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Scientists pool information to boost understanding of drug action
December 01, 2005A revamped international database, launched tomorrow, 1 December 2005 by The International Union of Basic and Clinical Pharmacology (IUPHAR) and hosted by the University of Edinburgh, has drawn together information on human genes that are targets for current and future medicines. The IUPHAR database http://www.iuphar-db.org/ has had a major update, following 12 years' work by 300 contributors. It is expected to be a major knowledge source for students and scientists throughout the world.
As a result of the Human Genome Project, scientists now know the human DNA codes for about 20,000-25,000 genes, each of which could be a target for the development of new medicines. However, most scientists believe that only about 10% of these genes are likely targets for the drugs of the future. More than 40% of the medicinal drugs in current use, many drugs of abuse and an estimated 20% of all future likely drug targets are members of three relatively small families of proteins: G Protein-coupled receptors (GPCRs), ion channels and nuclear hormone receptors. Drugs which work through GPCRs include treatments for asthma, ulcers and heart disease.
Professor Tony Harmar, Head of the School of Biomedical Sciences at the University said: "The Human Genome Project has sparked a huge effort by pharmaceutical and biotechnology companies worldwide to identify new drug targets and much of this effort has focused on the GPCRs. Our knowledge of this branch of science has advanced very rapidly and it has been difficult for scientists engaged in research in the field and in the teaching of the pharmacology - the science of drug action- to keep pace with the information explosion. The goal of the IUPHAR database is to provide information on all of the GPCRs, with information on the drugs that act on them, the targets in the body where they are found and the diseases in which they may be involved." Professor Michael Spedding, Chairman of NC-IUPHAR, commented: "The knowledge in this database is freely available to all scientists and drug discoverers throughout the world, and is a powerful tool for future research".
University of Edinburgh
University of Edinburgh
Drug Current Events and Drug News RSSU.S. and European Experts Applaud Creation of New Transatlantic Task Force on Global Antibiotic Resistance Threat
Experts on both sides of the Atlantic applaud President Barack Obama and Swedish Prime Minister Fredrik Reinfeldt, representing the European Union (EU) Presidency, for establishing a transatlantic task force to address antibiotic resistance, an urgent and growing problem that threatens patient safety and public health worldwide.
1930s drug slows tumor growth
Drugs sometimes have beneficial side effects. A glaucoma treatment causes luscious eyelashes. A blood pressure drug also aids those with a rare genetic disease.
DNA barcodes: Creative new uses span health, fraud, smuggling, history, more
The scientific ability to quickly and accurately identify species through DNA "barcoding" is being embraced and applied by a growing legion of global authorities - from medical and agricultural researchers to police and customs authorities to palaeontologists and others.
Higher carotid arterial stenting rates associated with poorer clinical outcomes
Among eligible Medicare beneficiaries, increased use of carotid arterial stenting (CAS) procedures to treat carotid stenosis-the narrowing of the carotid artery-is associated with higher rates of mortality and adverse clinical outcomes, including heart attack and stroke, according to researchers from the University of Pennsylvania School of Medicine.
SNM applauds House action to build medical isotopes reactor in the US
SNM applauds the U.S. House of Representatives for its passage of H.R. 3276-the American Medical Isotopes Production Act of 2009.
Local health investigation sheds light on gastroschisis birth defect
Results of an investigation conducted by University of Nevada, Reno researchers, public health officials and area physicians published this week in the Archives of Pediatrics & Adolescent Medicine, indicate that Washoe County experienced a cluster of a particular birth defect, gastroschisis, during the period April 2007 - April 2008.
NHLBI stops enrollment in study on resuscitation methods for cardiac arrest
Enrollment has ended early in a large, multicenter clinical trial comparing two distinct resuscitation strategies delivered by emergency medical service (EMS) providers to increase blood flow during cardiac arrest.
Possible help in fight against muscle-wasting disease
A compound already used to treat pneumonia could become a new therapy for an inherited muscular wasting disease, according to researchers at the University of Oregon and the University of Rochester School of Medicine and Dentistry in New York.
Researchers find new way to attack inflammation in Graves' eye disease
A small group of patients with severe Graves' eye disease experienced rapid improvement of their symptoms - and improved vision - following treatment with the drug rituximab.
Findings show nanomedicine promising for treating spinal cord injuries
Researchers at Purdue University have discovered a new approach for repairing damaged nerve fibers in spinal cord injuries using nano-spheres that could be injected into the blood shortly after an accident.
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