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Hit-and-run injury to the brain
March 02, 2006New evidence on chronic fatigue causation: The 'Dubbo Infection Outcomes Study'
A seven-year tracking study has prompted scientists to suggest that chronic fatigue syndrome could be the result of brain injuries inflicted during the early stages of glandular fever.
Australian researchers have put the suggestion in this week's Journal of Infectious Diseases, which reveals new findings from the 'Dubbo Infection Outcomes Study'. Since 1999, a team led by UNSW Professor Andrew Lloyd have been tracking the long-term health of individuals infected with Epstein-Barr virus (EBV), Ross River virus (RRV) or Q fever infection. Their goal is to discover whether the post-infection fatigue syndrome that may affect up to 100,000 Australians is caused by the persistence of EBV, a weakened immune system, psychological vulnerability, or some combination of these.
Glandular fever - sometimes called 'the kissing disease' - is caused by Epstein-Barr virus (EBV). Transmitted via saliva, its acute symptoms include fever, sore throat, tiredness, and swollen lymph glands. Most patients recover within several weeks but one in ten young people will suffer prolonged symptoms, marked by fatigue. When these symptoms persist in disabling degree for six months or more, the illness may be diagnosed as chronic fatigue syndrome (CFS).
The researchers followed the course of illness among 39 people diagnosed with acute glandular fever. Eight patients developed a 'post-infective fatigue syndrome' lasting six months or longer, while the remaining 31 recovered uneventfully. Detailed studies of the activity of the Epstein-Barr virus in the blood and the immune response against the virus were conducted on blood samples collected from each individual over 12 months.
Commenting on the findings, Professor Lloyd says: "Our findings reveal that neither the virus nor an abnormal immune response explain the post-infective fatigue syndrome. We now suspect it's more like a hit and run injury to the brain.
"We believe that the parts of the brain that control perception of fatigue and pain get damaged during the acute infection phase of glandular fever. If you're still sick several weeks after infection, it seems that the symptoms aren't being driven by the activity of the virus in body, it's happening in the brain.\\\
University of New South Wales
Glandular fever - sometimes called 'the kissing disease' - is caused by Epstein-Barr virus (EBV). Transmitted via saliva, its acute symptoms include fever, sore throat, tiredness, and swollen lymph glands. Most patients recover within several weeks but one in ten young people will suffer prolonged symptoms, marked by fatigue. When these symptoms persist in disabling degree for six months or more, the illness may be diagnosed as chronic fatigue syndrome (CFS).
The researchers followed the course of illness among 39 people diagnosed with acute glandular fever. Eight patients developed a 'post-infective fatigue syndrome' lasting six months or longer, while the remaining 31 recovered uneventfully. Detailed studies of the activity of the Epstein-Barr virus in the blood and the immune response against the virus were conducted on blood samples collected from each individual over 12 months.
Commenting on the findings, Professor Lloyd says: "Our findings reveal that neither the virus nor an abnormal immune response explain the post-infective fatigue syndrome. We now suspect it's more like a hit and run injury to the brain.
"We believe that the parts of the brain that control perception of fatigue and pain get damaged during the acute infection phase of glandular fever. If you're still sick several weeks after infection, it seems that the symptoms aren't being driven by the activity of the virus in body, it's happening in the brain.\\\
University of New South Wales
Chronic Fatigue Syndrome Current Events and Chronic Fatigue Syndrome News RSSMental Fatigue Can Affect Physical Endurance
When participants performed a mentally fatiguing task prior to a difficult exercise test, they reached exhaustion more quickly than when they did the same exercise when mentally rested, a new study finds.
Recalibrating 'fight or flight'
A Canadian/U.S. research team has reported a novel approach to stimulating recovery from chronic stress disorders. Details of the therapeutic model, which exploits the natural dynamics of the body's "fight or flight" system, are published January 23 in the open-access journal PLoS Computational Biology
Sinusitis patients have pain similar to the elderly and people with arthritis
A new analysis led by researchers at Georgetown University Medical Center suggests many patients with sinusitis have aches and pains similar in severity to people in their 80s and those with arthritis or depression.
UI study finds biological link between pain and fatigue
A recent University of Iowa study reveals a biological link between pain and fatigue and may help explain why more women than men are diagnosed with chronic pain and fatigue conditions like fibromyalgia and chronic fatigue syndrome.
Data study suggests cortisol could alleviate for chronic fatigue syndrome and fibromyalgia
Chronic fatigue syndrome (CFS) and fibromyalgia (FM) are two serious and debilitating diseases with no confirmed cause and limited treatment options. However, results of a new comprehensive literature study propose a simplified treatment process that could help alleviate symptoms for patients suffering from these diseases.
Journal SLEEP: Methylphenidate can have sleep benefits in adults with ADHD
Treatment with methylphenidate (MPH) appears to have beneficial effects on sleep parameters in adults with ADHD, including increased sleep efficiency and a feeling of improved restorative value of sleep, according to a study published in the March 1 issue of the journal SLEEP.
Low-intensity exercise reduces fatigue symptoms by 65 percent, study finds
Sedentary people who regularly complain of fatigue can increase their energy levels by 20 percent and decrease their fatigue by 65 percent by engaging in regular, low intensity exercise, according to a new University of Georgia study.
For women, marital distress means less relief from stress
That's the suggestion from a new UCLA study that tracked levels of cortisol, a key stress hormone, among 30 Los Angeles married couples involved in one of our age's trickiest juggling acts - raising kids when both parents work full time.
Researchers hope to provide chronic fatigue syndrome answers
One of the most difficult things for people suffering from Chronic Fatigue Syndrome (CFS) is that many believe the condition to be a psychological, not physical affliction.
Chronic fatigue syndrome linked to stomach virus
Chronic fatigue syndrome, also known as ME (myalgic encephalitis), is linked to a stomach virus, suggests research published ahead of print in Journal of Clinical Pathology.
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