 |
|
Cancer cells lose drug resistance following electrical stimulation in vitro
March 17, 2006Drug-resistant tumour cells lose their drug resistance when exposed to low intensity, low frequency electric pulses for three days. A study published today in the open access journal BMC Cancer reveals that treating drug-resistant tumour cells with electric pulses in vitro restores the cells' ability to take up the anti-cancer drug doxorubicin.
The research group led by Luca Cucullo and Damir Janigro from the Cleveland Clinic Lerner College of Medicine, Ohio, USA exposed rat and human tumour cells to very low intensity (7.5 microamps) 50 Hertz alternating current pulses, with a ten-second interval, for three days in vitro. Such electrical stimulation is known not to damage cells but to decrease the proliferation of tumour cells. The tumour cell lines used overexpress the MDR1 protein, which makes them resistant to anti-cancer drugs such as doxorubicin. Following the three days of electrical stimulation, the cells were exposed to increasing concentrations of doxorubicin for three hours.
Janigro et al.'s results show that electrical stimulation led to an increased uptake of doxorubicin, which caused the cells to die, even at low doxorubicin concentrations. Exposing the cells to an electric current was more effective than treating the cells with an MDR1 inhibitor. These findings suggest the potential application of electrical stimulation to improve the efficacy of existing chemotherapeutic treatments.
BioMed Central
BioMed Central
Drug Resistance Current Events and Drug Resistance News RSSTargeting blood vessels, immune system may offer way to stop infection-caused inflammation
reating virulent influenza, sepsis, and other potentially deadly infections long has focused on looking for ways to kill viruses and bacteria. But new research from the University of Utah and Utah State University shows that modulating the body's own overeager inflammatory response to infection may help save more lives.
Synergy between 2 types of de-worming drugs found promising in a lab test
A new combination drug treatment for parasitic intestinal roundworms shows promise in a test on a common laboratory species.
Pandemic flu, like seasonal H1N1, shows signs of resisting Tamiflu
If the behavior of the seasonal form of the H1N1 influenza virus is any indication, scientists say that chances are good that most strains of the pandemic H1N1 flu virus will become resistant to Tamiflu, the main drug stockpiled for use against it. Researchers have traced the evolutionary history of the seasonal H1N1 influenza virus, which first infected humans during the 1918 pandemic. It is one of three seasonal influenza A viruses that commonly infect humans. The others are H1N2 and H3N2.
Genomic warfare to counter malaria drug resistance
Scientists battling malaria have earned a major victory. According to a Nature Genetics study, an international group of researchers has used genomics to decode the blueprint of Plasmodium falciparum - a strain of malaria most resistant to drugs that causes the most deaths around the world.
Low levels of antibiotics cause multidrug resistance in 'superbugs'
For years, doctors have warned patients to finish their antibiotic prescriptions or risk a renewed infection by a "superbug" that can mount a more powerful defense against the same drug.
Low forms of cyclin E reduce breast cancer drug's effectiveness
Overexpression of low-molecular-weight (LMW-E) forms of the protein cyclin E renders the aromatase inhibitor letrozole ineffective among women with estrogen-receptor-positive (ER+) breast cancers, researchers from The University of Texas M. D. Anderson Cancer Center report in Clinical Cancer Research.
Iowa State, Ames Lab chemists discover how antiviral drugs bind to and block flu virus
Antiviral drugs block influenza A viruses from reproducing and spreading by attaching to a site within a proton channel necessary for the virus to infect healthy cells, according to a research project led by Iowa State University's Mei Hong and published in the Feb. 4 issue of the journal Nature.
UM School of Medicine scientists find new malaria vaccine is safe and protective in children
A new vaccine to prevent the deadly malaria infection has shown promise to protect the most vulnerable patients - young children - against the disease, according to an international team of researchers led by the University of Maryland School of Medicine's Center for Vaccine Development (CVD) and the Malaria Research and Training Center at the University of Bamako in Mali, West Africa.
Scripps Research scientists find two compounds that lay the foundation for a new class of AIDS drug
A team of scientists at The Scripps Research Institute has identified two compounds that act on novel binding sites for an enzyme used by the human immunodeficiency virus (HIV), the virus that causes AIDS. The discovery lays the foundation for the development of a new class of anti-HIV drugs to enhance existing therapies, treat drug-resistant strains of the disease, and slow the evolution of drug resistance in the virus.
Linheng Li proposes novel theory for mammalian stem cell regulation
Linheng Li, Ph.D., Investigator, together with Hans Clevers, M.D., Ph.D., Director of the Hubrecht Institute in Utrecht, Netherlands, co-authored a prospective review published today by the journal Science that proposes a model of mammalian adult stem cell regulation that may explain how the coexistence of two disparate stem cell states regulates both stem cell maintenance and simultaneously supports rapid tissue regeneration.
More Drug Resistance Current Events and Drug Resistance News Articles
 |
Drug Resistance in Cancer: Mechanisms and Models by James H. Goldie (Author), Andrew J. Coldman (Author) Drug resistance in cancer, whereby a portion of cancer cells evades chemotherapy, poses a profound and continuing challenge for the effective treatment of cancer. The principles underlying the biological mechanisms behind this phenomenon are clearly explained in this volume. A deeper understanding of drug resistance requires a quantitative appreciation of the dynamic forces that shape tumor growth, including spontaneous mutation and selection processes. The authors seek to explain and to simplify these complex mechanisms, and to place them in a clinical context. Clearly explained mathematical models are used to illustrate the biological principles and provide an insight into tumor development and the effectiveness and limitations of drug treatment. The volume is suitable for those with... |
 |
Antibiotic Resistance: Stopping the Superbugs Directed By: ITV Also With: ITV (Producer) |
 |
Dead or Alive: Final Starring: Shô Aikawa, Maria Chen, Richard Chen, Jason Chu, Josie Ho Directed By: Takashi Miike Also With: Ken Takeuchi (Producer), Makoto Okada (Producer), Mitsuru Kurosawa (Producer), Toshiki Kimura (Producer), Hitoshi Ishikawa (Writer), Ichiro Ryu (Writer), Yoshinobu Kamo (Writer) The ace cop of a totalitarian police force and a drifting android play their parts in a post-apocalyptic society. They are destined to fight. Their encounter will change them forever. Studio: Kino International Release Date: 10/05/2004 Run time: 88 minutes |
 |
Drug Abuse Resistance Education Awareness Ribbon Mouse Pad by MyHeritageWear.com The Drug Abuse Resistance Education proudly displayed on a mouse pad. There is no better way to achieve awareness for the meaning of the Drug Abuse Resistance Education than to display it on your mouse pad for everyone to see. The mouse pad measures at 9.25 x 7.75, it is machine washable, and the colors will not fade or run. Start gaining awareness today by presenting your Drug Abuse Resistance Education mouse pad at work or at home. It is certain to keep your mouse rolling in style all while gaining support and awareness! |
 |
Antibiotics: Actions, Origins, Resistance by Christopher Walsh (Author) Harvard Medical School, Boston, MA. Text analyzes how small molecules interfere selectively with the processes central to the survival of bacterial cells. Focuses on the relatively few molecules in antibiotics having an impact on human infectious disease. DNLM: Antibiotics--pharmacology. |
 |
Science Magazine July 18 2008 Drug Resistance by Science Magazine |
|
Molecular Genetics of Drug Resistance (Modern Genetics) by Hayes (Author) Drug resistance is a growing problem in today's society. Successful drugs are constantly being developed but there is always the risk that a small percent of the drug's target will be immune. These survivors can then lead to a new population, resistant to the action of this drug. New drugs are continuously under development to combat this problem, but these can, in turn, lead to new resistant populations. This problem is universal whether the target is to destroy a deadly virus, or an insect which is ravaging crop production. Development of new drugs is difficult and time consuming so it is of crucial importance that we understand the processes behind drug resistance. Molecular Genetics of Drug Resistance forms a vital and timely review of the genetic processes behind drug ... | |
 |
PILL CONTAINER - First Aid - MEDICAL ALERT - Key Chain with Water Resistance - Large Size / Color BLACK by Changsheng Hardware |
 |
Antimicrobial Drug Resistance: Clinical and Epidemiological Aspects, Volume 2 (Infectious Disease) by Douglas Mayers (Editor) The volumes included in Antimicrobial Drug Resistance represent the first comprehensive, multidisciplinary reference covering the area of antimicrobial drug resistance in bacteria, fungi, viruses, and parasites from basic science, clinical, and epidemiological perspectives. This second volume, Antimicrobial Drug Resistance, Clinical and Epidemiological Aspects, is devoted to the clinical aspects of drug resistance. Although there is evidence that restricted use of a specific antibiotic can be followed by a decrease in drug resistance to that agent, drug resistance control is not easily achieved. Thus, the infectious disease physician requires input from the clinical microbiologist and infection control specialist to make informed choices for the effective treatment of various... |
 |
Revenge Of The Microbes: How Bacterial Resistance Is Undermining The Antibiotic Miracle by Abigail A. Salyers (Author), Dixie D. Whitt (Author) 'What is antibiotic resistance, and why should I be concerned with it?' Media coverage and political and scientific discussions about 'superbugs' that defy our current treatments, genetically-modified foods in our fields and grocery stores, the threat of bioterrorism, and the use of antibiotics in agriculture have increased citizen awareness and fears regarding the issues surrounding antibiotic resistance. "Revenge of the Microbes: How Bacterial Resistance Is Undermining the Antibiotic Miracle" is a single source of answers to this and other questions average people are asking. Written by experts with extensive experience in the field, "Revenge of the Microbes" provides the scientific information readers will need to form opinions and make informed decisions regarding the use of... |
| © 2010 BrightSurf.com |