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Promising advance in breast cancer research
November 15, 2005Two new drugs, when combined, killed up to 75 percent of breast cancer tumor cells in mice and suppressed the regrowth of tumors, according to researchers at the Virginia Commonwealth University Massey Cancer Center.
The findings, published online Nov. 14 in the journal Cancer Biology and Therapy, may also have implications for prostate cancer, lymphoma, myeloma and other hematologic cancers.
Paul Dent, Ph.D., associate professor of biochemistry and radiation oncology, led the team. This new study translates its 2002 research that showed early success in the lab and more recently was tested in animals.
In this new study, researchers combined two novel drugs, UCN-01 and a MEK 1/2 inhibitor, which are known to inhibit protein kinases, part of tumor survival signaling pathways.
"In addition to potently inhibiting cells and suppressing tumor growth, these drugs are also part of a modern class of drugs that are less toxic to non-cancerous cells," said Dent. "We are eager to move these exciting findings from the labs to patients."
When studied separately, the drugs only killed a small percent of the cells to which they were exposed. Combined, however, the result was quite startling.
"Within five days, we saw profound tumor cell death," Dent said. "Three researchers in the group operated the same studies independently, and they all saw very similar results."
Virginia Commonwealth University
In this new study, researchers combined two novel drugs, UCN-01 and a MEK 1/2 inhibitor, which are known to inhibit protein kinases, part of tumor survival signaling pathways.
"In addition to potently inhibiting cells and suppressing tumor growth, these drugs are also part of a modern class of drugs that are less toxic to non-cancerous cells," said Dent. "We are eager to move these exciting findings from the labs to patients."
When studied separately, the drugs only killed a small percent of the cells to which they were exposed. Combined, however, the result was quite startling.
"Within five days, we saw profound tumor cell death," Dent said. "Three researchers in the group operated the same studies independently, and they all saw very similar results."
Virginia Commonwealth University
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RNA snippet suppresses spread of aggressive breast cancer
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Large study documents how p53 mutations link to high-grade breast cancer, poor outcomes
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High blood pressure linked to earlier death among African-American breast cancer patients
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An Individualized Approach to Breast Cancer Treatment
Not all breast cancers are the same, and not all will have fatal consequences. But because clinicians find it difficult to accurately determine which tumors will metastasize, many patients do not receive the therapy fits their disease.
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Pink Snuggie Blanket - Purchase BenefitsThe Breast Cancer Research Foundation by Bewild - Pink Snuggie Blanket |
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Methods in Mammary Gland Biology and Breast Cancer Research by Margot M. Ip (Editor), Bonnie B. Asch (Editor) This book is a bench manual that provides in one volume all the important and unique technologies necessary to studies of mammary gland biology and breast cancer. The chapters are written by experts in each area with an emphasis on nitty-gritty details that are key points for the successful use of a method. Sections include in vivo model systems, special techniques for in vivo studies, in vitro model systems, and molecular analysis and gene transfer techniques. |
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Master Lock 1530DPNK Breast Cancer Research Foundation Dial Combination Lock, Pink by Master Lock |
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Trudeau Sablier 16-Ounce Tumbler, Breast Cancer Research Foundation Pink by Trudeau With the Sablier Tumbler you'll be able to keep your favorite hot or cold beverage with you and keep it hot or cold. This double wall insulated tumbler will keep your hot drink hot, for up to two hours. It has a convenient (and attractive) carry and go design and will hold up to 16-ounces of your favorite beverage. Because of the tumbler's innovative design and quality build you'll no longer have to worry about coffee or tea stains on your cloths, because it's leak free. It also features a non-slip base. Made with BPA-Free plastic. Pink colored stainless steel exterior, in support of Breast Cancer Research; a portion of proceeds go to the Breast Cancer Research Foundation. 5 year warrantee. By Trudeau a company that develops visionary products. Add an exciting flavor to your day, with... |
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Little Pink Drill $49-10% Donated to Breast Cancer Research! by Little Pink Tools 18 volt cordless rechargable drill specifically designed for women. Attractive and lightweight at only 3.25 lbs. Perfect for all your home maintenance! 1 year guarantee on drill, batteries and charger. |
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Bicycle Pink Breast Cancer Ribbon Playing Cards by USPC United States Playing Cards bicycle Buy these cards and a portion of every sale goes to the support of Breast Cancer Research foundation. Card Backs and Faces are Pink. |
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Swiss Army SwissCard Pink - Breast Cancer Awareness (Portion Donated to Research) by Victorinox SwissCards are so innovative that they won an award for highest design quality, expressing innovation in form and function. They make an excellent gift for any woman or girl, to keep in a purse or for school, work or home. A portion of the proceeds from the sale of this SwissCard goes toward breast cancer research. Features include: 1. Small blade/letter opener. 2. Useful scissors, 3-4. Mini-ruler (cm and inches), 5. Stainless steel pin, 6. Ballpoint pen, and 7. Tweezers. Made in Switzerland and guaranteed for life. |
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Pink Leather Lipstick Holder Supports Breast Cancer Research - Pink by Day-Timers Pink Leather Lipstick Holder Supports Breast Cancer Research Presenting our luxurious pink leather lipstick holder made of soft, pebble-grain leather exterior with rich, chocolate brown painted edges and chocolate suede interior. Keeps lipstick protected. Thanks to research and awareness programs, breast cancer survivors are living longer than ever before. Day-Timer will donate approximately 3-10% of the price of Pink Ribbon products to the Breast Cancer Research Foundation. To date, Day-Timer has contributed over $515,000. |
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Pink PedEgg For Breast Cancer Research Foundation!! |
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Rabbit Air BCRF Special Edition (model 421A - covers 600 sq. ft.) Ultra-Quiet Air Purifier w/ Germicidal Sterilization- Low Maintenance - Washable Filters!, Pearl White, 5% donation to The Breast Cancer Research Foundation by Rabbit Air Rabbit Air provides solutions for families concerned about their health and quality of life. A Los Angeles based company that plays a revolutionary role in the air purification industry, Rabbit Air manufactures environmentally friendly products with design in mind. Dedicated to designing state-of-the-art products that are highly effective, energy efficient and affordable, Rabbit Air purifiers are all based on HEPA filtration technology and do not produce ozone. |
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