new information about the mechanisms underlying growth cone dynamics, about molecules involved in axon outgrowth and cell adhesion, the role of proteoglycans and glial factors in directing or confirming axons to their appropriate targets, and the role of myelin-associated growth inhibitors. The book will contribute new ideas and identifies new questions of primary importance to developmental neurobiology. |
| © 2009 BrightSurf.com |