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Drug reverses bone loss in men with prostate cancer during the first year of treatment
February 27, 2006Hormone therapy for advanced prostate cancer can lead to bone loss and fractures
SAN FRANCISCO - A common type of treatment used to protect bone density in menopausal women is also an effective therapy for advanced prostate cancer patients during the first year of hormone therapy, according to a new Oregon Health & Science University Cancer Institute study.
"This is important because men treated for advanced prostate cancer are at great risk for losing bone density, which makes the bones vulnerable to fracture," said Christopher Ryan, M.D., a researcher with the OHSU Cancer Institute and lead author of the study. "Hip fractures are especially dangerous and can be life-threatening in older patients."
Hormone therapy, also known as androgen deprivation therapy, is the gold standard of care for men whose prostate cancer is advanced and has spread throughout the body. The therapy works by shutting down male hormones, principally testosterone, that can promote prostate cancer growth. This common treatment for prostate cancer wipes out most male hormones found in the body.
Loss of bone density is a serious side effect of hormone therapy for advanced prostate cancer, a finding that has come to light in recent years. Very low bone density results in a disease called osteoporosis, which is most recognized as a problem in women after menopause. These women are frequently treated with medicines called bisphosphonates that help renew bone growth by inhibiting cells responsible for bone loss.
Ryan studied 120 men with prostate cancer who had been on hormone therapy for up to a year. They found that administration of a bisphosphonate called zoledronic acid every three months significantly increased bone density during the course of 12 months. Men who received a placebo lost bone density.
Zoledronic acid previously has been shown to prevent bone mineral density loss in prostate cancer patients just beginning hormone therapy. "What's new about our study is that it shows starting zoledronic later is still effective and can recover bone density that already has been lost," Ryan said.
Researchers also found a positive effect of zoledronic acid on bone markers, measurements of bone loss that are found in blood and urine. This study supports current guidelines that recommend monitoring bone density of men on hormone therapy and initiating bisphosphonate treatment if the bone density falls.
Prostate cancer is the most common cancer in men and the second leading cause of cancer-related death in American men. Overall, 1 in 6 men will develop prostate cancer during his lifetime.
Oregon Health & Science University
Hormone therapy, also known as androgen deprivation therapy, is the gold standard of care for men whose prostate cancer is advanced and has spread throughout the body. The therapy works by shutting down male hormones, principally testosterone, that can promote prostate cancer growth. This common treatment for prostate cancer wipes out most male hormones found in the body.
Loss of bone density is a serious side effect of hormone therapy for advanced prostate cancer, a finding that has come to light in recent years. Very low bone density results in a disease called osteoporosis, which is most recognized as a problem in women after menopause. These women are frequently treated with medicines called bisphosphonates that help renew bone growth by inhibiting cells responsible for bone loss.
Ryan studied 120 men with prostate cancer who had been on hormone therapy for up to a year. They found that administration of a bisphosphonate called zoledronic acid every three months significantly increased bone density during the course of 12 months. Men who received a placebo lost bone density.
Zoledronic acid previously has been shown to prevent bone mineral density loss in prostate cancer patients just beginning hormone therapy. "What's new about our study is that it shows starting zoledronic later is still effective and can recover bone density that already has been lost," Ryan said.
Researchers also found a positive effect of zoledronic acid on bone markers, measurements of bone loss that are found in blood and urine. This study supports current guidelines that recommend monitoring bone density of men on hormone therapy and initiating bisphosphonate treatment if the bone density falls.
Prostate cancer is the most common cancer in men and the second leading cause of cancer-related death in American men. Overall, 1 in 6 men will develop prostate cancer during his lifetime.
Oregon Health & Science University
Bone Loss Current Events and Bone Loss News RSSConnection between depression and osteoporosis detailed by Hebrew University researchers
Research carried out among thousands of people has shown a clear connection between depression and a loss of bone mass, leading to osteoporosis and fractures.
Women with breast cancer have low vitamin D levels
Women with breast cancer should be given high doses of vitamin D because a majority of them are likely to have low levels of vitamin D, which could contribute to decreased bone mass and greater risk of fractures, according to scientists at the University of Rochester Medical Center.
New link found between osteoporosis and coeliac disease
People with coeliac disease may develop osteoporosis because their immune system attacks their bone tissue, a new study has shown.
Stem cell success points to way to regenerate parathyroid glands
An early laboratory success is taking University of Michigan researchers a step closer to parathyroid gland transplants that could one day prevent a currently untreatable form of bone loss associated with thyroid surgery.
Experimental approach may reverse rheumatoid arthritis and osteoporosis
Researchers have identified a mechanism that may keep a well known signaling molecule from eroding bone and inflaming joints, according to an early study published online today in the Journal of Clinical Investigation.
Space-related radiation research could help reduce fractures in cancer survivors
A research project looking for ways to reduce bone loss in astronauts may yield methods of improving the bone health of cancer patients undergoing radiation treatment.
Prevent periodontitis to reduce the risk of head and neck cancer
Chronic periodontitis, a form of gum disease, is an independent risk factor for head and neck squamous cell carcinoma. This suggests the need for increased efforts to prevent and treat periodontitis as a possible means to reduce the risk of this form of cancer.
Buyer beware: Estrogen supplements not as effective as claimed
Dietary supplements claiming to help postmenopausal women with bone health may not be doing what they say, according to new research from Purdue University.
UCLA scientists uncover immune system's role in bone loss
Got high cholesterol? You might want to consider a bone density test. A new UCLA study sheds light on the link between high cholesterol and osteoporosis and identifies a new way that the body's immune cells play a role in bone loss.
Impact of cannabis on bones changes with age, study finds
Scientists investigating the effects of cannabis on bone health have found that its impact varies dramatically with age.
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