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Adults with lazy eye can improve
December 21, 2005New treatment offers promise for previously incurable condition
Young adults with amblyopia, or lazy eye, can improve substantially and retain their gains under a new treatment developed by researchers at USC and three Chinese universities.
A lazy eye in children appears normal but does not see properly, even with corrective lenses. If untreated, the eye will not develop fully, resulting in permanent loss of vision.
Amblyopia has been considered incurable in children older than eight. The new study, published online by Vision Research, documented a 70 percent improvement in eye chart performance in 19-year-old subjects. The average one-year retention rate was 90 percent.
The researchers trained the subjects in detection of a small "gabor" (pronounced ga-BOR), a set of three contrasting dark and light ovals that neurophysiologists have identified as a basic unit of visual perception.
Surprisingly, improvement in this abstract exercise generalized to a marked improvement in standard vision tests. The seven subjects improved their overall visual acuity 25 to 216 percent, with an average of 70 percent.
Another 10 subjects in a slightly different training program showed an average improvement of 46 percent. Eight subjects in a control group showed no improvement.
"Detecting simple visual patterns turned out to be quite useful for improving visual acuity for amblyopia patients, typically measured by eye chart reading," said co-author Zhong-Lin Lu, professor of psychology in the USC College of Letters, Arts and Sciences and co-director of the Dornsife Neuroscience Imaging Center.
"You train on one of these gabors, you can generalize this to a whole bunch of different gabors, and also generalize this to an eye chart. That makes it [the training] useful," Lu said.
Normal subjects who received the same training did not show a general improvement in vision. A possible reason may be that a little stimulus goes a long way toward awakening the amblyopic eye, Lu said.
Amblyopia is sometimes due to a misaligned eye that can be reoriented surgically. But in many cases the eye is perfectly healthy, Lu said, who added, "The problem is actually in the brain. This is a neural deficit."
Next, the researchers plan to test their method on patients at a clinic in China. Other plans include developing a home training program.
"It could become a clinical procedure," Lu said.
University of Southern California
Amblyopia has been considered incurable in children older than eight. The new study, published online by Vision Research, documented a 70 percent improvement in eye chart performance in 19-year-old subjects. The average one-year retention rate was 90 percent.
The researchers trained the subjects in detection of a small "gabor" (pronounced ga-BOR), a set of three contrasting dark and light ovals that neurophysiologists have identified as a basic unit of visual perception.
Surprisingly, improvement in this abstract exercise generalized to a marked improvement in standard vision tests. The seven subjects improved their overall visual acuity 25 to 216 percent, with an average of 70 percent.
Another 10 subjects in a slightly different training program showed an average improvement of 46 percent. Eight subjects in a control group showed no improvement.
"Detecting simple visual patterns turned out to be quite useful for improving visual acuity for amblyopia patients, typically measured by eye chart reading," said co-author Zhong-Lin Lu, professor of psychology in the USC College of Letters, Arts and Sciences and co-director of the Dornsife Neuroscience Imaging Center.
"You train on one of these gabors, you can generalize this to a whole bunch of different gabors, and also generalize this to an eye chart. That makes it [the training] useful," Lu said.
Normal subjects who received the same training did not show a general improvement in vision. A possible reason may be that a little stimulus goes a long way toward awakening the amblyopic eye, Lu said.
Amblyopia is sometimes due to a misaligned eye that can be reoriented surgically. But in many cases the eye is perfectly healthy, Lu said, who added, "The problem is actually in the brain. This is a neural deficit."
Next, the researchers plan to test their method on patients at a clinic in China. Other plans include developing a home training program.
"It could become a clinical procedure," Lu said.
University of Southern California
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Update on vitamins and diabetic retinopathy; ethnic norms for preschoolers' eyesight
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Serious vision problems in urban preschoolers rare but not that rare, Hopkins study shows
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USC study -- largest of its kind -- finds older children more likely to develop vision disorders
In a study of more than 6,000 Los Angeles-area children - the largest study of its kind - researchers at the Keck School of Medicine of the University of Southern California (USC) found that both strabismus (commonly known as cross-eyed or wall-eyed) and amblyopia (often referred to as lazy eye) were more prevalent in older children than in younger children.
Early treatment of children with bilateral amblyopia essential, according to multisite study
When a child is farsighted or has astigmatism or has both conditions in both eyes, bilateral amblyopia may develop. In contrast to single-eye amblyopia or "lazy eye," where one eye presents an unclear image to the brain, bilateral amblyopia affects both eyes and is less common.
No need for children with lazy eye to wear patches all day
Children with amblyopia (commonly known as lazy eye) need only wear an eye patch for three to four hours a day for 12 weeks to improve vision, say researchers in a study published on bmj.com today.
Fine motor skills, social acceptance lower in children with 'lazy eye'
A recent study evaluating the fine motor skills and perceived self esteem of children with amblyopia (or "lazy eye") compared with age-matched children will be presented during the Association for Research in Vision and Ophthalmology (ARVO) 2007 Annual Meeting in Fort Lauderdale, Fla.
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