 |
|
Omega-6 fats cause prostate tumors to grow twice as fast
February 01, 2006Fatty acids such as those found in corn oil turn on genes that stimulate tumor growth
Omega-6 fatty acids-such as those found in corn oil-caused human prostate tumors in cell culture to grow twice as quickly as tumors to which omega-6 fats had not been added, according to a study conducted at the San Francisco VA Medical Center.
An omega-6 fatty acid known as arachidonic acid turns on a gene signaling pathway that leads directly to tumor growth, according to principal investigator Millie Hughes-Fulford, PhD, director of the Laboratory of Cell Growth at SFVAMC and scientific advisor to the U.S. Under Secretary for Health for the Department of Veterans Affairs.
The results of the study are published in the February 1 issue of Cancer Research.
"After we added omega-6 fatty acids to the growth medium in the dish, and only omega-6, we observed that tumors grew twice as fast as those without omega-6," recounts Hughes-Fulford, who is also an adjunct professor of medicine at the University of California, San Francisco.
"Investigating the reasons for this rapid growth, we discovered that the omega-6 was turning on a dozen inflammatory genes that are known to be important in cancer. We then asked what was turning on those genes, and found that omega-6 fatty acids actually turn on a signal pathway called PI3-kinase that is known to be a key player in cancer," she adds.
Hughes-Fulford says the results are significant because of the high level of omega-6 fatty acids in the modern American diet, mostly in the form of vegetable seed oils such as corn oil-over 25 times the level of beneficial omega-3 fatty acids, which are found in canola oil, fish, and green vegetables. She notes that over the last 60 years, the rate of prostate cancer in the U.S. has increased steadily along with intake of omega-6, suggesting a possible link between diet and prostate cancer.
The study results build on earlier work in which Fulford and her research team found that arachidonic acid stimulated the production of an enzyme known as cPLA-2, which in turn caused a chain of biochemical reactions that led to tumor growth. In the current paper, the researchers have "followed that biochemical cascade upstream to its source," Hughes-Fulford says. "These fatty acids are initiating the signal pathway that begins the whole cascade."
Hughes-Fulford and her fellow researchers also found that if they added a non-steroidal antiflammatory or a PI3K inhibitor to the growth media, interrupting the signal pathway, the genes did not get turned on and increased tumor cell growth did not take place.
Currently, Hughes-Fulford is conducting a study in which research animals are fed diets with different levels of omega-3 and omega-6 fatty acids, "to see how the tumors grow in animals."
Hughes-Fulford says that her study results have directly influenced her own diet. "I'm not a physician, and do not tell people how to eat, but I can tell you what I do in my own home," she says. "I use only canola oil and olive oil. We do not eat deep-fried foods."
University of California-San Francisco
The results of the study are published in the February 1 issue of Cancer Research.
"After we added omega-6 fatty acids to the growth medium in the dish, and only omega-6, we observed that tumors grew twice as fast as those without omega-6," recounts Hughes-Fulford, who is also an adjunct professor of medicine at the University of California, San Francisco.
"Investigating the reasons for this rapid growth, we discovered that the omega-6 was turning on a dozen inflammatory genes that are known to be important in cancer. We then asked what was turning on those genes, and found that omega-6 fatty acids actually turn on a signal pathway called PI3-kinase that is known to be a key player in cancer," she adds.
Hughes-Fulford says the results are significant because of the high level of omega-6 fatty acids in the modern American diet, mostly in the form of vegetable seed oils such as corn oil-over 25 times the level of beneficial omega-3 fatty acids, which are found in canola oil, fish, and green vegetables. She notes that over the last 60 years, the rate of prostate cancer in the U.S. has increased steadily along with intake of omega-6, suggesting a possible link between diet and prostate cancer.
The study results build on earlier work in which Fulford and her research team found that arachidonic acid stimulated the production of an enzyme known as cPLA-2, which in turn caused a chain of biochemical reactions that led to tumor growth. In the current paper, the researchers have "followed that biochemical cascade upstream to its source," Hughes-Fulford says. "These fatty acids are initiating the signal pathway that begins the whole cascade."
Hughes-Fulford and her fellow researchers also found that if they added a non-steroidal antiflammatory or a PI3K inhibitor to the growth media, interrupting the signal pathway, the genes did not get turned on and increased tumor cell growth did not take place.
Currently, Hughes-Fulford is conducting a study in which research animals are fed diets with different levels of omega-3 and omega-6 fatty acids, "to see how the tumors grow in animals."
Hughes-Fulford says that her study results have directly influenced her own diet. "I'm not a physician, and do not tell people how to eat, but I can tell you what I do in my own home," she says. "I use only canola oil and olive oil. We do not eat deep-fried foods."
University of California-San Francisco
Omega-6 Fatty Acids Current Events and Omega-6 Fatty Acids News RSSOmega fatty acid balance can alter immunity and gene expression
For the past century, changes in the Western diet have altered the consumption of omega-6 fatty acids (w6, found in meat and vegetable oils) compared with omega-3 fatty acids (w3, found in flax and fish oil).
Organic milk is cream of the crop
A new study by Newcastle University proves that organic farmers who let their cows graze as nature intended are producing better quality milk.
Reducing intake of dietary fat prevents prostate cancer in mice
Scientists with UCLA's Jonsson Cancer Center and the Department of Urology have showed that lowering intake of the type of fat common in a Western diet helps prevent prostate cancer in mice, the first finding of its kind in a mouse model that closely mimics human cancer, researchers said.
Omega-3 fatty acids protect eyes against retinopathy, study finds
Omega-3 polyunsaturated fatty acids protect against the development and progression of retinopathy, a deterioration of the retina, in mice.
Genes and diet linked to risk factors for heart disease
Researchers from the Jean Mayer USDA Human Nutrition Research Center (USDA HNRCA) at Tufts University and colleagues have found another link among genes, heart disease and diet.
UCLA study shows altering fatty acid levels in diet may reduce prostate cancer growth rate
UCLA researchers found that altering the fatty acid ratio found in the typical Western diet to include more omega-3 fatty acids and decrease the amount of omega-6 fatty acids may reduce prostate cancer tumor growth rates and PSA levels.
The right kind of oil
Children who cannot eat on their own because of intestinal failure must rely on parenteral nutrition (PN), an intravenous method of feeding.
Avoiding house dust mites and changing diet proves ineffective
New research shows avoiding house dust mite allergens from birth does not prevent the onset of asthma, eczema or atopy in high-risk children.
Omega-3 fatty acids inhibit growth of liver cancer cells
Two new studies by a University of Pittsburgh research team suggest that omega-3 fatty acids-substances that are found in high concentrations in fish oils and certain seeds and nuts-significantly inhibit the growth of liver cancer cells.
Researchers create pigs that produce heart-healthy omega-3 fatty acids
Researchers report they have created pigs that produce omega-3 fatty acids, which are known to improve heart function and help reduce the risks for heart disease, representing the first cloned transgenic livestock in the world that can make the beneficial compound.
More Omega-6 Fatty Acids Current Events and Omega-6 Fatty Acids News Articles
 |
Source Naturals Essential Fatty Acids (Complete), 120 softgels by Source Naturals Dietary supplement. Source Naturals Complete Essential Fatty Acids is an excellent blend of omega-3 and omega-6 fatty acids. Docosahexaenoic Acid (DHA) is an omega-3 fatty acid which plays a significant role in cerebral development throughout the life style, especially during the crucial period of fetal development and infancy. Gamma-Linolenic Acid (GLA) is an omega-6 fatty acid used by most cells in the body to produce soothing PGE1 prostaglandins. Essential Fatty Acids, or EFA's, act as precursors to molecules such as prostaglandins, thromboxanes and leukotrienes, which help regulate cellular function. EFA's have been shown to play a role in blood pressure maintenance, immune system balance, sustaining healthy skin, and providing nutritional support during women's cycles (These... |
 |
Kirkland Signature Fish Oil w/ Omega-3 Fatty Acids - One Per Day Formula - 180 Enteric Coated Softgels by Omega 3 Fatty Acids The enteric coating reduces the fishy odor and aftertaste by protecting the softgel until it reaches the lower intestine. Kirkland Signature fish supply comes from deep ocean waters. Our fish oil is not supplied from farm-raised fish. State-of-the-art molecular distillation process is used to remove mercury, PCBs and dioxins which guarantees purity and potency. Fish Oil naturally contains the Omega3 Fatty Acids, EPA and DHA. Omega-3 Fatty Acids help maintain heart and vascular health.* *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. |
|
Omega-6 fatty acids: An entry from Thomson Gale's Gale Encyclopedia of Alternative Medicine by Judith Sims (Author) The term “Alternative Medicine” encompasses many forms, and elicits at least as many opinions. This authoritative, objective set is in tune with the subjects that matter to students and researchers, presenting four volumes of current, unbiased information on alternative and complementary medical practices. Covering all aspects of the subject—Therapies, Conditions/Diseases, Herbs/Plants and People—the “Gale Encyclopedia of Alternative Medicine” identifies 150 types of alternative medicine being practiced today, including reflexology, acupressure, acupuncture, chelation therapy, kinesiology, yoga, chiropractic, Feldenkrais, polarity therapy, detoxification, naturopathy, Chinese medicine, biofeedback, Ayurveda and osteopathy. For the practitioner or interested patient, there... | |
 |
Nutri-Vet Shed Defense Liver Flavored Soft Chews with Omega 3 and 6 Fatty Acids, 5.3 Ounce Bag by nutri-vet Nutri-Vet Shed Defense Soft Chews contain Omega-3 and -6 fatty acids from fish oil that help dogs achieve a soft, silky and shiny coat as well as reduce unwanted shedding. Shed Defense soft chews are an easy way to reward your dog with a tasty treat and a healthy coat. |
 |
All-Natural Country Chicken, 6 Whole Frozen Chickens by Wisconsinmade.com All-Natural Country Chicken is gourmet poultry raised the old-fashioned way on small family Amish farms in southwest Wisconsin. Select 2, 4, or 6 whole All-Natural Country frozen chickens from Hillsboro Meats and taste the difference that all-natural, free-range chickens offer. Each bird will average 4.5 lbs. including giblets. Our All-Natural Chicken is perfect for an everyday dinner as well as a special occasion meal. Hillsboro Meats, LLC raises European Heritage Breeds of chickens. These birds are sustainably and humanely raised on small family Amish farms providing a minimum of 6 acres of pasture and woodland for feeding. The chickens are never caged; free of antibiotics, hormones, and additives; and provided an all-natural vegetarian diet that supplements the food they forage... |
 |
Udo's Choice Oil 3-6-9 Blend 180 Capsules by Udo's Choice Udo’S Oil 369 Blend Contains The Ideal Balance Of Omega-3 And -6 Essential Fatty Acids (2:1) For People Who Want One Product That Gives Them All Of The Good Fats They Need, Without Any Of The Bad Fats They Should Avoid. Every Cell, Tissue, Gland And Organ Is Dependent Upon The Presence Of Essential Fatty Acids. They Are The Main Structural Component Of Cell Membranes And Are Necessary For Cell Growth And Division. Udo's Oil Is Formulated By Udo Erasmus, Phd, An Internationally Acclaimed Authority On The Subject Of Essential Fatty Acids And Author Of The Groundbreaking Book Fats That Heal Fats That Kill. Udo's Oil Blend Is Fresh-Pressed In A State-Of-Theart Low Heat, Light And Oxygen-Free Environment And Packaged In An Environmentally Friendly Glass Bottle. Udo’S Oil Has A Pleasant,... |
 |
Vitalogic EFA Formula with Omega 3, 6 & 9, Fatty Acids - 180 Softgels by VitaLogic EFA Formula by VitaLogic - 180 Softgels |
|
Recommendations for dietary omega-6 fatty acids released: you probably eat enough already, but you don't want to consume too much.(NUTRITION): An article from: Heart Advisor by Unavailable (Author) This digital document is an article from Heart Advisor, published by Belvoir Media Group, LLC on July 1, 2009. The length of the article is 406 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available immediately after purchase. You can view it with any web browser. Citation Details Title: Recommendations for dietary omega-6 fatty acids released: you probably eat enough already, but you don't want to consume too much.(NUTRITION) Author: Unavailable Publication: Heart Advisor (Magazine/Journal) Date: July 1, 2009 Publisher: Belvoir Media Group, LLC Volume: 12 Issue: 7 Page: NA Distributed by Gale, a part of Cengage... | |
 |
Omega 3, 6, 9 - 90 Gel Caps by VETRI-SCIENCE LABS A heart, skin and coat supplement for Cats and Dogs. Omega 3, 6, 9 provides a healthy balance of essential fatty acids that are critical to total body health. These fatty acids play a vital role in the structure of cell membranes, help to maintain healthy skin and coat, support the immune system and promote proper growth and development of the nervous system. Cats cannot convert LA to GLA because their liver lacks the enzyme required for this conversion. Daily supplementation with HLA, ALA, SPA and DHA is the best way to ensure that the cat or dog receives usable essential fatty acids. Directions for gelcaps: Cats: 1 gelcap every other day. Dogs: Under 15 pounds - 1 gelcap ever other day, 15 to 30 pounds - 1 gelcap daily, over 30 pounds - 1 gelcap per 30 pounds. |
 |
Bija Dark Chocolate Omega Truffle Bars (Pack Of 12) by Bija Flora's Luxurious Bija Omega Truffles Are A Rich Blend Of Premium Organic Ingredients And Essential Fatty Acids. Each Package Contains A Full Serving Of Udo's 369 Oil Blend Providing 13 Grams Of Omega-3, 6 And 9. There Is Increasing Evidence That Chocolate Contains Surprising Amounts Of Minerals, Potent Anti-Oxidants And Other Phytonutrients. In The World Of Chocolate, Bija Omega Truffles Are The Best Of The Best. We Have Sought Out And Selected The Highest Quality Organic Ingredients From Around The World: Chocolate And Cocoa Butter From Peru, Madagascar Vanilla Beans, Hazelnuts From British Columbia, Maple Sugar From Quebec, And Skim Milk Powder From Ontario - Just To Name A Few. Bija Has Enhanced This Organic Chocolate By Adding A Full Tablespoon (13 Grams) Of Udo's 369 Oil Blend To... |
| © 2009 BrightSurf.com |