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Fat cells around coronary arteries may play a role in heart disease
April 05, 2006The fat cells that surround coronary arteries may play a central and previously unrecognized role in development of cardiovascular disease, according to a study by University of Iowa researchers.
Dr. Lynn Stoll presented the research team's findings on April 4 at Experimental Biology 2006 in San Francisco. Her presentation was part of the scientific program of the American Society of Investigative Pathology.
Once thought of as mere storage depots for excess energy, fat cells ("adipocytes") are now known to be highly active metabolically, releasing potent pro-inflammatory proteins and hormones that regulate inflammation, blood pressure, insulin activity, and other biological processes. Where fat cells are located has a major influence on their impact, as seen in the fact that visceral fat surrounding the internal organs ("apple" body shape) is far more highly correlated with development of diabetes and cardiovascular disease than subcutaneous fat in the thighs and buttocks (pear\\\
Federation of American Societies for Experimental Biology
Federation of American Societies for Experimental Biology
Fat Cells Current Events and Fat Cells News RSSNewly identified cells make fat
To understand where fat comes from, you have to start with a skinny mouse. By using such a creature, and observing the growth of fat after injections of different kinds of immature cells, scientists at the Howard Hughes Medical Institute and Rockefeller University have discovered an important fat precursor cell that may in time explain how changes in the numbers of fat cells might increase and lead to obesity.
Making metabolism more inefficient can reduce obesity
In a discovery that counters prevailing thought, a study in mice has found that inactivating a pair of key genes involved in "fat-burning" can actually increase energy expenditure and help lower diet-induced obesity. These unusual findings, appearing this week in the JBC, might lead to some new roads in weight-loss therapy.
Healthy blood vessels may prevent fat growth
The cells lining blood vessels are known to be important for maintaining health, but researchers at the Indiana University School of Medicine believe these cells may perform an unsuspected task - controlling the development of fat cells.
Not all fat is created equal
A Temple University study finds fat in obese patients is "sick" when compared to fat in lean patients.
Scientists discover leptin can also aid type 1 diabetics
Terminally ill rodents with type 1 diabetes have been restored to full health with a single injection of a substance other than insulin by scientists at UT Southwestern Medical Center.
Making 'good' fat from muscle and vice versa
A surprise discovery -- that calorie-burning brown fat can be produced experimentally from muscle precursor cells in mice -- raises the prospect of new ways to fight obesity and overweight, say scientists from Dana-Farber Cancer Institute.
Joslin study identifies protein that produces 'good' fat
A study by researchers at the Joslin Diabetes Center has shown that a protein known for its role in inducing bone growth can also help promote the development of brown fat, a "good" fat that helps in the expenditure of energy and plays a role in fighting obesity.
Protein made by fat cells may increase risk of heart attack in older adults
Adiponectin, a protein produced by fat cells, may play a pivotal and counterintuitive role in cardiovascular health for older Americans according to a new study accepted for publication in the Journal of Clinical Endocrinology & Metabolism (JCEM).
Small protein may have big role in making more bone and less fat
A small protein may have a big role in helping you make more bone and less fat, researchers say.
Systems properties of insulin signaling revealed
A team of Swedish researchers has characterized novel systems properties of insulin signaling in human fat cells. Their mathematical modeling, described in an article published June 20th in the open-access journal PLoS Computational Biology, provides further insight into energy level maintenance (via the hormone insulin) within our bodies.
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