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New brain tumor model developed
October 31, 2005A collaboration of researchers, led by Dr. Martine Roussel (St. Jude Children's Research Hospital), has developed a novel mouse model of medulloblastoma - the most prevalent malignant pediatric brain tumor - that the researchers hope will more accurately represent the genetic changes involved in human brain tumor development.
Their study will be published in the November 15th issue of Genes & Development, but will also be made available online ahead of print on 10/31.
In their upcoming paper, the authors identify a heretofore unknown role for the cyclin-dependent kinase inhibitor, INK4C, in mediating medulloblastoma development, independent of p53 status. Using Ink4c-mutant mice, Dr. Roussel and colleagues demonstrated that Ink4c inactivation cooperates with mutations in Patched (Ptc1, a Shh receptor) to stimulate medulloblastoma formation, even when the p53 gene is intact.
Previously generated highly penetrant models of medulloblastoma rely on p53 loss for tumorigenesis, though in human patients, only about 10% of people actually display p53 mutations. "Preliminary data suggest that INK4c protein expression is diminished in a significant cohort of human medulloblastomas," says Dr. Roussel, "so the Pediatric Brain Tumor Program at our Institution is now planning to include a comprehensive survey of INK4c status in order to determine its prognostic significance."
Cold Spring Harbor Laboratory
Previously generated highly penetrant models of medulloblastoma rely on p53 loss for tumorigenesis, though in human patients, only about 10% of people actually display p53 mutations. "Preliminary data suggest that INK4c protein expression is diminished in a significant cohort of human medulloblastomas," says Dr. Roussel, "so the Pediatric Brain Tumor Program at our Institution is now planning to include a comprehensive survey of INK4c status in order to determine its prognostic significance."
Cold Spring Harbor Laboratory
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Adult survivors of childhood cancer are 20 to 25 percent more likely to never marry compared with siblings and the general population, Yale School of Medicine researchers report in a new study published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.
Brain tumors in childhood leave a lasting mark on cognition, life status
Brain tumors in childhood cast a long shadow on survivors. The first study of the lasting impact of these tumors -- the most common solid malignancies in childhood -- shows that survivors have ongoing cognitive problems.
Angiochem crosses BBB, shows safety, efficacy in phase 1/2 brain cancer studies
Angiochem, Inc. a clinical-stage biotechnology company developing drugs that are uniquely capable of crossing the blood-brain barrier to treat brain diseases, announced today that its lead drug candidate, ANG1005, has demonstrated a favorable safety and efficacy profile in more than 100 patients with brain cancer from two separate Phase 1 /2 clinical studies in patients with progressive gliomas, including recurrent glioblastoma, and in patients with progressive brain metastases.
Researchers report benefits of new standard treatment study for rare pediatric brain cancer
A team of researchers led by The University of Texas M. D. Anderson Cancer Center unveiled results today from the largest-ever collaborative study addressing the treatment of a rare pediatric brain tumor.
Unequal access: Hispanic children rarely get top-notch care for brain tumors
Hispanic children diagnosed with brain tumors get high-quality treatment at hospitals that specialize in neurosurgery far less often than other children with the same condition, potentially compromising their immediate prognosis and long-term survival, according to research from Johns Hopkins published in October's Pediatrics.
tudy: The new buzz on detecting tinnitus
It's a ringing, a buzzing, a hissing or a clicking - and the patient is the only one who can hear it. Complicating matters, physicians can rarely pinpoint the source of tinnitus, a chronic ringing of the head or ears that can be as quiet as a whisper or as loud as a jackhammer.
New Approach for the Treatment of Malignant Brain Tumors
Initial chemotherapy alone after surgery is just as successful as initial radiation therapy for patients from whom a very malignant brain tumor (anaplastic glioma) was removed. With this treatment, the patients survive on average > 30 months without a recurrence.
Weizmann Institute Scientists Discover A New Protein Partnership That Leads to Pediatric Tumor Regression
Why are some pediatric cancers able to spontaneously regress? Prof. Michael Fainzilber and his team of the Weizmann Institute's Biological Chemistry Department seem to have unexpectedly found part of the answer.
Why don't brain tumors respond to medication?
Malignant brain tumors often fail to respond to promising new medication. Researchers in Heidelberg have discovered a mechanism and a tumor marker for the development of this resistance.
NIH researchers identify key factor that stimulates brain cancer cells to spread
Researchers funded by the National Institutes of Health have found that the activity of a protein in brain cells helps stimulate the spread of an aggressive brain cancer called glioblastoma multiforme (GBM).
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