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Environmental chemicals implicated in cancer, say experts
March 20, 2006New research at the University of Liverpool suggests that environmental contaminants, such as pesticides, are more influential in causing cancer than previously thought.
Previous studies in cancer causation have often concluded that exposure to carcinogenic or endocrine-disrupting chemicals, for example, organochlorines (OC)-found in pesticides and plastics-occurs at concentrations that are too low to be considered a major factor in cancerous disease. Now new research at the University of Liverpool, published in the Journal of Nutritional and Environmental Medicine, has found that exposure even to small amounts of these chemicals may result in an increased risk of developing cancer-particularly for infants and young adults.
The research consisted of systematic reviewing of recent studies and literature concerning the environment and cancer, and was supported by the Cancer Prevention and Education Society. Professor Vyvyan Howard and John Newby, from the University's Department of Human Anatomy and Cell Biology, also found that genetic variations, which can predispose some people to cancer, may interact with environmental contaminants and produce an enhanced effect.
Professor Howard said: "Organochlorines are persistent organic pollutants (POPs), which disperse over long distances and bioaccumulate in the food chain. For humans the main source of OC exposure is from diet, primarily through meat and dairy products. Children are exposed to dioxin, a by-product of OCs, through food; dioxin and other POPs can also cross the placenta and endanger babies in the womb. Breastfed infants can be exposed to OCs with endocrine disrupting properties that have accumulated in breast milk. Our research looks at involuntary exposure to these chemicals in the air, food and water.
"Environmental contaminants-in particular synthetic pesticides and organochlorines with hormone-disrupting properties-could be a major factor in causing hormone-dependent malignancies such as breast, testicular and prostate cancers. Preventative measures for these types of cancer have focused on educating the public about the danger of tobacco smoke, improving diet and promoting physical activity. We should now, however, be focusing on trying to reduce exposure to problematic chemicals."
The research team has also looked at anecdotal evidence, from practicing physicians in pre-industrial societies, which suggests that cancerous disease was rare amongst particular communities, such as the Canadian Inuits and Brazilian Indians. This suggests that cancer is a disease of industrialisation.
Professor Howard added: "The World Health Organisation estimates that between one and five percent of malignant disease in developed countries is attributed to environmental factors; but our research suggests this figure may have been underestimated."
Jamie Page, Chairman of Cancer Prevention and Education said: "This research is very important and suggests that there are links between chemicals and cancer. It is our opinion that if progress if to be made in the fight against cancer, far more attention and effort must be made to reduce human exposure to harmful chemicals.\\\
University of Liverpool
Professor Howard said: "Organochlorines are persistent organic pollutants (POPs), which disperse over long distances and bioaccumulate in the food chain. For humans the main source of OC exposure is from diet, primarily through meat and dairy products. Children are exposed to dioxin, a by-product of OCs, through food; dioxin and other POPs can also cross the placenta and endanger babies in the womb. Breastfed infants can be exposed to OCs with endocrine disrupting properties that have accumulated in breast milk. Our research looks at involuntary exposure to these chemicals in the air, food and water.
"Environmental contaminants-in particular synthetic pesticides and organochlorines with hormone-disrupting properties-could be a major factor in causing hormone-dependent malignancies such as breast, testicular and prostate cancers. Preventative measures for these types of cancer have focused on educating the public about the danger of tobacco smoke, improving diet and promoting physical activity. We should now, however, be focusing on trying to reduce exposure to problematic chemicals."
The research team has also looked at anecdotal evidence, from practicing physicians in pre-industrial societies, which suggests that cancerous disease was rare amongst particular communities, such as the Canadian Inuits and Brazilian Indians. This suggests that cancer is a disease of industrialisation.
Professor Howard added: "The World Health Organisation estimates that between one and five percent of malignant disease in developed countries is attributed to environmental factors; but our research suggests this figure may have been underestimated."
Jamie Page, Chairman of Cancer Prevention and Education said: "This research is very important and suggests that there are links between chemicals and cancer. It is our opinion that if progress if to be made in the fight against cancer, far more attention and effort must be made to reduce human exposure to harmful chemicals.\\\
University of Liverpool
Environmental Chemicals Current Events and Environmental Chemicals News RSSNTP finalizes report on Bisphenol A
Current human exposure to bisphenol A (BPA), a chemical used in many polycarbonate plastics and epoxy resins, is of "some concern" for effects on development of the prostate gland and brain and for behavioral effects in fetuses, infants and children, according to a final report released today by the National Toxicology Program (NTP).
Aerosol toxins from red tides may cause long-term health threat
NOAA scientists reported in the current issue of the journal Environmental Health Perspectives that an algal toxin commonly inhaled in sea spray, attacks and damages DNA in the lungs of laboratory rats.
How DDT metabolite disrupts breast cancer cells
Research has shown that the main metabolite of the insecticide DDT could be associated with aggressive breast cancer tumours, but there has been no explanation for this observation to date. Now a report published in the open access journal Breast Cancer Research shows how DDT could act to disrupt hormone-sensitive breast cancer cells.
Maternal beef diet could impact sperm counts, UR study suggests
A mother's high beef consumption while pregnant was associated with lower sperm counts in her son, according to a study led by researchers at the University of Rochester.
Obesity And Environmental Chemicals: Research Probes Potential Link
A team of researchers at UNH is investigating whether the increasing ubiquity of chemical flame retardants found in foam furniture, carpeting, microwaves and computers might be related to the climbing rate of obesity in the United States.
Exposure to dioxins influences male reproductive system, study of Vietnam veterans concludes
A dioxin toxin contained in the herbicide Agent Orange affects male reproductive health by limiting the growth of the prostate gland and lowering testosterone levels.
A silent pandemic: Industrial chemicals are impairing the brain development of children worldwide
Fetal and early childhood exposures to industrial chemicals in the environment can damage the developing brain and can lead to neurodevelopmental disorders (NDDs)-autism, attention deficit disorder (ADHD), and mental retardation.
Breast-feeding still best despite environmental chemicals in human milk
The presence of environmental chemicals in human milk does not necessarily indicate health risks for infants, according to researchers.
Human embryonic stem cells have the potential to develop into eggs and sperm in the laboratory
Scientists in the UK have proved that human embryonic stem cells can develop in the laboratory into the early forms of cells that eventually become eggs or sperm.
Fundamental facts about environmental hormones: text of speech by Dr Susan Jobling at the BA Festival of Science 2004
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