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200 proteins which detect diseases of the liver
December 14, 2005The biochemist Enrique Santamaría Martínez, a researcher in the area of Genetic Therapy and Hepatology at the CIMA of the University of Navarra, has identified more than 200 proteins which can be considered as indicators of the progression of steatohepatitis and liver hepatitis. In addition, these proteins provide a basis for new lines of research which can develop clinical application strategies for improving the diagnosis and treatment of this cancer. This research forms part of his doctoral thesis, which was presented at the School of Sciences.
As Dr. Santamaría explains, the study of liver diseases is one of the primary objectives of biomedicine today, given the growing prevalence of these pathologies among the population. Although the risk factors are well known, such as genetic factors and excessive consumption of alcohol, the mechanisms which participate in the development of the disease are not so well known.
When he concluded his research, he noted that "one of the biomarkers, in particular the oxidized form of the apolipoprotein A1, has been detected in the blood serum of liver cancer patients. For this reason it is especially relevant in the area of diagnosis".
Proteomics: new technologies for studying proteins
The work of Dr. Enrique Santamaría allows clinical practitioners to discover "the alteration of proteins in the liver and, as a result, to discern the biological malfunctions associated with them, at a much earlier stage than permitted by conventional diagnostic methods alone". This is the case with prohibitin, a protein involved in the generation of energy for the maintenance of cellular activity, or with regucalcin, a protein involved in the control of cellular aging, among others.
For the research he performed at the CIMA of the University of Navarra, he used new technologies, such as proteomics. "This technique allows the study of hundreds of proteins simultaneously, and in this way we can define the natural history of diseases at the molecular level, and can identify markers which facilitate the diagnosis and treatment of these sicknesses\\\
Elhuyar Fundazioa
Proteomics: new technologies for studying proteins
The work of Dr. Enrique Santamaría allows clinical practitioners to discover "the alteration of proteins in the liver and, as a result, to discern the biological malfunctions associated with them, at a much earlier stage than permitted by conventional diagnostic methods alone". This is the case with prohibitin, a protein involved in the generation of energy for the maintenance of cellular activity, or with regucalcin, a protein involved in the control of cellular aging, among others.
For the research he performed at the CIMA of the University of Navarra, he used new technologies, such as proteomics. "This technique allows the study of hundreds of proteins simultaneously, and in this way we can define the natural history of diseases at the molecular level, and can identify markers which facilitate the diagnosis and treatment of these sicknesses\\\
Elhuyar Fundazioa
Liver Disease Current Events and Liver Disease News RSSLargest-ever database for liver proteins may lead to treatments for hepatitis
Scientists at a group of 11 research centers in China are reporting for the first time assembly of the largest-ever collection of data about the proteins produced by genes in a single human organ.
Alcohol Tolerance Switch Found in Fruit Flies
Researchers at North Carolina State University have found a genetic "switch" in fruit flies that plays an important role in making flies more tolerant to alcohol.
Scientists develop novel method to generate functional hepatocytes for drug testing
Scientists have for the first time produced liver cells from adult skin cells using the induced pluripotent stem cell (iPSC) technology.
UCSD researchers pave the way for effective liver treatments
A combination of bioengineering and medical research at the University of California, San Diego has led to a new discovery that could pave the way for more effective treatments for liver disease.
Governor recognizes stem cell research at Einstein
Albert Einstein College of Medicine of Yeshiva University hosted a roundtable discussion on stem cell research with New York Governor David A. Paterson today.
Liver cells grown from patients' skin cells
Scientists at The Medical College of Wisconsin in Milwaukee have successfully produced liver cells from patients' skin cells opening the possibility of treating a wide range of diseases that affect liver function.
Metabolic syndrome linked to liver disease in obese teenaged boys
Researchers studying a large sample of adolescent American boys have found an association between metabolic syndrome, which is a complication of obesity, and elevated liver enzymes that mark potentially serious liver disease.
Penn State College of Medicine research isolates liver cancer stem cells prior to tumor formation
Penn State College of Medicine researchers, in collaboration with colleagues at the University of Southern California, have taken an important step in understanding the role of stem cells in development of liver cancer.
Genetic hint for ridding the body of hepatitis C
More than seventy percent of people who contract Hepatitis C will live with the virus that causes it for the rest of their lives and some will develop serious liver disease including cancer.
HBV genotype B/B3 and C/C1 are the major genotypes in Indonesia?
Previous studies revealed that HBV genotypes as well as mutations in the core promoter, precore or HBx gene have been shown to have an association with the clinical outcome of liver disease, however, this is still controversial.
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