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Cancer cells lose drug resistance following electrical stimulation in vitro
March 17, 2006Drug-resistant tumour cells lose their drug resistance when exposed to low intensity, low frequency electric pulses for three days. A study published today in the open access journal BMC Cancer reveals that treating drug-resistant tumour cells with electric pulses in vitro restores the cells' ability to take up the anti-cancer drug doxorubicin.
The research group led by Luca Cucullo and Damir Janigro from the Cleveland Clinic Lerner College of Medicine, Ohio, USA exposed rat and human tumour cells to very low intensity (7.5 microamps) 50 Hertz alternating current pulses, with a ten-second interval, for three days in vitro. Such electrical stimulation is known not to damage cells but to decrease the proliferation of tumour cells. The tumour cell lines used overexpress the MDR1 protein, which makes them resistant to anti-cancer drugs such as doxorubicin. Following the three days of electrical stimulation, the cells were exposed to increasing concentrations of doxorubicin for three hours.
Janigro et al.'s results show that electrical stimulation led to an increased uptake of doxorubicin, which caused the cells to die, even at low doxorubicin concentrations. Exposing the cells to an electric current was more effective than treating the cells with an MDR1 inhibitor. These findings suggest the potential application of electrical stimulation to improve the efficacy of existing chemotherapeutic treatments.
BioMed Central
BioMed Central
Drug Resistance Current Events and Drug Resistance News RSSTaking aim at mysterious DNA structures in the battle against cancer
Designers of anti-cancer drugs are aiming their arrows at mysterious chunks of the genetic material DNA that may play a key role in preventing the growth and spread of cancer cells, according to an article in the current issue of Chemical & Engineering News, ACS' weekly newsmagazine.
There's a speed limit to the pace of evolution, Penn biologists say
Researchers at the University of Pennsylvania have developed a theoretical model that informs the understanding of evolution and determines how quickly an organism will evolve using a catalogue of "evolutionary speed limits."
Ineffective monotherapies common in high-burden malarious countries
ACTwatch, a research project led by PSI, in collaboration with the London School of Hygiene and Tropical Medicine, released evidence today that indicates that artemisinin combination therapy, the most effective medicines for treating malaria, continue to have a significantly low presence on the market among populations considered to be most at risk.
Paradigm shift needed to combat drug resistance
When people travel, bacteria and other infectious agents travel with them. As about a billion people cross international borders each year, many more billions of the bugs come along for the ride.
UM School of Medicine researchers find extreme genetic variability in malaria parasite
Researchers at the University of Maryland School of Medicine Center for Vaccine Development (CVD) have charted the extreme genetic differences that occur over time in the most dangerous malaria parasite in the world.
Scientists join forces to explain HIV spread in Central and East Africa
Scientists studying biology and geography may seem worlds apart, but together they have answered a question that has defied explanation about the spread of the HIV-1 epidemic in Africa.
Pancreatic cancer: Researchers find drug that reverses resistance to chemotherapy
For the first time researchers have shown that by inhibiting the action of an enzyme called TAK-1, it is possible to make pancreatic cancer cells sensitive to chemotherapy, opening the way for the development of a new drug to treat the disease.
MUHC/McGill researchers to WHO: Time to revise tuberculosis treatment guidelines
Tuberculosis is a global threat that affects more than 10 million people each year. Working with colleagues in the United States and France, Dr. Dick Menzies of the Research Institute of the McGill University Health Centre (RI-MUHC) has placed current tuberculosis treatment guidelines under the microscope in a new study.
Man-made crises 'outrunning our ability to deal with them,' scientists warn
The world faces a compounding series of crises driven by human activity, which existing governments and institutions are increasingly powerless to cope with, a group of eminent environmental scientists and economists has warned.
New research strategy for understanding drug resistance in leukemia
UCSF researchers have developed a new approach to identify specific genes that influence how cancer cells respond to drugs and how they become resistant. This strategy, which involves producing diverse genetic mutations that result in leukemia and associating specific mutations with treatment outcomes, will enable researchers to better understand how drug resistance occurs in leukemia and other cancers, and has important long-term implications for the development of more effective therapies.
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