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Patients receiving supplemental oxygen during surgery have reduced risk of wound infection
October 26, 2005Patients who received a higher concentration of supplemental oxygen during colorectal surgery had a significantly reduced risk of wound infection, according to a study in the October 26 issue of JAMA.
Surgical wound infections prolong hospitalization by an average of 1 week and substantially increase the cost of care, according to background information in the article. These infections are possibly the most common serious complication of surgery and anesthesia. Supplemental oxygen during and after surgery has been variously reported to halve or double the risk of surgical wound infection.
F. Javier Belda, M.D., Ph.D., of the Hospital Clínico Universitario de Valencia, Spain, and colleagues conducted a study to determine whether supplemental perioperative (performed at or around the time of an operation) oxygen reduces the risk of wound infection. The double-blind, randomized controlled trial included 300 patients aged 18 to 80 years who underwent elective colorectal surgery in 14 Spanish hospitals from March 1, 2003, to October 31, 2004. Baseline patient characteristics, anesthetic treatment, and potential confounding factors were recorded. Patients were randomly assigned to an oxygen/air mixture with a fraction (concentration) of inspired oxygen (Fio2) of 30 percent or 80 percent intraoperatively and for 6 hours after surgery.
A total of 143 patients received 30 percent perioperative oxygen and 148 received 80 percent perioperative oxygen. Surgical site infection (SSI) occurred in 35 patients (24.4 percent) administered 30 percent Fio2, and in 22 patients (14.9 percent) administered 80 percent Fio2.
" we found that 80 percent supplemental oxygen reduced the risk of SSI by 39 percent. When controlling for multiple contributing factors, the reduction in SSI risk associated with 80 percent Fio2 was nearly 54 percent. Patients with infections had significantly longer hospital stays and delays to ambulation," the researchers write.
"This result is consistent with most available in vitro data and 1 other appropriately designed randomized controlled trial. Supplemental oxygen appears to confer few risks to the patient, has little associated cost, and should be considered part of ongoing quality improvement activities related to surgical care," the authors conclude.
JAMA and Archives Journals
A total of 143 patients received 30 percent perioperative oxygen and 148 received 80 percent perioperative oxygen. Surgical site infection (SSI) occurred in 35 patients (24.4 percent) administered 30 percent Fio2, and in 22 patients (14.9 percent) administered 80 percent Fio2.
" we found that 80 percent supplemental oxygen reduced the risk of SSI by 39 percent. When controlling for multiple contributing factors, the reduction in SSI risk associated with 80 percent Fio2 was nearly 54 percent. Patients with infections had significantly longer hospital stays and delays to ambulation," the researchers write.
"This result is consistent with most available in vitro data and 1 other appropriately designed randomized controlled trial. Supplemental oxygen appears to confer few risks to the patient, has little associated cost, and should be considered part of ongoing quality improvement activities related to surgical care," the authors conclude.
JAMA and Archives Journals
Supplemental Oxygen Current Events and Supplemental Oxygen News RSSMulticenter study led by pitt finds early results of therapy for preemies not sustained
Inhaled nitric oxide (iNO), a therapy used in the treatment of premature newborns with respiratory failure that had shown promising results in short-term studies, does not significantly improve long-term outcomes, according to a national study led by critical care researchers at the University of Pittsburgh School of Medicine and Children's Hospital of Pittsburgh of UPMC.
Study: Added oxygen during stroke reduces brain tissue damage
Scientists have countered findings of previous clinical trials by showing that giving supplemental oxygen to animals during a stroke can reduce damage to brain tissue surrounding the clot.
Coral bleaching increases chances of coral disease
Mass coral bleaching has devastated coral colonies around the world for almost three decades. Now scientists have found that bleaching can make corals more susceptible to disease and, in turn, coral disease can exacerbate the negative effects of bleaching.
Even mildly premature infants have increased risk of a common respiratory tract infection
Even mildly premature infants (gestational ages of 33 weeks through 36 weeks) have an increased risk of medically attended respiratory syncytial virus infection, which is the leading cause of lower respiratory tract infection in infants and young children and can lead to pneumonia in babies.
MedImmune presents new data showing burden of RSV disease
MedImmune today announced results from a recent study it sponsored, performed by the Kaiser Permanente Division of Research in Oakland, CA, assessing risk factors for respiratory syncytial virus (RSV) infection requiring medical treatment in infants born at 33 weeks gestational age [GA] or later.
Drops in blood oxygen levels may be key to sudden death in some epilepsy patients
A new study by researchers at UC Davis Medical Center suggests that the sudden unexplained deaths of some epilepsy patients may be a result of their brains not telling their bodies to breathe during seizures.
People with obstructive sleep apnea at risk for cardiac stress on airline flights
People with severe obstructive sleep apnea (OSA) on commercial airline flights may have a greater risk of adverse events from cardiac stress than healthy people.
Umbilical cord gene expression signals premature babies' lung disease risk
Diagnosing a risk of fatal lung disorders may be possible by analysing the umbilical cords of premature babies, according to research published in the online open access journal Genome Biology.
Ambulatory oxygen rarely a benefit in COPD patients without resting hypoxemia
Prescribing ambulatory oxygen in patients with chronic obstructive pulmonary disease (COPD) improves exercise performance, but not the quality of their daily life unless they have resting hypoxemia.
After scrutiny, preemie lung treatments turn out to be safe, effective
Preemies between 28 and 32 weeks are not harmed by a treatment no longer used to help their lungs mature before birth, according to findings of a study in this month's Pediatrics.
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