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Improved diagnostic technology for Crohn's disease
January 31, 2006The diagnostic value of CT enteroclysis is superior to conventional enteroclysis, previously considered the gold standard, as an imaging method for the evaluation of the small bowel in patients with Crohn's disease, a new study shows.
Crohn's disease is an inflammatory disease of the intestinal wall. Complications of Crohn's disease, such as abscesses, and stenoses, are found in approximately 40% of patients. Patients with inflammatory and some-times even obstructive small-bowel disease require prompt and accurate treatment to relieve their symptoms and to minimize the risk of potential complications.
"CT enteroclysis and conventional enteroclysis were successfully performed in all 50 patients (100%), however significantly more Crohn's disease-associated abnormalities were diagnosed with CT enteroclysis than with conventional enteroclysis," said the authors of the study.
"The big advantage of CT enteroclysis is its ability to detect complications which exist outside normal parameters of the diagnosis and identification of Crohn's disease," said Johannes Sailer, MD, lead author of the study. "Our recent study proved that CT enteroclysis can detect fistula, abscess and conglomeration tumor superior to conventional enteroclysis, with no disadvantages in the detection of minimal mucosal changes (a sign of early stage Crohn's disease)."
"CT enteroclysis can also be performed in follow up examinations of patients," said Dr. Sailer. "These results can help the clinicians in adapting their treatment and in deciding whether a surgical resection is needed."
"CT enteroclysis is an excellent technique for diagnosis of all small bowel diseases, which show morphologic changes to the bowel wall," said Dr. Sailer. "We use it for detection of bowel wall pathologies such as tumors and inflammatory changes, especially in patients with inflammatory bowel disease, as well as for the diagnosis of lymphoma and other intestinal tumors. In our department it is already a standard procedure."
"CT enteroclysis is the imaging method of choice and should replace conventional enteroclysis in patients with Crohn's disease," said the authors of the study.
American Roentgen Ray Society
"The big advantage of CT enteroclysis is its ability to detect complications which exist outside normal parameters of the diagnosis and identification of Crohn's disease," said Johannes Sailer, MD, lead author of the study. "Our recent study proved that CT enteroclysis can detect fistula, abscess and conglomeration tumor superior to conventional enteroclysis, with no disadvantages in the detection of minimal mucosal changes (a sign of early stage Crohn's disease)."
"CT enteroclysis can also be performed in follow up examinations of patients," said Dr. Sailer. "These results can help the clinicians in adapting their treatment and in deciding whether a surgical resection is needed."
"CT enteroclysis is an excellent technique for diagnosis of all small bowel diseases, which show morphologic changes to the bowel wall," said Dr. Sailer. "We use it for detection of bowel wall pathologies such as tumors and inflammatory changes, especially in patients with inflammatory bowel disease, as well as for the diagnosis of lymphoma and other intestinal tumors. In our department it is already a standard procedure."
"CT enteroclysis is the imaging method of choice and should replace conventional enteroclysis in patients with Crohn's disease," said the authors of the study.
American Roentgen Ray Society
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Left handers at twice the risk of inflammatory bowel disease
Left handers seem to be at twice the risk of developing inflammatory bowel disease, such as Crohn's disease and ulcerative colitis, suggests research in Gut. The research focused on two national groups of people born in 1958 and 1970 in Great Britain, who were monitored by questionnaire at the ages of 26 and 33. Handedness was determined from hand preference for writing and foot preference for kicking a ball at the age of either 7 or 10. In total, around 17,000 people were included in the study. Significantly more men than women were left handers, but gender was not itself associated with increased risk of inflammatory bowel disease (IBD). But later birth was, with those born in 1970 more li
SPECIFIC GENE MUTATION LINKED TO CROHN'S DISEASE (pp 1902, 1925)
Genetic susceptibility to Crohn's disease is likely to be the result of an insertion mutation into a specific gene on chromosome 16, conclude authors of a fast-track study published in this week's issue of THE LANCET. In 1996, genetic linkage of inflammatory bowel disease (IBD) to chromosome 16 was established. The recently identified NOD2 gene is a possible candidate since it is located in the region of linkage on chromosome 16q12, and activates nuclear factor (NF) κB in response to bacterial lipopolysaccharides. Stefan Schreiber and colleagues from Kiel University, Germany, sequenced the coding region of the NOD2 gene and genotyped an insertion polymorphism (alteration) in 512 indivi
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