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Headlines about Herceptin show equality of access to costly drugs must be tackled
November 04, 2005
Adjuvant trastuzumab for breast cancer: we need to ensure that equity exists for access to effective and expensive treatments BMJ Vol 331, pp.1035-6 The recent press coverage on the use of Herceptin (brand name for the drug trastuzumab) for treating breast cancer in its early stages shows that issues of equal access to costly but effective drugs must be confronted, says an editorial in this week's BMJ.
Trastuzumab was "rapidly adopted as the standard of care" in the US for treating breast cancer, but one of the barriers to its use in other countries is its high cost, say the authors. In Canada the treatment costs $C50,000 a year (£25,000) per patient, and despite its effectiveness was not approved for funding in Ontario until after a media backlash.
The drug represents the first of probably many new cancer treatments of this kind, say the authors. The new hope it gives to patients also highlights new cost issues-both for the drugs themselves and surrounding cost of treatment.
Equality of patient access must extend to these accompanying areas, for example in diagnosing suitability for the drugs. Recent UK figures, for instance, show that only half of women are currently tested for the cancer gene targeted by the new treatment.
Healthcare systems around the world must no longer be left scrambling when effective new treatments come on the market. Transparent, timely and appropriately funded processes must be in place if patients are to get equal access to the best new treatments, conclude the authors.
BMJ-British Medical Journal
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Early-stage, HER2-positive breast cancer patients at increased risk of recurrence Early-stage breast cancer patients with HER2 positive tumors one centimeter or smaller are at significant risk of recurrence of their disease, compared to those with early-stage disease who do not express the aggressive protein, according to a study led by researchers at The University of Texas M. D. Anderson Cancer Center.
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Lombardi research: Monoclonal antibodies primed to become potent immune weapons against cancer New research suggests that monoclonal antibody therapy of cancer can be improved to be much more powerful than it is today, says a researcher at Georgetown University Medical Center's Lombardi Comprehensive Cancer Center in the March 21 issue of the Lancet. More Herceptin Current Events and Herceptin News Articles
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Her-2: The Making of Herceptin, a Revolutionary Treatment for Breast Cancer
by Robert Bazell (Author)
Two years after she underwent a mastectomy and chemotherapy, Barbara Bradfield's aggressive breast cancer had recurred and spread to her lungs. The outlook was grim. Then she took part in Genentech's clinical trials for a new drug. Five years later she remains cancer-free.
Her-2 is the biography of Herceptin, the drug that provoked dramatic responses in Barbara Bradfield and other women in the trials and that offers promise for hundreds of thousands of breast cancer patients. Unlike chemotherapy or radiation, Herceptin has no disabling side effects. It works by inactivating Her-2/neu--a protein that makes cancer cells grow especially quickly-- produced by a gene found in 25 to 30 percent of all breast tumors. Herceptin caused some patients' cancers to disappear...
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Living Proof
Starring: Regina King, Swoosie Kurtz, Amy Madigan, Tom Nowicki, Bernadette Peters Directed By: Dan Ireland
Top-rated Lifetime movie! Dr. Dennis Slamon has reached a breakthrough in his career. He has helped to develop a new experimental drug called Herceptin, which he hopes will become a revolutionary treatment in the fight against breast cancer. However, when funding for his project is cut, Slamon must turn to philanthropists Lilly Tartikoff and Ron Perelman to help make his life's most important work a reality. With the backing of his new supporters, Slamon continues to perfect his treatment, but his new drug proves that while it has the ability to give life, it does not work for everyone. This gut-wrenching true story explores one doctor's difficult struggle to find a cancer treatment that can save thousands of lives while giving meaning to his own life.
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Living Proof
Starring: Harry Connick Jr., Paula Cale, Angie Harmon, Bernadette Peters, Regina King Directed By: Dan Ireland, Dan Ireland Also With: Cathy M. Frank (Producer), Cathy M. Frank (Producer), Neil Meron (Producer), Neil Meron (Producer), Neil Meron (Producer), Neil Meron (Producer), Vivienne Radkoff (Producer), Vivienne Radkoff (Producer), Craig Zadan (Producer), Craig Zadan (Producer), Craig Zadan (Producer), Craig Zadan (Producer), Ren??e Zellweger (Producer)
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How Does Herceptin Work? A 3-D Animation
by Genentech (Author)
This is a DVD book--can be played as a standard DVD or on a computer.
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Charlie Rose with Robert Bazell, Larry Norton, Fran Visco & Lois Kasper; John Edgar Wideman (September 28, 1998)
First, Robert Bazell, author of Her 2, Dr. Larry Norton, oncologist at Memorial Sloan-Kettering Cancer Center, Lois Kasper of S.H.A.R.E, currently undergoing treatment for breast cancer with Herceptin, and Fran Visco, Chairwoman of the National Breast Cancer Coalition, sit down to talk about Herceptin as a treatment for breast cancer. Finally, John Edgar Wideman, known for his acclaimed stories of African-American life, discusses his new book, Two Cities- A Love Story, about his love of Philadelphia and Pittsburgh.This product is manufactured on demand using DVD-R recordable media. Amazon.com's standard return policy will apply.
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Expanded use of Herceptin.(Updates): An article from: FDA Consumer
by Gale Reference Team (Author)
This digital document is an article from FDA Consumer, published by Thomson Gale on March 1, 2007. The length of the article is 454 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.
Citation Details Title: Expanded use of Herceptin.(Updates) Author: Gale Reference Team Publication: FDA Consumer (Magazine/Journal) Date: March 1, 2007 Publisher: Thomson Gale Volume: 41 Issue: 2 Page: 4(2)
Distributed by Thomson Gale
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Optimising the Role of Herceptin in Breast Cancer (Supplement Issue: Oncology 2001, 2)
by D. Khayat (Editor)
The humanised monoclonal antibody Herceptin[registered] targets human epidermal growth factor receptor-2 (HER2) positive cells, i.e. cells in which HER2 is overexpressed, a feature associated with many tumour characteristics. Approximately 20-30 per cent of breast cancers are HER2 positive and are known to be particularly aggressive. Thus, HER2-positive clinical trials of Herceptin[registered] have clearly demonstrated that it provides significant clinical benefit in HER2-positive metastatic dis-ease, most importantly increased survival when administered first line in combination with chemotherapy. The articles in this supplement review our knowledge of the activity of HER2 and how to test for HER2 status, and describe the clinical trials of Herceptin[registered] that have been performed...
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Herceptin: An entry from Thomson Gale's Gale Encyclopedia of Cancer, 2nd ed.
by Lee Paradise (Author)
Students, researchers, and patients can find reliable, up-to-date and clearly written information in “The Gale Encyclopedia of Cancer,” a comprehensive survey of 120 cancers, cancer drugs, traditional and alternative treatments and diagnostic procedures.
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The hype over Herceptin.(LETTERS)(Letter to the editor): An article from: Kai Tiaki: Nursing New Zealand
by Jo Fitzpatrick (Author)
This digital document is an article from Kai Tiaki: Nursing New Zealand, published by New Zealand Nurses' Organisation on March 1, 2009. The length of the article is 655 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available immediately after purchase. You can view it with any web browser.
Citation Details Title: The hype over Herceptin.(LETTERS)(Letter to the editor) Author: Jo Fitzpatrick Publication: Kai Tiaki: Nursing New Zealand (Magazine/Journal) Date: March 1, 2009 Publisher: New Zealand Nurses' Organisation Volume: 15 Issue: 2 Page: 4(2)
Article Type: Letter to the editor
Distributed by Gale, a part of Cengage...
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Early Herceptin use cuts breast Ca recurrence in half: 'stunning' results when used as adjuvant tx.(News): An article from: OB GYN News
by Jane Salodof MacNeil (Author)
This digital document is an article from OB GYN News, published by Thomson Gale on June 15, 2005. The length of the article is 932 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.
Citation Details Title: Early Herceptin use cuts breast Ca recurrence in half: 'stunning' results when used as adjuvant tx.(News) Author: Jane Salodof MacNeil Publication: OB GYN News (Magazine/Journal) Date: June 15, 2005 Publisher: Thomson Gale Volume: 40 Issue: 12 Page: 1(2)
Distributed by Thomson...
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