High-dose vitamin C as a cancer therapyMarch 28, 2006Although early clinical studies conducted by Linus Pauling showed that high-dose vitamin C, given by intravenous and oral routes, may improve symptoms and prolong life in patients with terminal cancer, no benefits for cancer patients were seen when vitamin C therapy was administered orally in double-blind placebo-controlled studies at the Mayo Clinic. Since then, high doses of vitamin C have been used only as an "alternative" therapy to standard cancer treatment. However, recent evidence shows that intravenous administration of the maximum tolerated dose of vitamin C produces plasma concentrations about 25 times higher than when the vitamin is administered orally. At concentrations above 1000 mmol/L - which can only be achieved by the intravenous route - vitamin C is toxic to some cancer cells but not to normal cells in vitro. Padayatty and colleagues report on 3 well-documented cases of advanced cancers, confirmed by histopathologic review, where patients had unexpectedly long survival times after receiving high-dose intravenous vitamin C therapy. They assessed the clinical details of each case in accordance with National Cancer Institute (NCI) Best Case Series guidelines, and found that the case reports indicate that the role of high-dose intravenous vitamin C therapy in cancer treatment should be reassessed. Canadian Medical Association Journal |
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| Related Vitamin C Current Events and Vitamin C News Articles Fruit juices contain more vitamin C than their labels indicate A team of pharmacists from the University of Santiago de Compostela (USC) has established that the levels of vitamin C in many fruit juices and soft drinks are far higher than those indicated on their labels by the manufacturers. First global scientific conference supporting UN efforts to curb desertification opens in Argentina As climate change negotiators continue to skirt the role of agricultural land use in reducing greenhouse gas emissions, top scientists working on land management in the world's vast dry areas will gather this week in Buenos Aires, Argentina, determined to make the case that thwarting desertification in drylands is viable and also critical to the success of a new climate deal. Green tea component may help preserve stored platelets, tissues In two separate studies, a major component in green tea, epigallocatechin-3-O-gallate (EGCG), has been found to help prolong the preservation of both stored blood platelets and cryopreserved skin tissues. Model backs green tea and lemon claim, lessens need to test animals An animal study at Purdue University has shown that adding ascorbic acid and sugar to green tea can help the body absorb helpful compounds and also demonstrates the effectiveness of a model that could reduce the number of animals needed for these types of studies. UAB/Southern Research Scientists Discover How Flu Damages Lung Tissue A protein in influenza virus that helps it multiply also damages lung epithelial cells, causing fluid buildup in the lungs, according to new research from the University of Alabama at Birmingham (UAB) and Southern Research Institute. Melon research sweetened with DNA sequence People smell them, thump them and eyeball their shape. But ultimately, it's sweetness and a sense of healthy eating that lands a melon in a shopper's cart. Many breast cancer patients take high doses of antioxidants despite possible consequences A new study finds that many women with breast cancer take antioxidant supplements while undergoing cancer treatment, even though the consequences of doing so are unknown. Many breast cancer patients take high doses of antioxidants despite possible consequences A new study finds that many women with breast cancer take antioxidant supplements while undergoing cancer treatment, even though the consequences of doing so are unknown. New fuel cell catalyst uses 2 metals Material scientists at Washington University in St. Louis have developed a technique for a bimetallic fuel cell catalyst that is efficient, robust and two to five times more effective than commercial catalysts. Research suggests vegetable juice may help people with metabolic syndrome lose weight Drinking at least one glass of low sodium vegetable juice daily may help overweight people with metabolic syndrome achieve better weight loss results. More Vitamin C Current Events and Vitamin C News Articles |
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