Science Current Events | Science News | Brightsurf.com
 
Email a Friend Send to a friend
Printer Friendly Print AMN107 has potent activity in leukemia resistant to Gleevec
Slashdot It! Slashdot AMN107 has potent activity in leukemia resistant to Gleevec
Submit to Reddit Submit AMN107 has potent activity in leukemia resistant to Gleevec to Reddit
Reading: AMN107 has potent activity in leukemia resistant to GleevecTwitter This Reading: AMN107 has potent activity in leukemia resistant to GleevecTwitter AMN107 has potent activity in leukemia resistant to Gleevec
Add to Facebook Add AMN107 has potent activity in leukemia resistant to Gleevec to Facebook

AMN107 has potent activity in leukemia resistant to Gleevec

December 12, 2005

The targeted agent AMN107 can produce dramatic benefits in patients with some forms of leukemia that are resistant to Gleevec, the standard therapy for these cancers, say researchers at The University of Texas M. D. Anderson Cancer Center (meeting abstract #37).

At the 47th Annual Meeting of the American Society of Hematology (ASH), the investigators reported marked improvement in outcome in all three phases of chronic myeloid leukemia (CML) as well as benefit in treating a form of acute lymphocytic leukemia (ALL) that shares the same genetic abnormality as CML, the Philadelphia chromosome.




"This drug is very promising and appears at this point to offer an effective option for patients who do not achieve an optimal response to Gleevec therapy," says Hagop Kantarjian, M.D., professor and chair of the Department of Leukemia.

If additional studies continue to show such results, Kantarjian says, he believes AMN107, which is taken in pill form, "will either replace Gleevec as the standard of care in the future or will be used in combination with it."

Both CML and Philadelphia-positive ALL is caused by the swapping of genetic material in bone marrow stem cells between two chromosomes, which produces an abnormality called the Philadelphia chromosome. This new gene then produces a novel tyrosine kinase (Bcr-Abl) that signals the abnormal cell growth that leads to development of leukemia.

While both Gleevec and AMN107 shut down the activity of Bcr-Abl, laboratory experiments with AMN107 show it is up to 50 times more potent because it binds more efficiently to the enzyme than does Gleevec.

In the phase I clinical trial being reported, 119 patients who were resistant to Gleevec were given AMN107, and in some cases the dose was increased up to twelve fold. The researchers found that the range of response varied, depending on the form of the cancer and the presence of genetic mutations. For example, hematologic response from the drug (defined as control of white blood cell counts) ranged from 44 percent to 100 percent in different subgroups of CML patients, and the more enduring cytogenetic response (elimination of cells with the cancer-causing defect) ranged from 22 percent to 100 percent. There was less overall response in ALL patients (ranging from 10 percent to 33 percent, depending on extent of disease).

Kantarjian notes that while some patients fared better than others with AMN107, these patients had little or no other treatment options available.

He says the results suggest that physicians soon will be able to tailor leukemia therapy according to the molecular profile of the disease, offering different treatments for subsets of patients based on their cancer's distinct molecular signature.

The collaborative study was led by M. D. Anderson and included the University of Frankfurt and Heidelberg University in Germany, the H. Lee Moffitt Cancer Center, Quest Diagnostics and Novartis Pharmaceuticals Corporation.

University of Texas M. D. Anderson Cancer Center





Science News and Science Current Events Tag Cloud
This tag cloud is a visual representation of term frequencies of random science news topics with common terms grouped together and emphasized by their display size.
Mastectomy   Fungus   Rotator Cuff   Ecstasy   Overweight Children   Diatoms   Ischemic Stroke   Aspirin   Angioplasty   Enzyme   HIV   Incontinence   Aggression   Type 2 Diabetes   Carbon Monoxide   Cholesterol Levels   Language Development   Drosophila   Idiopathic Pulmonary Fibrosis   Stroke   Mathematics   Anesthetics   Warfarin   Viruses   Cerebral Palsy  
Related Leukemia Current Events and Leukemia News Articles Leukemia Current Events and Leukemia News RSS Leukemia Current Events and Leukemia News RSS
Novel epigenetic markers of melanoma may herald new treatments for patients
Melanoma is the most serious form of skin cancer, diagnosed in more than 50,000 new patients in the United States annually. While the rate of incidences continues to rise, survival rate has not improved and the race is on to find the genetic and cellular changes driving melanoma and to devise new means of detection and treatment.

Researchers pinpoint a new enemy for tumor-suppressor p53
Researchers at The University of Texas M. D. Anderson Cancer Center have identified a protein that marks the tumor suppressor p53 for destruction, providing a potential new avenue for restoring p53 in cancer cells.

Children's Hospital Oakland scientists first to discover new source for harvesting stem cells
A groundbreaking study conducted by Children's Hospital & Research Center Oakland is the first to reveal a new avenue for harvesting stem cells from a woman's placenta, or more specifically the discarded placentas of healthy newborns.

A new weapon in the war against HIV-AIDS: Combined antiviral and targeted chemotherapy
A discovery by a team of Canadian and American researchers could provide new ways to fight HIV-AIDS. According to a new study published in Nature Medicine, HIV-AIDS could be treated through a combination of targeted chemotherapy and current Highly Active Retroviral (HAART) treatments.

Research uncovers clues to virus-cancer link
In a series of recently-published articles, a research team from the University of North Carolina at Chapel Hill Lineberger Comprehensive Cancer Center has uncovered clues to the development of cancers in AIDS patients.

UCLA cancer researchers develop model that may help identify cancer stem cells
Researchers at UCLA's Jonsson Comprehensive Cancer Center, on a quest to find lung cancer stem cells, have developed a unique model to allow further investigation into the cells that many believe may be at the root of all lung cancers.

Dual role in breast tissue for a protein involved in leukemia
A protein known to play a role in growth of some types of leukemia appears to have a mixed function in breast cancer development, say researchers from the Lombardi Comprehensive Cancer Center at Georgetown University Medical Center (GUMC).

A lethal cancer knocked down by one-two drug punch
In the battle against cancer, allies can come from unexpected sources. Research at The Jackson Laboratory has yielded a new approach to treating leukemia, one that targets leukemia-proliferating cells with drugs that are already on the market.

Stem cell protein offers a new cancer target
A protein abundant in embryonic stem cells is now shown to be important in cancer, and offers a possible new target for drug development, report researchers from the Stem Cell Program at Children's Hospital Boston.

1 in 10 advanced colon cancer patients worry about prescription drug costs
The vast majority of advanced colon cancer patients in a clinical trial were not concerned about the cost of prescription drugs for managing chemotherapy side effects, such as infection, pain and nausea and few adopted strategies to reduce drug cost burdens after joining the clinical trial.
More Leukemia Current Events and Leukemia News Articles
100 Q&A About Leukemia, Second Edition (100 Questions & Answers about)

100 Q&A About Leukemia, Second Edition (100 Questions & Answers about)
by Edward D. Ball (Author)

This book deals with leukemia from a doctor's and a patient's perspective.

Childhood Leukemia: A Guide for Families, Friends and Caregivers (3rd Edition)

Childhood Leukemia: A Guide for Families, Friends and Caregivers (3rd Edition)
by Nancy Keene (Author)

This most complete parent guide available covers not only detailed and precise medical information about leukemia and the various treatment options, but also day-to-day practical advice on how to cope with procedures, hospitalization, family and friends, school, social and financial issues, communication, feelings, and, if therapy is not successful, the difficult issues of death and bereavement. Woven among the medical details and the practical advice are the voices of parents and children who have lived with leukemia and its treatments. As many parents have already found, advice from "veteran" parents can be a lifeline.This third edition contains significant updates to the information on treatments, chemotherapy drugs, bone marrow transplants, coping with side effects, and resources. It...

Understanding MDS/Leukemia

Understanding MDS/Leukemia

Part of the award winning public television series Healthy Body/Healthy Mind. It can begin as a harmless case of fatigue but can lead to a blood transfusion or possible bone marrow transplant. It's a disease virtually unknown to the general public and often not diagnosed by medical caregivers. Mylodysplastic syndrome, or MDS, is a disorder of the bone marrow and can lead to leukemia and eventually death. In this program, success stories abound as researchers struggle to find answers.

This product is manufactured on demand using DVD-R recordable media. Amazon.com's standard return policy will apply.

Adult Leukemia: A Comprehensive Guide for Patients and Families

Adult Leukemia: A Comprehensive Guide for Patients and Families
by Barbara Lackritz (Author)

For the tens of thousands of Americans with adult leukemia, the condition, which is really a group of diseases, is often a baffling one for patients and families to understand, and finding targeted information on individual conditions can be difficult. In straightforward language, Adult Leukemia: A Comprehensive Guide for Patients and Families addresses: Diagnosis and medical testsFinding a good oncologistTreatmentsSide effectsEmotional responses to diagnosis, treatment, remission, possible recurrenceGetting support from your family, friends, employers, and the broader community Author Barb "Grannybarb" Lackritz is a leading patient activist in the leukemia community and herself a long-term leukemia survivor. She emphasizes the promising emerging treatments for leukemia, covering in...

Walking with a Shadow: Surviving Childhood Leukemia

Walking with a Shadow: Surviving Childhood Leukemia
by Praeger Publishers

Childhood cancer, particularly leukemia, is on the rise. Leukemia strikes one child in every 25,000, and most often does so between the ages of 3 and 7. Annually, more than 2,700 children are diagnosed with leukemia in the United States. Due to advances in biotechnology and medicine, survival rates for this once-deadly disease now stand at 80%. But the psychological effects of diagnosis, removal from school, treatment, and remission or cure, linger. Here nine long-term survivors of childhood leukemia share their vivid memories and give us insight into the physiological changes, psychosocial and educational difficulties that became a constant "shadow" in their lives. Author Nanci Sullivan provides recommendations for ways teachers, counselors and other professionals may better help young...

Living Through Leukemia: A Journey to Health

Living Through Leukemia: A Journey to Health
by Louis George Whitehead (Author)

While many believe that being diagnosed with leukemia is like being handed a death sentence, South Dakota native Louis George Whitehead provides living proof that survival of this life-threatening and life-changing illness is possible.

At age twenty-one, Whitehead’s doctor informs him that he is suffering from acute myeloid leukemia. After two rounds of chemotherapy and a relapse a few months later, Whitehead makes the decision to undergo a bone-marrow transplant. Living through Leukemia chronicles his story of endurance and optimism.

Whitehead shares his feelings following his initial diagnosis and through the realization that a fatal outcome was possible. He also details the events and symptoms leading up to his courageous battle and describes the importance of both his...

Cure Leukemia Awareness Long Sleeve T-shirt Large White

Cure Leukemia Awareness Long Sleeve T-shirt Large White



Assure FeLv Feline Leukemia Virus Antigen Test Kit 25 tests

Assure FeLv Feline Leukemia Virus Antigen Test Kit 25 tests
by Synbiotics Corporation

A non-invasive saliva test accurate enough for general FeLv testing, pre-vaccination & health screens. Ideal for detection of viral shedding or to confirm blood ELISA positives. This versatile diagnostic tool utilizes saliva, whole blood, plasma or serum. Pre-measured reagents plus your sample. Must be refrigerated until ready to use. Warm to room temp before using.

Leukemia (The Biology of Cancer)

Leukemia (The Biology of Cancer)
by Donna M. Bozzone (Author)

This book includes full-color photographs, glossary, sidebars, further reading, web sites, references, and an index. Leukemia, or cancer of the blood or bone marrow, occurs in both acute and chronic forms. While the exact causes of the disease are not known, several risk factors have been identified. There are four major types of leukemia: acute myeloid leukemia (AML), chronic myeloid leukemia (CML), acute lymphoid leukemia (ALL), and chronic lymphoid leukemia (CLL), and treatments include chemotherapy, radiation, and bone marrow transplants. "Leukemia" discusses the science of leukemia, theories about its causes, the history of the disease, and the current treatments and how they work.

Leukemia Awareness Green Genuine Swarovski Crystal Bracelet

Leukemia Awareness Green Genuine Swarovski Crystal Bracelet

This Beautiful Green Genuine Swarovski Crystal Bracelet Is the Perfect Bracelet you have been waiting for. It has a Sparking Glimmer and is beaded on a Comfort Stretch band. Looks great when worn with a few at a time or alone. Crystal beads can also be used to create your own jewelry! Very Stylish and Pretty!

© 2009 BrightSurf.com