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ICS most effective for persistent asthma in children
January 11, 2006While both inhaled corticosteroids (ICS) and leukotriene receptor antagonists (LTRA) have been proven to help control mild-to-moderate persistent asthma in school-age children, a new study shows ICS may be the more effective treatment.
Response Profiles to Fluticasone and Montelukast in Mild-to-Moderate Persistent Childhood Asthma is featured in the January 2006 issue of the Journal of Allergy & Clinical Immunology (JACI) and is currently available on the JACI's Web site at www.jacionline.org. The JACI is the peer-reviewed, scientific journal of the American Academy of Allergy, Asthma and Immunology (AAAAI).
The 16-week study was conducted as a multi-center, double-masked, 2-sequence crossover trial by the National Heart, Lung and Blood Institute (NHLBI) Childhood Asthma Research and Education (CARE) Network. Researchers, led by Robert S. Zeiger, MD, PhD, from the University of California San Diego Department of Pediatrics, administered an ICS (fluticasone propionate) twice daily or an LTRA (montelukast) nightly to more than 100 children ages 6 to 17 who had mild-to-moderate persistent asthma.
Researchers found both fluticasone and montelukast led to significant improvements in many measures of asthma control. However, similar to earlier research, they found strong evidence of greater mean improvements after 8 weeks of therapy with an ICS compared with a LTRA across many other outcomes.
Patients taking ICS experienced more asthma control days (ACD) in which they had no daytime or night time asthma symptoms, along with better pulmonary responses and inflammatory biomarkers. As a comparison, 29.3 % of participants had at least one more ACD per week during treatment with fluticasone than during treatment with montelukast (12.2 %).
American Academy of Allergy, Asthma & Immunology
Researchers found both fluticasone and montelukast led to significant improvements in many measures of asthma control. However, similar to earlier research, they found strong evidence of greater mean improvements after 8 weeks of therapy with an ICS compared with a LTRA across many other outcomes.
Patients taking ICS experienced more asthma control days (ACD) in which they had no daytime or night time asthma symptoms, along with better pulmonary responses and inflammatory biomarkers. As a comparison, 29.3 % of participants had at least one more ACD per week during treatment with fluticasone than during treatment with montelukast (12.2 %).
American Academy of Allergy, Asthma & Immunology
ICS Current Events and ICS News RSSNew findings could help hybrid, electric cars keep their cool
Understanding precisely how fluid boils in tiny "microchannels" has led to formulas and models that will help engineers design systems to cool high-power electronics in electric and hybrid cars, aircraft, computers and other devices.
New breathing exercises help manage asthma
A presentation that demonstrates breathing exercises designed to help reduce the use of asthma inhalers is today available to the general public for free from the Cooperative Research Centre (CRC) for Asthma and Airways website.
Each finger can be moved separately
A new prosthetic hand is being tested at the Orthopedic University Hospital in Heidelberg / Grip function almost like a natural hand.
Microchip fingerprints used to lock out chip pirates
Pirated microchips -- chips stolen from legitimate factories or made from stolen blueprints -- account for billions of dollars in annual losses to chipmakers.
High-dose inhaled corticosteroid use for COPD could cut risk of lung cancer
Among a group of mostly older male veterans suffering from chronic obstructive pulmonary disease (COPD), an illness that offers a greater susceptibility to lung cancer, researchers found that regular use of high dose inhaled corticosteroids (ICS) lowered the risk of developing lung cancer.
Combination therapy reduces exacerbations in severe COPD
For patients with severe chronic obstructive pulmonary disease (COPD), combining a long-acting bronchodilator with an inhaled corticosteroid reduced the number of exacerbations by 35 percent.
Transfusion-free surgical program reduced use of blood products for all liver transplant patients
Development of a transfusion-free surgical program for Jehovah's Witness patients undergoing liver transplantation also has helped reduce the overall use of blood products for non-Jehovah's Witnesses undergoing the procedure.
Literature review highlights options for self-management of asthma exacerbations
An extensive literature review undertaken by the Woolcock Institute of Medical Research has examined the pharmacological strategies for self-management of asthma exacerbations in adults, including those using inhaled corticosteroid/long-acting â2-agonist (ICS/LABA) therapy.
Repeatable low-breakdown voltage antifuses enabled through a Sandia-developed dielectric thin film
Researchers at Sandia National Laboratories have developed an inexpensive, reliable and easy-to-manufacture class of dielectric films that have the capability of enabling programmable antifuses on integrated circuits (IC) at less cost and using easier-to-manufacture methods.
Inhaled steroids preferred over cromolyn to treat asthma
Adults and children with asthma will breathe deeper and have better control over their asthma with inhaled corticosteroids than with the medicine cromolyn, according to a new review of recent studies comparing the two treatments.
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