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A novel model to pinpoint human androgen receptor targets developed
November 01, 2005Computational prediction and experimental verification of androgen receptor binding within the prostate cancer genome
A novel computational model to pinpoint androgen receptor targets within the human genome was recently reported by the joint team of Genomatix Software GmbH, Munich, Germany (www.genomatix.de), and Center for Prostate Disease Research (CPDR), Uniformed Services University, Bethesda, Maryland, USA (www.cpdr.org). Identification of androgen receptor target sites is crucial for the understanding of prostate cancer that is the second leading cause of cancer related deaths among men. The unprecedented accuracy of the formula was achieved by training the computer to recognize common motifs within the regulatory sequences of androgen-inducible genes. It came as a surprise that the computer pointed to a composite model indicating consistently tight distance correlation between two transcription factor matrix families. Researchers in the collaborative team systematically tested and improved the model by experimentally verifying androgen receptor binding to predicted target sites within the prostate cancer genome. Results revealed a stunning concordance between computation and wetlab experiments. The teams led by Dr. Albert Dobi (CPDR) and by Dr. Thomas Werner (Genomatix GmbH), concluded on the pages of the Journal of Molecular Biology November 4th issue (JMB, vol. 353, pp.763, 2005) that composite models, biological context and the hand-in-hand application of computational and experimental biology can indeed yield superior tools for cancer biology.
Genomatix Software GmbH
Androgen Receptor Current Events and Androgen Receptor News RSSPET/CT scans may help detect recurring prostate cancer earlier
A new study published in the September issue of The Journal of Nuclear Medicine shows that positron emission tomography (PET)/computer tomography (CT) scans with the imaging agent choline could detect recurring prostate cancer sooner than conventional imaging technologies in some patients who have had their prostates surgically removed.
Study reveals a reprogrammed role for the androgen receptor
The androgen receptor - a protein ignition switch for prostate cancer cell growth and division - is a master of adaptability.
Protein that suppresses androgen receptors could improve prostate cancer diagnosis, treatment
A protein that helps regulate expression of androgen receptors could prove a new focal point for staging and treating testosterone-fueled prostate cancer, Medical College of Georgia researchers say.
New drug shows promise in treating drug-resistant prostate cancer
A new therapy for metastatic prostate cancer has shown considerable promise in early clinical trials involving patients whose disease has become resistant to current drugs.
Drug shows activity in men with advanced prostate cancer
A new multi-center study shows that an experimental drug lowers prostate specific antigen (PSA) levels - a marker for tumor growth - in men with advanced prostate cancer for whom traditional treatment options have failed.
New medications show promise in treating drug-resistant prostate cancer
A new therapy for metastatic prostate cancer has shown considerable promise in early clinical trials involving patients whose disease has become resistant to current drugs.
Castrate resistant prostate cancer: New therapeutic approaches
Today Dr. Martin Gleave of the Vancouver Prostate Centre in Canada gave a lecture about new approaches to treat castrate-resistant prostate cancer (CRCP) during the 24th Annual Congress of the European Association of Urology in Stockholm, Sweden.
Why prostate cancer patients fail hormone deprivation therapy
The hormone deprivation therapy that prostate cancer patients often take gives them only a temporary fix, with tumors usually regaining their hold within a couple of years.
Why a common treatment for prostate cancer ultimately fails
Some of the drugs given to many men during their fight against prostate cancer can actually spur some cancer cells to grow, researchers have found. The findings were published online this week in a pair of papers in the Proceedings of the National Academy of Sciences.
Blocking protein kills prostate cancer cells, inhibits tumor growth, Jefferson scientists find
Researchers at Jefferson's Kimmel Cancer Center in Philadelphia have shown that they can effectively kill prostate cancer cells in both the laboratory and in experimental animal models by blocking a signaling protein that is key to the cancer's growth.
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Androgens and Androgen Receptor: Mechanisms, Functions, and Clinical Applications by Chawnshang Chang (Editor) Androgen Receptors is the most comprehensive and up to date volume on the topic, including discussions of the basic mechanisms of androgen-androgen receptor actions, their roles in the androgen-related diseases, and their potential clinical applications. Key topics covered include: + The discovery and cloning of the androgen receptor; + Androgen receptor coregulators; + Androgen related genes and their consensus DNA response elements; + Basic mechanism of action including functional analyses, cellular localization and phosphorylation studies; + Cross-talk to other signal transduction systems; + The recent connections of androgens to women's diseases, such as osteoporosis and ovarian cancer. This book is of interest to students, basic scientists, and... |
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LG Sciences Androgen Receptor Upregulator, Capsules, 90 capsules by LG Sciences Dietary supplement. This is the most amazing supplement to ever hit the bodybuilding circuit. Receptor supercharges any product that is designed to supplement testosterone, including anabolic steroids, prohormones, anti-estrogen testosterone booster and even herbal test boosters. If you have ever done a cycle of steroids, you can't live without Receptor. It cleans out your androgen receptors which become less sensitive with each cycle. Used alone, Receptor will give you better gains by boosting your response to testosterone by up to 250% (according to studies) and increasing the number of androgen receptors. Used in combination with testosterone boosters, prohormones or steroids it will boost the effect by over 250% of those products! Finally, a totally natural way to increase receptor... |
![Androgens' performance-enhancing effects in the inhibitory avoidance and water maze tasks may involve actions at intracellular androgen receptors in the ... from: Neurobiology of Learning and Memory]](http://ecx.images-amazon.com/images/I/51T0MTGZBVL._SL160_.jpg) |
Androgens' performance-enhancing effects in the inhibitory avoidance and water maze tasks may involve actions at intracellular androgen receptors in the ... from: Neurobiology of Learning and Memory] by K.L. Edinger (Author), C.A. Frye (Author) This digital document is a journal article from Neurobiology of Learning and Memory, published by Elsevier in 2007. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser. Description: Androgens can have performance-enhancing effects in some cognitive tasks, but the mechanism of these effects has not been established. Experiments examined whether androgens' actions to bind to intracellular androgen receptors (ARs) in the hippocampus are necessary to enhance cognitive performance in the inhibitory avoidance and water maze tasks. If androgens' binding at ARs are essential, then blocking them through intrahippocampal administration of flutamide, an AR receptor antagonist, should... |
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Androgen Receptor-Interacting Proteins & Their Role in Androgen Regulated Transcription (Acta Biomedica Lovaniensia, 270) by Kurt Hofman (Author) |
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Interaction of organophosphate pesticides and related compounds with the androgen receptor. (Research).: An article from: Environmental Health Perspectives by Hiroto Tamura (Author), Hiromichi Yoshikawa (Author), Kevin W. Gaido (Author), Susan M. Ross (Author), Robert K. DeLisle (Author), William J. Welsh (Author), Ann M. Richard (Author) This digital document is an article from Environmental Health Perspectives, published by National Institute of Environmental Health Sciences on April 1, 2003. The length of the article is 8557 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Interaction of organophosphate pesticides and related compounds with the androgen receptor. (Research). Author: Hiroto Tamura Publication: Environmental Health Perspectives (Refereed) Date: April 1, 2003 Publisher: National Institute of Environmental Health Sciences Volume: 111 Issue: 4 Page: 545(8) Distributed by... | |
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Intrahippocampal administration of an androgen receptor antagonist, [An article from: Hormones and Behavior] by K.L. Edinger (Author), C.A. Frye (Author) This digital document is a journal article from Hormones and Behavior, published by Elsevier in 2006. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser. Description: Testosterone (T) and its 5@a-reduced metabolite, dihydrotestosterone (DHT), can decrease anxiety-like behavior; however, the mechanisms underlying these effects have not been established. First, we hypothesized that if T reduces anxiety-like behavior through actions of its 5@a-reduced metabolite, DHT, then gonadectomy (GDX) would increase anxiety-like behavior, an effect which would be reversed by systemic administration of DHT. Second, we hypothesized that if T and DHT reduce anxiety-like behavior in part... | |
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Androgen receptors are required for full masculinization of the ventromedial hypothalamus (VMH) in rats [An article from: Hormones and Behavior] by B.N. Dugger (Author), J.A. Morris (Author), C.L. Jordan (Author), Breedlove (Author) This digital document is a journal article from Hormones and Behavior, published by Elsevier in 2007. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser. Description: The ventromedial hypothalamus (VMH) is one of several sexually dimorphic nuclei that regulate mating behavior, and is rich in steroid hormone receptors and aromatase activity. We looked at the contribution of the androgen receptor (AR) to the volume of the VMH in rats by measuring each of the four subdivisions of the VMH in 90 day old male, female, and XY male rats carrying a mutant AR allele (tfm), which renders animals largely unresponsive to androgens. Confirming published reports, total VMH volume was... | |
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Social dominance regulates androgen and estrogen receptor gene expression [An article from: Hormones and Behavior] by S.S. Burmeister (Author), V. Kailasanath (Author), R.D. Fernald (Author) This digital document is a journal article from Hormones and Behavior, published by Elsevier in 2007. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser. Description: In Astatotilapia burtoni, dominant males have higher levels of sex steroid hormones than subordinate males. Because of the complex regulatory interactions between steroid hormones and receptors, we asked whether dominance is also associated with variation in sex steroid receptor gene expression. Using quantitative PCR, we compared the expression of specific subtypes of androgen (AR) and estrogen (ER) receptor genes between dominant and subordinated males in 3 divisions of the brain, the pituitary, and the... | |
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Androgens' effects to enhance learning may be mediated in part through actions at estrogen receptor-@b in the hippocampus [An article from: Neurobiology of Learning and Memory] by K.L. Edinger (Author), C.A. Frye (Author) This digital document is a journal article from Neurobiology of Learning and Memory, published by Elsevier in 2007. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser. Description: Testosterone (T) may enhance cognitive performance. However, its mechanisms are not well understood. First, we hypothesized that if T's effects are mediated in part through actions of its 5@a-reduced metabolites, dihydrotestosterone (DHT) and/or 3@a-androstanediol (3@a-diol) in the hippocampus, then T, DHT, and 3@a-diol-administration directly to the hippocampus should enhance learning and memory in the inhibitory avoidance task. In order to test this hypothesis, gonadectomized (GDX) male rats were... |
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Estradiol and bisphenol a stimulate androgen receptor and estrogen receptor gene expression in fetal mouse prostate mesenchyme cells.(Research): An article from: Environmental Health Perspectives by Catherine A. Richter (Author), Julia A. Taylor (Author), Rachel L. Ruhlen (Author), Wade V. Welshons (Author), Frederick S. vom Saal (Author) This digital document is an article from Environmental Health Perspectives, published by Thomson Gale on June 1, 2007. The length of the article is 6342 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Estradiol and bisphenol a stimulate androgen receptor and estrogen receptor gene expression in fetal mouse prostate mesenchyme cells.(Research) Author: Catherine A. Richter Publication: Environmental Health Perspectives (Magazine/Journal) Date: June 1, 2007 Publisher: Thomson Gale Volume: 115 Issue: 6 Page: 902(7) Distributed by Thomson... |
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