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Liquid crystals show promise in controlling embryonic stem cells
March 08, 2006MADISON-Liquid crystals, the same phase-shifting materials used to display information on cell phones, monitors and other electronic equipment, can also be used to report in real time on the differentiation of embryonic stem cells.
Differentiation is the process by which embryonic stem cells gradually turn into function-specific types of adult cells or so-called "cell lineages," including skin, heart or brain cells.
The main challenge facing stem cell research is that of guiding differentiation along these well-defined, controlled lineages. Stem cells grown in the laboratory tend to differentiate in an uncontrolled manner, resulting in a mixture of cells of little medical use.
Now, University of Wisconsin-Madison researchers at the NSF-funded Materials Research Science and Engineering Center (MRSEC) have shown that by straining mechanically the cells as they grow, it is possible to reduce significantly and almost eliminate the uncontrolled differentiation of stem cells.
In an article in the March issue of Advanced Functional Materials, the team reports on a liquid crystal-based cell culture system that promises new ways of achieving real-time control over interactions between synthetic materials and human embryonic stem cells, including the possibility of straining embryonic stem cells as they grow.
"Stem cells tend to be smaller and have a slightly more compact shape than the differentiated cells," says chemical and biological engineer Sean Palecek. "Differentiated cells appear to be much more spread and they appear to exert different levels of force on the matrix in which they are grown. That force can be read to a liquid crystal. Through simple changes of liquid crystal texture and color, our cell culture system is able to report, in real time, the cell interactions with the underlying support on which they are grown."
Currently, researchers have several methods of monitoring cell differentiation. The easiest, says Palecek, is to just look at the cells and use cell morphology as a cue. A more accurate method uses molecular markers. Antibodies are placed against these markers to determine if they bind to the cell. That system, while more accurate, does not provide real time data and cells often have to be killed in order to analyze the markers.
"This newly devised cell culture system enables a new paradigm in stem cell research," says chemical and biological engineer and MRSEC Director Juan de Pablo. "Ultimately, we hope to use liquid crystalline materials to transmit desired sets of physical and chemical cues to stem cells so as to control their differentiation, as well as report back specific responses of the cells or tissue.
"This research is also significant as an example of our unique effort to integrate advanced materials engineering and embryonic stem cell research, an effort that will help accelerate the rate at which the benefits of stem-cell based therapies are brought to society,\\\
University of Wisconsin-Madison
Now, University of Wisconsin-Madison researchers at the NSF-funded Materials Research Science and Engineering Center (MRSEC) have shown that by straining mechanically the cells as they grow, it is possible to reduce significantly and almost eliminate the uncontrolled differentiation of stem cells.
In an article in the March issue of Advanced Functional Materials, the team reports on a liquid crystal-based cell culture system that promises new ways of achieving real-time control over interactions between synthetic materials and human embryonic stem cells, including the possibility of straining embryonic stem cells as they grow.
"Stem cells tend to be smaller and have a slightly more compact shape than the differentiated cells," says chemical and biological engineer Sean Palecek. "Differentiated cells appear to be much more spread and they appear to exert different levels of force on the matrix in which they are grown. That force can be read to a liquid crystal. Through simple changes of liquid crystal texture and color, our cell culture system is able to report, in real time, the cell interactions with the underlying support on which they are grown."
Currently, researchers have several methods of monitoring cell differentiation. The easiest, says Palecek, is to just look at the cells and use cell morphology as a cue. A more accurate method uses molecular markers. Antibodies are placed against these markers to determine if they bind to the cell. That system, while more accurate, does not provide real time data and cells often have to be killed in order to analyze the markers.
"This newly devised cell culture system enables a new paradigm in stem cell research," says chemical and biological engineer and MRSEC Director Juan de Pablo. "Ultimately, we hope to use liquid crystalline materials to transmit desired sets of physical and chemical cues to stem cells so as to control their differentiation, as well as report back specific responses of the cells or tissue.
"This research is also significant as an example of our unique effort to integrate advanced materials engineering and embryonic stem cell research, an effort that will help accelerate the rate at which the benefits of stem-cell based therapies are brought to society,\\\
University of Wisconsin-Madison
Liquid Crystals Current Events and Liquid Crystals News RSSSpotting evidence of directed percolation
A team of physicists has, for the first time, seen convincing experimental evidence for directed percolation, a phenomenon that turns up in computer models of the ways diseases spread through a population or how water soaks through loose soil.
Breakthrough in industrial-scale nanotube processing
Rice University scientists today unveiled a method for the industrial-scale processing of pure carbon-nanotube fibers that could lead to revolutionary advances in materials science, power distribution and nanoelectronics.
Mantis shrimps could show us the way to a better DVD
The remarkable eyes of a marine crustacean could inspire the next generation of DVD and CD players, according to a new study from the University of Bristol published today in Nature Photonics.
What scientists know about jewel beetle shimmer
"Jewel beetles" are widely known for their glossy external skeletons that appear to change colors as the angle of view changes.
Three-dimensional nanoimaging process provides detailed look at physical properties of liquid crystals
Charles Rosenblatt, professor of physics and macromolecular science at Case Western Reserve University, and his research group have developed a method of 3D optical imaging of anisotropic fluids such liquid crystals, with volumetric resolution one thousand times smaller than existing techniques.
'Superdense' coding gets denser
The record for the most amount of information sent by a single photon has been broken by researchers at the University of Illinois. Using the direction of "wiggling" and "twisting" of a pair of hyper-entangled photons, they have beaten a fundamental limit on the channel capacity for dense coding with linear optics.
Oosight microscope enables embryonic stem cell breakthrough
A noninvasive, polarized light microscope invented at the Marine Biological Laboratory (MBL) played a crucial role in a recent breakthrough in embryonic stem-cell research aimed at developing medical therapies.
Liquid crystal phases of tiny DNA molecules point up new scenario for first life on Earth
A team led by the University of Colorado at Boulder and the University of Milan has discovered some unexpected forms of liquid crystals of ultrashort DNA molecules immersed in water, providing a new scenario for a key step in the emergence of life on Earth.
Princeton engineers develop low-cost recipe for patterning microchips
Creating ultrasmall grooves on microchips -- a key part of many modern technologies -- is about to become as easy as making a sandwich, using a new process invented by Princeton engineers.
UA Physicists Discover 'Super Crystals' in a Semiconductor
University of Arizona physicists have discovered that "super crystals" -- crystals which are hundreds to thousands times larger than conventional crystals -- exist in certain organic semiconducting solids.
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