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Screening may over-diagnose 1 in 10 breast cancers
March 03, 2006Rate of overdiagnosis of breast cancer 15 years after the end of Malmö mammographic screening trial: Follow-up study BMJ online first
Screening women for breast cancer could result in a 10% rate of over-diagnosis, finds a study published online by the BMJ today.
Although it is widely agreed that breast screening can reduce deaths, more discussion around this negative side effect of screening is needed, say the authors.
Researchers analysed the rate of over-diagnosis of breast cancer using data from a large breast screening trial conducted in Sweden between 1976 and 1986. Over-diagnosis is defined as cases that would never have come to clinical attention without screening.
They followed trial participants until December 2001, 15 years after the trial ended using national registries to track survival and detection of breast cancer.
Fifteen years after the end of the trial, the rate of over-diagnosis of breast cancer was 10% in women randomised to screening at age 55-69 years compared with an unscreened control group.
Although earlier studies on over-diagnosis have shown rates of up to 54%, a recent study suggests a much lower rate of 1%. But none of these studies were based on direct observations, like the present one, say the authors.
"It is widely agreed that screening using mammography can reduce mortality in breast cancer. The rate of over-diagnosis is another issue to be considered in the ongoing discussion about clinical and public health implications of breast cancer screening," they conclude.
An editorial in this week's BMJ discusses the UK breast screening programme and concludes that, although breast screening by mammography is far from perfect, it does save lives.
BMJ-British Medical Journal
Researchers analysed the rate of over-diagnosis of breast cancer using data from a large breast screening trial conducted in Sweden between 1976 and 1986. Over-diagnosis is defined as cases that would never have come to clinical attention without screening.
They followed trial participants until December 2001, 15 years after the trial ended using national registries to track survival and detection of breast cancer.
Fifteen years after the end of the trial, the rate of over-diagnosis of breast cancer was 10% in women randomised to screening at age 55-69 years compared with an unscreened control group.
Although earlier studies on over-diagnosis have shown rates of up to 54%, a recent study suggests a much lower rate of 1%. But none of these studies were based on direct observations, like the present one, say the authors.
"It is widely agreed that screening using mammography can reduce mortality in breast cancer. The rate of over-diagnosis is another issue to be considered in the ongoing discussion about clinical and public health implications of breast cancer screening," they conclude.
An editorial in this week's BMJ discusses the UK breast screening programme and concludes that, although breast screening by mammography is far from perfect, it does save lives.
BMJ-British Medical Journal
Breast Cancer Screening Current Events and Breast Cancer Screening News RSSStudy finds delay in follow-up among African-American women receiving abnormal breast finding
A new analysis has identified a significant delay in follow-up times among African-American women after the finding of a suspicious breast abnormality.
African-American women still have poorer breast cancer outcomes
New research published in the May issue of the Journal of the American College of Surgeons shows that dramatic disparities in breast cancer outcomes continue to exist for African-American women, regardless of the age at which they are diagnosed, extent of the cancer, type of treatment or socioeconomic status.
Obese women play cancer roulette
Obese women may be putting themselves at greater risk of breast cancer by not undergoing regular screening. According to new research by Dr. Nisa Maruthur and her team from The John Hopkins University School of Medicine in Baltimore, USA, seriously obese women are significantly less likely to say they have undergone a recent mammography than normal weight women, especially if they are white.
Study identifies double-balloon enteroscopy as cost-effective approach for obscure GI bleeding
A cost-effectiveness analysis conducted by researchers at Stanford University Hospital in Calif., shows that an initial double-balloon enteroscopy (DBE) is a cost-effective approach for patients with obscure gastrointestinal (GI) bleeding.
Fear, misconceptions about screenings keep many African-Americans from getting mammograms
Training physicians and caregivers to improve cultural sensitivity and communication with economically disadvantaged African-American patients could influence these women to get mammograms that could save their lives.
MRI spots DCIS in mice
A new magnetic resonance imaging procedure can detect very early breast cancer in mice, including ductal carcinoma in situ (DCIS), a precursor to invasive cancer. Some of the tumors detected were less than 300 microns in diameter, the smallest cancers ever detected by MRI.
Risk of death after cancer diagnosis; shift in stage of breast cancer diagnosis
Cancer patients with low socioeconomic status (SES) have more advanced cancers at diagnosis, receive less aggressive treatment, and have a higher risk of dying in the five years following cancer diagnosis, according to a new study.
Kylie's breast cancer triggered a surge of over 30 percent in breast imaging of low-risk women
Use of mammography and breast ultrasound procedures soared by over 30 percent among women aged 25-44 in the 6 months following Kylie Minogue's breast cancer diagnosis, says a new study from the University of Melbourne.
Adding ultrasound screening to mammography brings benefits, risks
Adding a screening ultrasound examination to routine mammography reveals more breast cancers than mammography alone, according to results of a major new clinical trial. The trial, however, also found that adding an ultrasound exam also increases the rate of false positive findings and unnecessary biopsies.
Mammography may be beneficial to all women, regardless of age
According to researchers at The University of Texas M. D. Anderson Cancer Center, mammography, the gold-standard for breast cancer screening and early detection, has shown to significantly reduce the risk of being diagnosed with advanced stage breast cancer in women over the age of 80, an age group currently without clear guidelines recommending regular screenings.
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