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Drawing a crowd: How progenitor cells are recruited to tumor blood vessels from the bone marrow
February 24, 2006Cells within the bone marrow (progenitor cells) that express a protein called CD34 have been shown to leave the marrow and travel to sites of tissue injury to mediate repair. Once the cells arrive at the site of injury it has been demonstrated that they can turn into a variety of different cell types, including blood vessel cells, muscle cells, nerve cells, and blood cells, which enhances wound healing. However, the mechanisms responsible for recruiting these CD34-positive progenitor cells from the bone marrow and to the site of tissue damage are unclear. Now, in a study appearing online on February 23 in advance of print publication in the March issue of the Journal of Clinical Investigation, Judy Varner and colleagues from the University of California, San Diego show that a protein called alpha4-beta1 integrin (or VLA-4) promotes the homing of these progenitor cells to VLA-4-binding molecules called VCAM and fibronectin found on both actively healing and tumor-associated blood vessels. The researchers found that progenitor cells were drawn to sites of active blood vessel formation in tumors, but not to normal tissues, due to the presence of VLA-4 in the tumor vessels. In addition, the authors found that blocking VLA-4 with an antibody prevented the progenitor cells from sticking to blood vessels, from migrating to newly formed vessels, and from changing into different cell types. Together these studies support a potent role of VLA-4 in the regulation of bone marrow-derived progenitor cells in wound repair and migration. The authors suggest that inhibiting this homing process could be useful in suppressing new blood vessel formation in tumors.
Journal of Clinical Investigation
Progenitor Cells Current Events and Progenitor Cells News RSSStem cell therapy may offer hope for acute lung injury
Researchers at the University of Illinois at Chicago College of Medicine have shown that adult stem cells from bone marrow can prevent acute lung injury in a mouse model of the disease.
UNC study pinpoints gene controlling number of brain cells
In populating the growing brain, neural stem cells must strike a delicate balance between two key processes - proliferation, in which the cells multiply to provide plenty of starting materials - and differentiation, in which those materials evolve into functioning neurons.
New study finds way to stop excessive bone growth following trauma or surgery
A recent United States Army study found that excessive bone growth, also known as heterotopic ossificiation (HO), affects up to 70 percent of soldiers who are severely wounded during combat. A much smaller percentage of the civilian population also suffers from HO following trauma or invasive surgery.
Reactive oxygen in fruit flies acts as a cell signalling mechanism for immune response
For years, health conscious people have been taking antioxidants to reduce the levels of reactive oxygen in their blood and prevent the DNA damage done by free radicals, which are the result of oxidative stress. But could excessive use of antioxidants deplete our immune systems?
A consistent decline in heart attack rates following the implementation of smoking bans
Strongly enforced legislation to restrict smoking produces rapid and substantial reductions in community rates of heart attack, according to a meta-analysis published today in Circulation, the journal of the American Heart Association.
Turning back the clock: Fasting prolongs reproductive life span
Scientific dogma has long asserted that females are born with their entire lifetime's supply of eggs, and once they're gone, they're gone.
How to Make a Lung: Cell-Regeneration Molecules Essential Signals for Early Lung Development, Penn Study Finds
A tissue-repair-and-regeneration pathway in the human body, including wound healing, is essential for the early lung to develop properly.
Noninsulin-producing alpha cells in the pancreas can be converted to insulin-producing beta cells
In findings that add to the prospects of regenerating insulin-producing cells in people with type 1 diabetes, researchers in Europe -- co-funded by the Juvenile Diabetes Research Foundation -- have shown that insulin-producing beta cells can be derived from non-insulin-producing cells in the pancreas.
Stem cell 'daughters' lead to breast cancer
Walter and Eliza Hall Institute scientists have found that a population of breast cells called luminal progenitor cells are likely to be responsible for breast cancers that develop in women carrying mutations in the gene BRCA1.
Study shows cancer vaccines led to long-term survival for patients with metastatic melanoma
Hoag Memorial Hospital Presbyterian today announced promising data from a clinical study showing patient-specific cancer vaccines derived from patients' own cancer cells and immune cells were well tolerated and resulted in impressive long-term survival rates in patients with metastatic melanoma whose disease had been minimized by other therapies.
More Progenitor Cells Current Events and Progenitor Cells News Articles
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The Neuroendocrine Leydig Cells and their Stem Cell Progenitors, the Pericytes (Advances in Anatomy, Embryology and Cell Biology) by Michail S. Davidoff (Author), Ralf Middendorff (Author), D. Müller (Author), Adolf F. Holstein (Author) The discovery of the neuroendocrine features of Leydig cells gave rise to the hypothesis of a potential neuroectodermal and/or neural crest origin of testicular Leydig cells. In an experimental animal model the authors revealed that adult Leydig cells originate by transdifferentiation from stem/progenitor cells (pericytes and smooth muscle cells), underlying the close relationship of Leydig cells with testis microvasculature. This and the supporting data from the literature provided the basis for revealing the pericytes as a common adult stem cell type of mammalian species. Distributed by the microvasculature through the entire body, the pericyte, acting as a resting early pluripotent adult stem cell, provides an ingenious system to assure the maintenance, physiological repair and... |
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Recognizing Skin Signs of Systematic Disease/High-Dose Chemotherapy with Autologous Hematopoietic Progenitor Cell Support for the Treatment of Breast Cancer (NCME Video 689) Also With: Irwin W. Braverman (Primary Contributor), Elizabeth J. Shpall (Primary Contributor) |
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Identification and Characterization of Neural Progenitor Cells in the Adult Mammalian Brain (Advances in Anatomy, Embryology and Cell Biology) by Sara Gil-Perotín (Author), Arturo Alvarez-Buylla (Author), José Manuel García-Verdugo (Author) Adult neurogenesis has been questioned for many years. In the early 1900s, a dogma was established that denied new neuron formation in the adult brain. In the last century however, new discoveries have demonstrated the real existence of proliferation in the adult brain, and in the last decade, these studies led to the identification of neural stem cells in mammals. Adult neural stem cells are undifferentiated cells that are present in the adult brain and are capable of dividing and differentiating into glia and new neurons. Newly formed neurons terminally differentiate into mature neurons in the olfactory bulb and the dentate gyrus of the hippocampus. Since then, a number of new research lines have emerged whose common objective is the phenotypical and molecular characterization of... |
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Stem and Progenitor Cells in the Central Nervous System: Developmental Neuroscience 2004 No. 2-4 by R. S. Nowakowski (Author) |
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Hematopoietic Progenitor Cells: A Primer for Medical Professionals by Edward L. Snyder (Author), N. Rebecca Haley (Author) Yale Univ., New Haven, CT. Pocket guide to the biology of HPCs, including the basic science of these cells and their function. Discusses concepts of the HLA system regarding recognition of self vs non-self. Provides information on regulations and standards for hematopoietic progenitor cell facilities and discusses professional standards. Previous edition: c1995. Softcover. |
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Incara announces issuance of additional patent for isolating liver progenitor cells.(Brief Article): An article from: BIOTECH Patent News by Biotech Patent News (Publisher) This digital document is an article from BIOTECH Patent News, published by Biotech Patent News on June 1, 2001. The length of the article is 392 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Incara announces issuance of additional patent for isolating liver progenitor cells.(Brief Article) Publication: BIOTECH Patent News (Newsletter) Date: June 1, 2001 Publisher: Biotech Patent News Volume: 15 Issue: 6 Page: NA Article Type: Brief Article Distributed by Thomson... | |
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Isolation and Induction of Neuronal Progenitor Cells (Neurodegenerative Diseases 2007) by Arndt Rolfs (Editor) |
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Polychlorinated biphenyls disturb differentiation of normal human neural progenitor cells: clue for involvement of thyroid hormone receptors.(Research): ... from: Environmental Health Perspectives by Ellen Fritsche (Author), Jason E. Cline (Author), Ngoc-Ha Nguyen (Author), Thomas S. Scanlan (Author), Josef Abel (Author) This digital document is an article from Environmental Health Perspectives, published by National Institute of Environmental Health Sciences on July 1, 2005. The length of the article is 6994 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Polychlorinated biphenyls disturb differentiation of normal human neural progenitor cells: clue for involvement of thyroid hormone receptors.(Research) Author: Ellen Fritsche Publication: Environmental Health Perspectives (Magazine/Journal) Date: July 1, 2005 Publisher: National Institute of Environmental Health... | |
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Alternative to Embryonic Stem Cells.("multipotent adult progenitor cells" from bone marrow): An article from: National Right to Life News by Dave Andrusko (Author) This digital document is an article from National Right to Life News, published by National Right to Life Committee, Inc. on February 1, 2002. The length of the article is 1142 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Alternative to Embryonic Stem Cells.("multipotent adult progenitor cells" from bone marrow) Author: Dave Andrusko Publication: National Right to Life News (Magazine/Journal) Date: February 1, 2002 Publisher: National Right to Life Committee, Inc. Volume: 29 Issue: 2 Page: NA Distributed by Thomson... | |
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Neuroepithelial Stem Cells and Progenitors (Developmental Neuroscience, 1-2) by S. W. Levinson (Editor), R. S. Nowakowski (Editor) This special issue focuses on recent advances related to stem cells and progenitors in the developing and adult brain. It contains new findings related to the development and fate of the proliferating cells of the central nervous system. Experiments dealing with both in vivo and in vitro results, primarily in cells from the mammalian forebrain, are included. The papers reflect the recent rapid progress in this important field and cover topics such as the cell cycle in fetuses and the use of markers to identify the phenotypes of proliferating cells in culture. Each paper is a report of new and original findings that contribute to the advancement in this field. This excellent publication is of particular value for all neuroscientists, biologists and physicians who are interested in... |
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