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Journal of Alzheimer's Disease is devoted to metal ions and neurodegenerative diseases
January 13, 2006Volume 8, Issue 2
The human body contains many metals, from the iron in hemoglobin to the calcium in bones. Other metals, usually in trace amounts, participate in many metabolic and degenerative processes. The recent issue of the Journal of Alzheimer's Disease (Volume 8, Issue 2) published by IOS Press is devoted to "Metal Ions and Neurodegenerative Diseases" and presents a collection of important papers dedicated to uncovering the role of various metals in human neurophysiology and neurodegenerative disorders, particularly Alzheimer's Disease.
Guest editor Paolo Zatta, CNR-Institute for Biomedical Technologies, Metalloproteins Unit, Department of Biology, University of Padova, Italy, sets the stage for the special issue. "Metal ions are essential building blocks for life. However, they are also deeply implicated in pathological events related to their depletion or abnormal accumulation in human and animal tissues, mainly the brain, with consequent neurodegenerative phenomena," he writes in the foreword, dedicated to Professor Marino Nicolini. "In the last three decades abundant scientific literature has attributed an important role to metal ions in neurodegenerative disorders such as Alzheimer's (AD), Parkinson's, Huntingtons's, Menkes' and Wilson's diseases, as well as amyotrophic lateral sclerosis, prion diseases and others."
The issue contains 11 research and review papers, a conference report from the 3rd International Conference on Metals and the Brain and the transcript of a live discussion among leading researchers in the field.
With papers covering iron and aluminum metabolism, zinc biochemistry, calcium and copper disorders, and other metal-related pathologies, this special issue provides key insights into the neurological effects of metals in the human body.
Case Western Reserve University
With papers covering iron and aluminum metabolism, zinc biochemistry, calcium and copper disorders, and other metal-related pathologies, this special issue provides key insights into the neurological effects of metals in the human body.
Case Western Reserve University
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Cognitive dysfunction reversed in mouse model of Down syndrome
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Researchers find potential treatment for Huntington's disease
Investigators at Burnham Institute for Medical Research (Burnham), the University of British Columbia's Centre for Molecular Medicine and Therapeutics and the University of California, San Diego have found that normal synaptic activity in nerve cells (the electrical activity in the brain that allows nerve cells to communicate with one another) protects the brain from the misfolded proteins associated with Huntington's disease.
Inhibitor of heat shock protein is a potential anticancer drug, Penn study finds
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Trembling hands and molecular handshakes
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Scientists remove amyloid plaques from brains of live animals with Alzheimer's disease
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Study supports possible role of urate in slowing Parkinson's disease progression
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Amyotrophic lateral sclerosis may involve a form of sudden, rapid aging of the immune system
Premature aging of the immune system appears to play a role in the development of amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease, according to research scientists from the Maxine Dunitz Neurosurgical Institute at Cedars-Sinai Medical Center, the Weizmann Institute of Science in Israel, and Sheba Medical Center in Israel.
Prion study reveals first direct information about the protein's molecular structure
A collaboration between scientists at Vanderbilt University and the University of California, San Francisco has led to the first direct information about the molecular structure of prions.
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