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Patients regain cognitive function after radiation for brain tumors
November 16, 2005Patients who suffer from low-grade brain tumors are able to regain normal cognitive function after receiving radiation therapy to shrink their tumor, according to a study published in the November 15, 2005, issue of the International Journal of Radiation OncologyBiologyPhysics, the official journal of ASTRO, the American Society for Therapeutic Radiology and Oncology.
Prior to undergoing radiation therapy to treat their brain tumor, the 20 patients studied were submitted to a battery of intensive cognitive tests measuring intelligence, memory, learning and attention span to establish a baseline score to compare to future results. Following radiation therapy, patients were re-evaluated at 18-month intervals over the next five years. While the baseline test results were considered below average compared to age-specific norms, the first test after receiving radiation showed an increase in the group's overall score.
"These results suggest that the patients with brain tumors perform below average on these tests before radiation therapy because the tumor itself affects their cognitive skills," said Paul D. Brown, M.D., co-author of the study and a radiation oncologist at the Mayo Clinic in Rochester, Minn. "After the radiation, the brain function of the patients in the study went back to their normal, pre-tumor levels and stayed there for five years. This shows that a moderate dose of radiation, using modern techniques, does not cause cognitive injury in brain tumor patients."
Of the 20 patients, only one patient reverted back to their baseline scores three years after radiation therapy and across the board improvement was noted in immediate verbal memory, learning, long-term verbal memory, cognitive flexibility and spatial problem solving.
"Average life expectancy for these patients is three to 10 years and because there are no curative treatments for this type of cancer, a high priority is given to maintaining cognitive function and hence quality of life for as long as possible," said Brown. "This study shows that we can maintain and even improve the quality of life for someone suffering from a brain tumor."
American Society for Therapeutic Radiology and Onc
Of the 20 patients, only one patient reverted back to their baseline scores three years after radiation therapy and across the board improvement was noted in immediate verbal memory, learning, long-term verbal memory, cognitive flexibility and spatial problem solving.
"Average life expectancy for these patients is three to 10 years and because there are no curative treatments for this type of cancer, a high priority is given to maintaining cognitive function and hence quality of life for as long as possible," said Brown. "This study shows that we can maintain and even improve the quality of life for someone suffering from a brain tumor."
American Society for Therapeutic Radiology and Onc
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Mood improves on low-fat, but not low-carb, diet plan
After one year, a low-calorie, low-fat diet appears more beneficial to dieters' mood than a low-carbohydrate plan with the same number of calories.
Reduced muscle strength associated with risk for Alzheimer's
Individuals with weaker muscles appear to have a higher risk for Alzheimer's disease and declines in cognitive function over time, according to a report in the November issue of Archives of Neurology, one of the JAMA/Archives journals.
Preventative brain radiation for lung cancer patients: Benefits and risks
A new study is taking a closer look at the benefits versus risks for lung cancer patients to undergo preventative brain radiation therapy as a means to stop cancer from spreading to the brain.
Caltech researchers show efficacy of gene therapy in mouse models of Huntington's disease
Researchers at the California Institute of Technology (Caltech) have shown that a highly specific intrabody (an antibody fragment that works against a target inside a cell) is capable of stalling the development of Huntington's disease in a variety of mouse models.
Benefit of memantine in the treatment of Alzheimer's disease not proven
There is no scientific proof that patients with moderate or severe Alzheimer's disease benefit from drugs containing the agent memantine.
Fighting Sleep, Penn Researchers Reverse the Cognitive Impairment Caused By Sleep Deprivation
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First-time Internet users find boost in brain function after just 1 week
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Overweight middle-aged women cut chances of enjoying healthy old age
Women who put on weight as they approach middle-age could reduce their chances of enjoying a healthy old age by up to 80%, according to research from the University of Warwick.
Artificial intelligence helps diagnose cardiac infections
Mayo Clinic researchers say that "teachable software" designed to mimic the human brain may help them diagnose cardiac infections without an invasive exam.
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