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Metabolic acidosis associated with an increased mortality rate
February 10, 2006Critically ill patients with metabolic acidosis are twice as likely to die as patients who do not have metabolic acidosis. A study published today in the journal Critical Care shows that the mortality rate among patients with metabolic acidosis is highest for patients with lactic acidosis - abnormally acidic blood pH due to an excess of lactate-but it is also considerable for patients with strong ion gap (SIG) acidosis - acidosis due to an excess of unidentified ions. Both lactate and SIG should be carefully monitored in intensive care units (ICUs).
In the largest study of its kind, Kyle Gunnerson from Virginia Commonwealth University, Virginia, USA and colleagues from the University of Pittsburgh, Pennsylvania, USA, selected patients admitted to the University of Pittsburgh Medical Center ICUs who were suspected of having metabolic acidosis. Out of 851 patients screened, 548 patients had metabolic acidosis and 303 patients did not. The patients who did not were used as the control, non-acidosis group.
Among patients with metabolic acidosis, 44% of patients had lactic acidosis, 37% of patients had SIG acidosis and 19% had hyperchloremic acidosis (acidosis not associated with either lactate or SIG). The mortality rate was 45% for patients with metabolic acidosis compared with 26% for patients without. Patients with lactic acidosis had a mortality rate of 56% and for patients with SIG acidosis, the mortality rate was 39%. Patients with hyperchloremic acidosis had a mortality rate similar to the rate in the non-acidosis group: 29%.
A statistical analysis confirmed that both lactate and SIG were strong independent predictors of hospital mortality. The authors recommend that both should be monitored in critically ill patients.
BioMed Central
A statistical analysis confirmed that both lactate and SIG were strong independent predictors of hospital mortality. The authors recommend that both should be monitored in critically ill patients.
BioMed Central
Gene may 'bypass' disease-linked mitochondrial defects, fly study suggests
By lending them a gene normally reserved for other classes of animals, researchers have shown they can rescue flies from their Parkinson's-like symptoms, including movement defects and excess free radicals produced in power-generating cellular components called mitochondria.
Drug prescribed for migraines and seizures increases risk of kidney stones
Topiramate (Topamax), a drug commonly prescribed to treat seizures and migraine headaches, can increase the propensity of calcium phosphate kidney stones, researchers at UT Southwestern Medical Center have found.
Drug prescribed for migraines and seizures increases risk of kidney stones
Topiramate (Topamax), a drug commonly prescribed to treat seizures and migraine headaches, can increase the propensity of calcium phosphate kidney stones, researchers at UT Southwestern Medical Center have found.
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EKG & Critical Care Education Suite 2.0 by Mind-Forge Education Services LLC This suite contains four training modules: EKG, Heart Sounds, Lung Sounds, and Arterial Blood Gas. They are appropriate for all skill levels, whether you are a student learning this information for the first time or a long time nurse looking for a refresher. |
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Metabolic Acidosis - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References by ICON Health Publications (Author) In March 2001, the National Institutes of Health issued the following warning: "The number of Web sites offering health-related resources grows every day. Many sites provide valuable information, while others may have information that is unreliable or misleading." Furthermore, because of the rapid increase in Internet-based information, many hours can be wasted searching, selecting, and printing.This book was created for medical professionals, students, and members of the general public who want to conduct medical research using the most advanced tools available and spending the least amount of time doing so. |
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