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Rewind, please: Nature paper shows that cell division is reversible
April 13, 2006Discovery could open doors for treatment of cancer, birth defects
Oklahoma City-Gary J. Gorbsky, Ph.D., a scientist with the Oklahoma Medical Research Foundation, has found a way to reverse the process of cell division.
The discovery could have important implications for the treatment of cancer, birth defects and numerous other diseases and disorders. Gorbsky's findings appear in the April 13 issue of the journal Nature.
"No one has gotten the cell cycle to go backwards before now," said Gorbsky, who holds the W.H. and Betty Phelps Chair in Developmental Biology at OMRF. "This shows that certain events in the cell cycle that have long been assumed irreversible may, in fact, be reversible."
Cell division occurs millions of times each day in the human body and is essential to life itself. In the lab, Gorbsky and his OMRF colleagues were able to control the protein responsible for the division process, interrupt and reverse the event, sending duplicate chromosomes back to the center of the original cell, an event once thought impossible.
"Our studies indicate that the factors pointing cells toward division can be turned and even reversed," Gorbsky said. "If we wait too long, however, it doesn't work, so we know that there are multiple regulators in the cell division cycle. Now we will begin to study the triggers that set these events in motion."
The findings may prove important to controlling the development and metastasis of certain cancers. It also holds promise for the prevention and treatment of birth defects and a wide variety of other conditions.
"Dr. Gorbsky's results provide elegant proof that the cell cycle must be precisely controlled," said Dr. Rodger McEver, OMRF vice president of research. "Now he and his lab can work toward developing innovative methods to probe and better understand the complex process of cell division."
Gorbsky heads the Molecular, Cell and Developmental Biology Research Program at OMRF and holds both an M.A. and a Ph.D. in biology from Princeton University. He is also adjunct professor of Cell Biology at the University of Oklahoma Health Sciences Center and a member of the OU Cancer Institute. His research focuses on mitosis and cytokinesis, the processes involved in cell division, and he has earned international recognition for his work in the area of chromosomal movement and cell cycle control.
Oklahoma Medical Research Foundation
"No one has gotten the cell cycle to go backwards before now," said Gorbsky, who holds the W.H. and Betty Phelps Chair in Developmental Biology at OMRF. "This shows that certain events in the cell cycle that have long been assumed irreversible may, in fact, be reversible."
Cell division occurs millions of times each day in the human body and is essential to life itself. In the lab, Gorbsky and his OMRF colleagues were able to control the protein responsible for the division process, interrupt and reverse the event, sending duplicate chromosomes back to the center of the original cell, an event once thought impossible.
"Our studies indicate that the factors pointing cells toward division can be turned and even reversed," Gorbsky said. "If we wait too long, however, it doesn't work, so we know that there are multiple regulators in the cell division cycle. Now we will begin to study the triggers that set these events in motion."
The findings may prove important to controlling the development and metastasis of certain cancers. It also holds promise for the prevention and treatment of birth defects and a wide variety of other conditions.
"Dr. Gorbsky's results provide elegant proof that the cell cycle must be precisely controlled," said Dr. Rodger McEver, OMRF vice president of research. "Now he and his lab can work toward developing innovative methods to probe and better understand the complex process of cell division."
Gorbsky heads the Molecular, Cell and Developmental Biology Research Program at OMRF and holds both an M.A. and a Ph.D. in biology from Princeton University. He is also adjunct professor of Cell Biology at the University of Oklahoma Health Sciences Center and a member of the OU Cancer Institute. His research focuses on mitosis and cytokinesis, the processes involved in cell division, and he has earned international recognition for his work in the area of chromosomal movement and cell cycle control.
Oklahoma Medical Research Foundation
Cell Division Current Events and Cell Division News RSSParadoxical protein might prevent cancer
One difficulty with fighting cancer cells is that they are similar in many respects to the body's stem cells. By focusing on the differences, researchers at Karolinska Institutet have found a new way of tackling colon cancer. The study is presented in the prestigious journal Cell.
Study reveals why certain drug combinations backfire
Combination drug therapy has become a staple for treating many infections. For instance, doctors treat extensively drug resistant forms of tuberculosis with one drug that breaks down the pathogen's protective barriers and opens the door for another to deliver the deathblow.
Sponges recycle carbon to give life to coral reefs
Coral reefs support some of the most diverse ecosystems on the planet, yet they thrive in a marine desert. So how do reefs sustain their thriving populations?
Researchers discover mechanism that prevents two species from reproducing
Cornell researchers have discovered a genetic mechanism in fruit flies that prevents two closely related species from reproducing, a finding that offers clues to how species evolve.
Common weed could provide clues on aging and cancer
A common weed and human cancer cells could provide some very uncommon details about DNA structure and its relationship with telomeres and how they affect cellular aging and cancer, according to a team led by scientists from Texas A&M University and the University of Cincinnati (UC).
Boston University scientists first to see RNA network in live bacterial cells
Scientists who study RNA have faced a formidable roadblock: trying to examine RNA's movements in a living cell when they can't see the RNA. Now, a new technology has given scientists the first look ever at RNA in a live bacteria cell-a sight that could offer new information about how the molecule moves and works.
Texas A&M researchers find new mechanism for circadian rhythm
Molecules that may hold the key to new ways to fight cancer and other diseases have been found to play an important role in regulating circadian rhythm, says Liheng Shi, a researcher in Texas A&M's Department of Veterinary Integrative Biosciences.
Checkered history of mother and daughter cells explains cell cycle differences
When mother and daughter cells are created each time a cell divides, they are not exactly alike. They have the same set of genes, but differ in the way they regulate them.
Eutrophication affects diversity of algae
Eutrophication of the seas may have an impact on genetic variation in algae, research at the University of Gothenburg shows.
MDC scientists show how hematopoietic stem cell development is regulated
During cell division, whether hematopoietic stem cells (HSCs) will develop into new stem cells (self-renewal) or differentiate into other blood cells depends on a chemical process called DNA methylation.
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