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WT1, male fertility and tumorigenesis
January 16, 2006Detailed in an upcoming report in G&D, Dr. Miles Wilkinson and colleagues use a new tissue-specific RNAi approach they developed to identify a novel postnatal role for the Wilms' tumor 1 (WT1) tumor suppressor in spermatogenesis. In a powerful example of the utility of their in vivo RNAi technology, the authors knock-down expression of WT1 specifically in Sertoli nurse cells in vivo. In conjunction with similar results the researchers obtained from dominant negative WT1 experiments, the authors conclude that the WT1 tumor suppressor drives spermatogenesis in the adult male. The authors' RNAi approach has the potential to delineate the tissue-specific function of virtually any gene in the mouse genome. Dr. Wilkinson emphasizes that this method could potentially be used in humans "to knockdown the expression of mutant or overexpressed genes that cause human diseases, including cancer."
Cold Spring Harbor Laboratory
Tumorigenesis Current Events and Tumorigenesis News RSSUCSF scientists illuminate how microRNAs drive tumor progression
UCSF researchers have identified collections of tiny molecules known as microRNAs that affect distinct processes critical for the progression of cancer.
Roles of S100A2 and p63 in the carcinogenesis of esophageal squamous cell carcinoma
As a member of the S100 family, S100A2 is considered a candidate tumor-suppressor gene. Recently, p63 gene, a new member of the p53 gene family, has been studied in the fields of tumorigenesis, cell apoptosis and tissue growth.
Genetic finding could lead to targeted therapy for neuroblastoma
Researchers have identified a genetic glitch that could lead to development of neuroblastoma, a deadly form of cancer that typically strikes children under 2.
Vaporized viral vector shows promise in anti-cancer gene therapy
A new lung cancer therapy employing a vaporized viral vector to deliver a cancer-inhibiting molecule directly to lung tissue shows early promise in mouse trials, according to researchers at the Ministry of Education, Science and Technology in Korea.
A potential anti-ulcer herb medicine: Rocket 'Eruca sativa'
Gastric ulcer is an illness that affects a considerable number of people worldwide. Although the introduction of proton-pump inhibitors to the classic anti-ulcer therapy has revolutionized treatment of peptic ulcers and other gastrointestinal disorders, there is still no complete cure for this disease.
A potential therapeutic target for gastric cancer
Gastric cancer (GC) is the fourth most common malignancy and the second most frequent cause of cancer-related death in the world.
May supplementation of docosahexaenoic acid suppress colon tumor cell growth?
Colon cancer is one of the leading causes of death in Western countries. The role of n-3 and n-6 PUFAs in colorectal carcinoma cell growth has not been well studied. It is known that PGE2, generated from AA, is an important factor in the tumorigenesis of colorectal cancer.
What's the role of beta-catenin in colorectal cancers?
Beta-catenin, a central molecule of the Wnt-signaling pathway was previously known to involve in the tumorigenesis of various gastrointestinal cancers such as gastric cancer and colon cancer.
Purple tomatoes: The richness of antioxidants against tumors
Researchers from the John Innes Centre in Norwich, Great Britain, in collaboration with other European centres participating to the FLORA project, have obtained genetically modified tomatoes rich in anthocyanins, a category of antioxidants belonging to the class of flavonoids.
Novel marker of colon cancer
Colon cancer ranks second of all gastrointestinal malignant tumors, it is one of the leading causes of cancer-related deaths worldwide.
More Tumorigenesis Current Events and Tumorigenesis News Articles
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Rb and Tumorigenesis (Medical Intelligence Unit) by Maurizio Fanciulli (Editor) Rb and Tumorigenesis examines how recent advances have demonstrated the interaction of Rb with chromatin remodeling enzymes. This new title explores the potential roles of these interactions in Rb functions and provides some evidence that distinct Rb co-repressor may target different genes in different phases of the cell cycle. |
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Mechanisms of Oncogenesis: An update on Tumorigenesis (Cancer Growth and Progression) by Domenico Coppola (Editor) This volume is part of a book series that was first published in 10-volumes by Kluwer in 1989 under the series editorship of Professor Hans E. Kaiser, D.Sc., former Professor of Pathology at the School of Medicine, University of Maryland at Baltimore, MD, USA along with other leaders in the field of Cancer. In order to encompass the growing body of knowledge on various aspects of cancer growth and progression since then, the series has now been expanded to 17 volumes. This volume is a comprehensive update on the mechanisms of tumorigenesis, and includes the advances in the field, as provided by the use of the most recent molecular techniques (microarray, proteomic, and other omics). While the first portion of the book contains chapters discussing pediatric cancer, the... | |
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Key issues in the modes of action and effects of trichloroethylene metabolites for liver and kidney tumorigenesis.(Mini-Monograph): An article from: Environmental Health Perspectives by Jane C. Caldwell (Author), Nagalakshmi Keshava (Author) This digital document is an article from Environmental Health Perspectives, published by Thomson Gale on September 1, 2006. The length of the article is 8918 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Key issues in the modes of action and effects of trichloroethylene metabolites for liver and kidney tumorigenesis.(Mini-Monograph) Author: Jane C. Caldwell Publication: Environmental Health Perspectives (Magazine/Journal) Date: September 1, 2006 Publisher: Thomson Gale Volume: 114 Issue: 9 Page: 1457(7) Distributed by Thomson... | |
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Genetics in Growth, and Pituitary Tumorigenesis: 10th Kigs/Kims Expert Meeting on Growth Hormone and Growth Disorders, Florence, April 2008 Supplement Issue: Hormone Research 2009 by D. B. Dunger (Editor), V. Popovic-brkic (Editor) |
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Mammary Tumorigenesis and Malignant Progression: Advances in Cellular and Molecular Biology of Breast Cancer (Cancer Treatment and Research) by Robert B. Dickson (Editor), Marc E. Lippman (Editor) The current volume represents the fourth over a period of five years in the series on advances in the cellular and molecular biology of breast cancer. Throughout this series, a broad view has been taken at what are cutting edge topics in the basic research into breast cancer. Since the last volume, research in breast cancer has continued to proceed at an explosive rate, and the current volume will provide the reader with some of the excitement felt by the editors and authors. The first section is devoted to the basic process of proliferation, differentiation, and malignant progression of breast cancer. The second section emphasizes the genetic basis for breast cancer onset and malignant progression. The third section deals with growth factors, receptors, and polyamines in... | |
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ADRENALS CONTRA TUMORIGENESIS: ADRENALS AROUND CARCINOGEN CONTAINING IMPLANTS SUPPRESS TUMORIGENESIS by Ingrid Mesila (Author) Cancerogenesis and influencing of this process is an actual field of research in the world. Tumorigenesis is still of interest in every time and will be. The book may have importance among several anti carcinoma genesis findings. We used a new model of experimental cancerogenesis by using well known 7,12-dimethylbenz(a)anthracene (DMBA). The main goal of the work was to study effects of biological tissue on the development of tumours and variation of reactive changes in DMBA-containing implants and surrounding tissue, accompanying changes in mitotic activity in intact organs. We found that adrenals as biological material protect from the tumour. This finding could be explained with the stronger immune reaction, induced by biological material but this may be associated with... |
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Dietary Fats, Lipids, Hormones and Tumorigenesis (Advances in Experimental Medicine and Biology) by David Heber (Editor), David Kritchevsky (Editor) University of California, Los Angeles. Proceedings from the Nutrition and Cancer Prevention Scientific Symposium sponsored by the UCLA/NCI Clinical Nutrition Unit, held November 14, 1994, in Los Angeles. 19 U.S. contributors. |
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Virus Tumorigenesis and Immunogenesis by W.S. Ceglowski (Editor), etc. (Editor) | |
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Pdgf in Cerebellar Development & Tumorigenesis (Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, 1018) by Johanna Andrae (Author) | |
![Role of nucleotide excision repair deficiency in intestinal tumorigenesis in multiple intestinal neoplasia (Min) mice [An article from: Mut.Res.-Genetic Toxicology and Environmental Mutagenesis]](http://ecx.images-amazon.com/images/I/51VRJGWFK9L._SL160_.jpg) |
Role of nucleotide excision repair deficiency in intestinal tumorigenesis in multiple intestinal neoplasia (Min) mice [An article from: Mut.Res.-Genetic Toxicology and Environmental Mutagenesis] by I.L. Steffensen (Author), H.A.J. Schut (Author), J.M. Nesland (Author), Tanak (Author) This digital document is a journal article from Mut.Res.-Genetic Toxicology and Environmental Mutagenesis, published by Elsevier in 2006. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser. Description: Mice deficient in the Xeroderma pigmentosum group A (Xpa) gene are defective in nucleotide excision repair (NER) and highly susceptible to skin carcinogenesis after dermal exposure to UV light or chemicals. Min (multiple intestinal neoplasia) mice, heterozygous for a germline nonsense mutation in the tumor suppressor gene adenomatous polyposis coli (Apc), develop intestinal tumors spontaneously and show additional intestinal tumors after exposure to the food mutagen... |
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