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MR-Guided Laser Effective in Treating Liver Tumors
November 30, 2005CHICAGO-A large-scale, 12-year study has found that laser ablation with magnetic resonance (MR) guidance is as effective as traditional surgery in the treatment of liver tumors in some patients. The study was presented today at the annual meeting of the Radiological Society of North America (RSNA).
In the largest study of its type with the longest follow-up, 839 patients at the University of Frankfurt in Germany received MR-guided laser-induced thermotherapy (LITT) for the treatment of liver tumors resulting from colorectal cancer. Between 1993 and 2005, the researchers treated 2,506 liver tumors and tracked survival rates to evaluate the long-term results of the procedure. The average survival rate from the date of diagnosis was 3.8 years, which compares favorably to survival rates after traditional surgery (approximately 1.5 to 5.0 years).
In LITT, also known as laser ablation, laser light is used to destroy tumor tissue. According to the study's lead author, Martin Mack, M.D., laser ablation has many advantages over other treatment methods.
"Traditional surgical resection has higher morbidity and mortality rates than laser ablation," said Dr. Mack, an associate professor in the department of diagnostic and interventional radiology at the University of Frankfurt. "Laser treatment can be done on an outpatient basis under local anesthesia. Typically, the patient stays only a couple of hours, instead of a couple of weeks in the hospital after surgical liver resection," he said.
Laser ablation can be used to treat tumors that occur in both halves of the liver-often during the same treatment-which is practically impossible in a traditional surgery where typically only the left or right lobe is resected. If new tumors are found during follow-up exams, it is much easier to repeat laser treatment than to subject the patient to another open surgery.
Dr. Mack believes that laser combined with MR guidance will have wide-ranging impact on the treatment of tumors throughout the body, and may one day replace traditional surgery as the gold standard of treatment.
"Many surgeons are already performing local ablation instead of resection, because they have already recognized the positive effect of local ablation," he said. "I believe that minimally invasive tumor ablation together with chemotherapy will play the most important role in the treatment of tumors in the years to come."
Co-authors are Katrin Eichler, M.D., Thomas Lehnert, M.D., Dirk Proschek, M.D., Joern O. Balzer, M.D., and Thomas J. Vogl, M.D.
Radiological Society of North America
"Traditional surgical resection has higher morbidity and mortality rates than laser ablation," said Dr. Mack, an associate professor in the department of diagnostic and interventional radiology at the University of Frankfurt. "Laser treatment can be done on an outpatient basis under local anesthesia. Typically, the patient stays only a couple of hours, instead of a couple of weeks in the hospital after surgical liver resection," he said.
Laser ablation can be used to treat tumors that occur in both halves of the liver-often during the same treatment-which is practically impossible in a traditional surgery where typically only the left or right lobe is resected. If new tumors are found during follow-up exams, it is much easier to repeat laser treatment than to subject the patient to another open surgery.
Dr. Mack believes that laser combined with MR guidance will have wide-ranging impact on the treatment of tumors throughout the body, and may one day replace traditional surgery as the gold standard of treatment.
"Many surgeons are already performing local ablation instead of resection, because they have already recognized the positive effect of local ablation," he said. "I believe that minimally invasive tumor ablation together with chemotherapy will play the most important role in the treatment of tumors in the years to come."
Co-authors are Katrin Eichler, M.D., Thomas Lehnert, M.D., Dirk Proschek, M.D., Joern O. Balzer, M.D., and Thomas J. Vogl, M.D.
Radiological Society of North America
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Targeting Tumor Behavior May Lead To New Liver Cancer Drugs
Ohio State University cancer researchers have used computational and genomic methods to identify possible anti-cancer agents that may block a particular kind of tumor behavior.
Low-fat diet helps genetically predisposed animals avoid liver cancer
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Mayo Clinic identifies treatment target for liver cancer recurrence and survival
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MRI: A window to genetic properties of brain tumors
Doctors diagnose and prescribe treatment for brain tumors by studying, under a microscope, tumor tissue and cell samples obtained through invasive biopsy or surgery.
New Jefferson Trial to Test Radiation-Emitting Beads Against Advanced Liver Cancer
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High-energy ultrasound sharpens view of liver tumors
A high-energy form of ultrasound imaging developed by researchers at Duke University's Pratt School of Engineering produces pictures of liver tumors that are better than those made with traditional ultrasound, according to results of a clinical study.
Cell-death receptor links cancer susceptibility and inflammation
For over 10 years, Wafik S. El-Deiry, MD, PhD, Professor of Medicine, Genetics, and Pharmacology at the University of Pennsylvania School of Medicine, has been pursuing a cancer-targeting molecule called TRAIL and its molecular partners.
Einstein scientists treat cancer as an infectious disease -- with promising results
Researchers at the Albert Einstein College of Medicine of Yeshiva University have shown for the first time that cancers can be successfully treated by targeting the viruses that cause them.
Study shows radiofrequency ablation highly effective in treating kidney tumors
A relatively new, minimally invasive treatment was 100 percent successful in eradicating small malignant kidney tumors in a study of more than 100 patients, report researchers from Wake Forest University Baptist Medical Center.
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