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New insights into neural tube defects
January 12, 2006Environmental and genetic factors lead to neural tube defects in 1 in every 1,000 births and cause 1 in 20 of every spontaneous abortion. One cause of these defects is the failure of cells within the neural tube to migrate to the middle of the developing neural tube.
A study in this week's issue of Nature is the first to report on the molecular mechanism that directs cells to migrate to the correct local within the developing neural tube of vertebrates.
Marek Mlodzik, PhD, Professor, Molecular, Cell and Development Biology at Mount Sinai School of Medicine has previously reported that the asymmetrical distribution of specific proteins within neural tissues in fruit flies controls the orientation and migration of cells.
Working with colleagues Brian Ciruna, Diana Lee, and Alexander Schier, who were at New York University when the research was conducted, and Andreas Jenny of Mount Sinai, Dr. Mlodzik's and Dr. Schier's laboratories have now found that a similar mechanism is at work in vertebrates.
During cell division the polarity of a cell is lost. Therefore, the newly formed daughter cells initially lack the information to direct them to migrate to the midline where they are needed for proper neural tube development. The report in Nature is the first to demonstrate that the polarity is restored to the daughter cells after rather than during cell division and to provide the specific molecules involved in restoring polarity.
After cell division, proteins that direct the polarity of the cell distribute asymmetrically. This distribution restores polarity in the daughter cell, directing them to migrate to the midline of the neural tube.
The Mount Sinai Hospital / Mount Sinai School of Medicine
Working with colleagues Brian Ciruna, Diana Lee, and Alexander Schier, who were at New York University when the research was conducted, and Andreas Jenny of Mount Sinai, Dr. Mlodzik's and Dr. Schier's laboratories have now found that a similar mechanism is at work in vertebrates.
During cell division the polarity of a cell is lost. Therefore, the newly formed daughter cells initially lack the information to direct them to migrate to the midline where they are needed for proper neural tube development. The report in Nature is the first to demonstrate that the polarity is restored to the daughter cells after rather than during cell division and to provide the specific molecules involved in restoring polarity.
After cell division, proteins that direct the polarity of the cell distribute asymmetrically. This distribution restores polarity in the daughter cell, directing them to migrate to the midline of the neural tube.
The Mount Sinai Hospital / Mount Sinai School of Medicine
Neural Tube Defects Current Events and Neural Tube Defects News RSSEssential nutrient found in eggs may help lower risk of neural tube defects
Research published online in the journal Epidemiology found that higher levels of total blood choline are associated with a 2.5-fold reduction in risk for neural tube birth defects (NTDs).
Irish-led research team rule out link between specific antibodies and spina bifida
New research, published today in the New England Journal of Medicine, shows that a woman's risk of having a child with a neural tube defect (NTD), such as Spina Bifida, is not linked to folic acid related auto-antibodies.
Some neural tube defects in mice linked to enzyme deficiency
Women of childbearing age can reduce the risk of having a child born with a neural tube defect such as spina bifida by eating enough folate or folic acid. However, folate prevents only about 70 percent of these defects.
Folic acid to prevent congenital heart defects
The Canadian policy of fortifying grain products with folic acid has already proved to be effective in preventing neural tube defects.
Reducing Health Risks for Women and Children: American Dietetic Association Releases Position Paper on Obesity, Reproduction and Pregnancy Outcomes
Diet and nutrition counseling for virtually all overweight and obese women of childbearing age can reduce health risks associated with excess weight for mothers and children alike, according to a newly released position paper from the American Dietetic Association and the American Society of Nutrition.
Immigrant women may be at higher risk of having a baby with a birth defect
Immigrant women are less likely to use folic acid supplements before pregnancy to prevent spina bifida, particularly those who recently immigrated to the country, according to a new study led by a St. Michael's Hospital physician in collaboration with Statistics Canada, Health Canada and the University of Toronto.
Low levels of vitamin B12 may increase risk for neural tube defects
Children born to women who have low blood levels of vitamin B12 shortly before and after conception may have an increased risk of a neural tube defect, according to an analysis by researchers at the National Institutes of Health, Trinity College Dublin, and the Health Research Board of Ireland.
Scientists discover why teeth form in a single row
A system of opposing genetic forces determines why mammals develop a single row of teeth, while sharks sport several, according to a study published today in the journal Science. When completely understood, the genetic program described in the study may help guide efforts to re-grow missing teeth and prevent cleft palate, one of the most common birth defects.
Hairspray is linked to common genital birth defect, says study
Women who are exposed to hairspray in the workplace during pregnancy have more than double the risk of having a son with the genital birth defect hypospadias, according to a new study published today in the journal Environmental Health Perspectives.
SNPs affect folate metabolism in study of Puerto-Rican adults
Researchers at Tufts University have gained further understanding of the genomic basis for altered folate metabolism and the content of uracil in blood DNA.
More Neural Tube Defects Current Events and Neural Tube Defects News Articles
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Neural Tube Defects: From Origin to Treatment by Diego F. Wyszynski (Editor) Neural tube defects affect about 4000 pregnancies each year and are thus among the most common of severe birth defects. Prenatal diagnosis can now detect about 70% of neural tube defects but the tests produce many false positives, so the question is under what circumstances should they be recommended. This comprehensive volume - the collective knowledge of more than 55 experts in the field - provides lucid and authoritative discussions on this topic as well as on a wide variety of theoretical, experimental, and clinical issues. |
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Thorne Research 5-MTHF (5-Methyltetrahydrofolate) 60 Capsules by Thorne Research 5-MTHF is the most biologically active form of the B-vitamin folic acid. 5MTHF works in concert with vitamin B12 (methylcobalamin) in the conversion of homocysteine to methionine, which provides methyl groups for numerous other biochemical reactions in the body. Because of this, folate supplementation supports cardiovascular health, nervous system function, normal cellular proliferation, and gingival health. Folate supplementation during pregnancy has been shown to reduce the risk of neural tube defects. Research has shown a subset of individuals do not efficiently convert folic acid from their diet or supplements to active 5-MTHF, due to genetic enzyme deficiencies. Research suggests 5-MTHF is a more efficient form of supplementation than inactive folic acid in these and other... |
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AFP testing deemed expensive, obsolete.(Women's Health)(alpha fetoprotein): An article from: Family Practice News by Damian McNamara (Author) This digital document is an article from Family Practice News, published by Thomson Gale on April 1, 2006. The length of the article is 466 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: AFP testing deemed expensive, obsolete.(Women's Health)(alpha fetoprotein) Author: Damian McNamara Publication: Family Practice News (Magazine/Journal) Date: April 1, 2006 Publisher: Thomson Gale Volume: 36 Issue: 7 Page: 37(1) Distributed by Thomson... | |
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Neural Tube Defects Awareness Ribbon Mouse Pad by MyHeritageWear.com The Neural Tube Defects Ribbon proudly displayed on a mouse pad. There is no better way to achieve awareness for the meaning of the Neural Tube Defects Ribbon than to display it on your mouse pad for everyone to see. The mouse pad measures at 9.25 x 7.75, it is machine washable, and the colors will not fade or run. Start gaining awareness today by presenting your Neural Tube Defects Ribbon mouse pad at work or at home. It is certain to keep your mouse rolling in style all while gaining support and awareness! |
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Improving Child and Family Health through Primary Prevention of Neural Tube Defects.: An article from: Pediatric Nursing by Alison W. Schultz (Author) This digital document is an article from Pediatric Nursing, published by Jannetti Publications, Inc. on July 1, 1999. The length of the article is 3278 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. From the author: The neural tube defect, myelomeningocele, is the most complex congenital anomaly that is compatible with normal life, if appropriately treated. Knowledge of evidence-based primary prevention strategies for neural tube defects prevents the greatest number of these conditions from occurring. Primary prevention is key to family health. Only through primary prevention can the following be... | |
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Transitional and health issues of adults with neural tube defects.(Clinical Scholarship): An article from: Journal of Nursing Scholarship by Wendy M. Nehring (Author), Sandra A. Faux (Author) This digital document is an article from Journal of Nursing Scholarship, published by Thomson Gale on March 22, 2006. The length of the article is 6620 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Transitional and health issues of adults with neural tube defects.(Clinical Scholarship) Author: Wendy M. Nehring Publication: Journal of Nursing Scholarship (Magazine/Journal) Date: March 22, 2006 Publisher: Thomson Gale Volume: 38 Issue: 1 Page: 63(8) Distributed by Thomson... | |
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21st Century Complete Medical Guide to Spina Bifida and Related Neural Tube Defects: Authoritative Government Documents, Clinical References, and Practical ... for Patients and Physicians (CD-ROM) by PM Medical Health News (Author) This up-to-date electronic book on CD-ROM provides the best collection available anywhere of official Federal government information and documents on the subject of spina bifida. This CD-ROM uses next-generation search technology that allows complete indexing and makes all files on the disc fully searchable. For patients, practical information is provided in clearly written patient education documents. For medical professionals, doctor reference tools and texts have detailed technical information and clinical background material. This thoroughly researched collection presents vital information from many authoritative sources: National Institutes of Health (NIH), the Combined Health Information Database (CHID), Centers for Disease Control (CDC), the Food and Drug Administration... |
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Folic Acid for the Prevention of Neural Tube Defects by Gideon (editor) Koren (Author) | |
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Exposure to fumonisins and the occurrence of neural tube defects along the Texas-Mexico border.(Research): An article from: Environmental Health Perspectives by Stacey A. Missmer (Author), Lucina Suarez (Author), Marilyn Felkner (Author), Elaine Wang (Author), Alfred H., Jr. Merrill (Author), Kenneth J. Rothman (Author), Katherine A. Hendricks (Author) This digital document is an article from Environmental Health Perspectives, published by Thomson Gale on February 1, 2006. The length of the article is 6055 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Exposure to fumonisins and the occurrence of neural tube defects along the Texas-Mexico border.(Research) Author: Stacey A. Missmer Publication: Environmental Health Perspectives (Magazine/Journal) Date: February 1, 2006 Publisher: Thomson Gale Volume: 114 Issue: 2 Page: 237(5) Distributed by Thomson... | |
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Mortality and Maldevelopment: Part II: The Saga of Neural Tube Defects by Harold Kalter (Author) Congenital malformations are worldwide occurrences striking in every condition of society. These severe physical abnormalities which are present at birth and affecting every part of the body happen more often than usually realized, once in every 33 births. The most common, after heart defects, are those of the neural tube (the brain and spinal cord) which happen in as many as one in every 350 births. They have been noted as curiousities in man and beast throughout recorded history and received great attention in our time by various fields of study, for example, their faulty prenatal development by embryologists, familial patterns by geneticists, causation by environmentalists and variability by population scientists. Attention turned much in recent years to the relation of these... |
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