 |
|
Microfluidic device tests fluid compatibility
April 18, 2006The key to a great party is inviting guests who mix well and don't instill tension among their fellow revelers. The key to a great detergent, cosmetic, paint or other complex liquid product is pretty much the same-include components that mix well and don't have high levels of what scientists call "interfacial tension," a tendency to bead up and pull away from each other.
To help industrial engineers improve their ability to systematically test new product formulations, researchers at the National Institute of Standards and Technology (NIST) have developed a microfluidic instrument that quickly measures interfacial tension.
The instrument is relatively simple and includes a series of channels ranging from 700 micrometers to 50 micrometers wide. Fluids are pumped toward a "T" intersection where drops of one liquid are pinched off and flow along a "river" of the second liquid. As the spherical drops flow through constriction points in the channel, they speed up and elongate. The degree to which the drops stretch out depends on the interfacial tension between the two fluids. High levels of tension exert more pressure on the drops, keeping them more nearly spherical.
Just as the mood of a party goes through stages, the tension between newly mixed liquids can change over time, and the device tracks these changes as the drops move downstream through the channel. A camera captures 100 pictures per second to record the changes, and an algorithm analyzes the data and produces a measurement in approximately 1 second.
Reporting on their work in the March issue of the journal Lab on a Chip, the researchers say they expect that the device will be especially useful to test fresh interfaces for applications with scarce amounts of the fluids to be tested such as custom-synthesized materials from combinatorial chemistry.
National Institute of Standards and Technology (NIST)
Just as the mood of a party goes through stages, the tension between newly mixed liquids can change over time, and the device tracks these changes as the drops move downstream through the channel. A camera captures 100 pictures per second to record the changes, and an algorithm analyzes the data and produces a measurement in approximately 1 second.
Reporting on their work in the March issue of the journal Lab on a Chip, the researchers say they expect that the device will be especially useful to test fresh interfaces for applications with scarce amounts of the fluids to be tested such as custom-synthesized materials from combinatorial chemistry.
National Institute of Standards and Technology (NIST)
Microfluidic Device Current Events and Microfluidic Device News RSSNovel NIST connector uses magnets for leak-free microfluidic devices
Like other users of microfluidic systems, National Institute of Standards and Technology (NIST) researcher Javier Atencia was faced with an annoying engineering problem: how to simply, reliably and most of all, tightly, connect his tiny devices to the external pumps and reservoirs delivering liquids into the system.
Tiny injector to speed development of new, safer, cheaper drugs
It's no bigger than a stamp packet but it has the potential to allow rapid development of a new generation of drugs and genetic engineering organisms, and to better control in-vitro fertilization.
New nanochemistry technique encases single molecules in microdroplets
Inventing a useful new tool for creating chemical reactions between single molecules, scientists at the National Institute of Standards and Technology (NIST) have employed microfluidics-the manipulation of fluids at the microscopic scale-to make microdroplets that contain single molecules of interest.
NIST calculations may improve temperature measures for microfluidics
If you wanted to know if your child had a fever or be certain that the roast in the oven was thoroughly cooked, you would, of course, use a thermometer that you trusted to give accurate readings at any temperature within its range.
Music is the engine of new U-M lab-on-a-chip device
Music, rather than electromechanical valves, can drive experimental samples through a lab-on-a-chip in a new system developed at the University of Michigan. This development could significantly simplify the process of conducting experiments in microfluidic devices.
New lab-on-a-chip measures mechanics of bacteria colonies
Researchers at the University of Michigan have devised a microscale tool to help them understand the mechanical behavior of biofilms, slimy colonies of bacteria involved in most human infectious diseases.
Separating the good from the bad
Scientists at MIT and Brown University studying how marine bacteria move recently discovered that a sharp variation in water current segregates right-handed bacteria from their left-handed brethren, impelling the microbes in opposite directions.
MIT paves way to 'artificial nose'
MIT biological engineers have found a way to mass-produce smell receptors in the laboratory, an advance that paves the way for "artificial noses" to be created and used in a variety of settings.
Make your own microfluidic device with new kit from U-M
A type of device called a "lab-on-a-chip" could bring a new generation of instant home tests for illnesses, food contaminants and toxic gases. But today these portable, efficient tools are often stuck in the lab themselves. Specifically, in the labs of researchers who know how to make them from scratch.
Automated microfluidic device reduces time to screen small organisms for genetic studies
Genetic studies on small organisms such as worms and flies can now be done more quickly using a new microfluidic device developed by engineers at the Georgia Institute of Technology.
More Microfluidic Device Current Events and Microfluidic Device News Articles
 |
Optofluidics: Fundamentals, Devices, and Applications (Biophotonics) by Yeshaiahu Fainman (Author), Luke Lee (Author), Demetri Psaltis (Author), Changhuei Yang (Author) Cutting-Edge Optofluidics Theories, Techniques, and Practices Add novel functionalities to your optical design projects by incorporating state-of-the-art microfluidic technologies and tools. Co-written by industry experts, Optofluidics: Fundamentals, Devices, and Applications covers the latest functional integration of optical devices and microfluidics, as well as automation techniques. This authoritative guide explains how to fabricate optical lab-on-a-chip devices, synthesize photonic crystals, develop solid and liquid core waveguides, use fluidic self-assembly methods, and accomplish direct microfabrication in solutions. The book includes details on developing biological sensors and arrays, handling maskless lithography, designing high-Q cavities, and working with... |
![Rapid discrimination of single-nucleotide mismatches using a microfluidic device with monolayered beads [An article from: Analytica Chimica Acta]](http://ecx.images-amazon.com/images/I/415FBN4EPVL._SL160_.jpg) |
Rapid discrimination of single-nucleotide mismatches using a microfluidic device with monolayered beads [An article from: Analytica Chimica Acta] by J.K.K. Ng (Author), H. Feng (Author), W.T. Liu (Author) This digital document is a journal article from Analytica Chimica Acta, published by Elsevier in 2007. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser. Description: A microfluidic device incorporating monolayered beads is developed for the discrimination of single-nucleotide mismatches, based on the differential dissociation kinetics between perfect match (PM) and mismatched (MM) duplexes. The monolayered beads are used as solid support for the immobilization of oligonucleotide probes containing a single-base variation. Target oligonucleotides hybridize to the probes, forming either PM duplexes or MM duplexes containing a single mismatch. Optimization studies show that PM... |
|
Real-time monitoring of injection molding for microfluidic devices using ultrasound.: An article from: Polymer Engineering and Science by Y. Ono (Author), C.-K. Jen (Author), C.-C. Cheng (Author), M. Kobayashi (Author) This digital document is an article from Polymer Engineering and Science, published by Society of Plastics Engineers, Inc. on April 1, 2005. The length of the article is 4015 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. From the author: Real-time process monitoring of the fabrication process of microfluidic devices using a polymer injection molding machine was carried out using miniature ultrasonic probes. A thick piezoelectric lead-zirconate-titanate film as an ultrasonic transducer (UT) was fabricated onto one end of a 4-mm diameter and 12-mm long steel buffer rods using a sol gel spray technique.... | |
|
|
Continuous flow microfluidic device for cell separation, cell lysis and DNA purification [An article from: Analytica Chimica Acta] by X. Chen (Author), D. Cui (Author), C. Liu (Author), H. Li (Author), J. Chen (Author) This digital document is a journal article from Analytica Chimica Acta, published by Elsevier in 2007. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser. Description: A novel integrated microfluidic device that consisted of microfilter, micromixer, micropillar array, microweir, microchannel, microchamber, and porous matrix was developed to perform sample pre-treatment of whole blood. Cell separation, cell lysis and DNA purification were performed in this miniaturized device during a continuous flow process. Crossflow filtration was proposed to separate blood cells, which could successfully avoid clogging or jamming. After blood cells were lyzed in guanidine buffer, genomic... |
|
Microfluidic Devices in Nanotechnology: Current Status and a Future Perspective by Challa S. S. R. Kumar (Author) Nanotechnology, especially microfabrication, has been affecting every facet of traditional scientific disciplines. The first book on the application of microfluidic reactors in nanotechnology, Microfluidic Devices in Nanotechnology provides the fundamental aspects and potential applications of microfluidic devices, the physics of microfluids, specific methods of chemical synthesis of nanomaterials, and more. As the first book to discuss the unique properties and capabilities of these nanomaterials in the miniaturization of devices, this text serves as a one-stop resource for nanoscientists interested in microdevices. | |
|
PNAS November 9, 2004: Reprogrammable Microfluidic Devices (Proceedings of the National Academy of Sciences, v. 101, # 45) by National Academy of Sciences (Author) pp. 15825-16082 | |
|
|
Microbial detection in microfluidic devices through dual staining of quantum dots-labeled immunoassay and RNA hybridization [An article from: Analytica Chimica Acta] by Q. Zhang (Author), L. Zhu (Author), H. Feng (Author), S. Ang (Author), F.S. Chau (Author), Liu (Author) This digital document is a journal article from Analytica Chimica Acta, published by Elsevier in 2006. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser. Description: This paper reported the development of a microfludic device for the rapid detection of viable and nonviable microbial cells through dual labeling by fluorescent in situ hybridization (FISH) and quantum dots (QDs)-labeled immunofluorescent assay (IFA). The coin sized device consists of a microchannel and filtering pillars (gap=1-2@mm) and was demonstrated to effectively trap and concentrate microbial cells (i.e. Giardia lamblia). After sample injection, FISH probe solution and QDs-labeled antibody solution were... |
|
|
The enhanced diffusional mixing for latex immunoagglutination assay in a microfluidic device [An article from: Analytica Chimica Acta] by J.H. Han (Author), K.S. Kim (Author), J.Y. Yoon (Author) This digital document is a journal article from Analytica Chimica Acta, published by Elsevier in 2007. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser. Description: Latex immunoagglutination assay in a microfluidic device is expected to be even easier than its large-sized, commercialized counterpart. However, such demonstration has had a limited success due to the difficulties in mixing in a microfluidic device, especially for the microparticles used in latex immunoagglutination assay. The primary goal of this work is to improve diffusional mixing towards the successful latex immunoagglutination in a microfluidic devices without any non-specific binding. To this end, SDS... |
|
Microfluidic Devices in Nanotechnology Part II by Challa S. Kumar (Author) This is the first book to discuss the developments in microfluidics coupled with nanotechnology. This approach is a revolutionary way for growing numbers of investigations to replace, in the future, conventional synthesis of nanomaterials and nanomaterials-based analytical methods by lab-on-a-chip systems combining micro fluidic devices with nanotechnology. Exciting applications range from chemistry, biology, molecular and cell biology, neuroscience, catalysis and nanomaterial’s synthesis.. With reviews by world-recognized microflluidic and nanotechnology experts, this authoritative work provides strong scaffolding for futuristic applications utilizing synergy from two powerful scientific elements. | |
|
|
Integrated microfluidic devices [An article from: Analytica Chimica Acta] by D. Erickson (Author), D. Li (Author) This digital document is a journal article from Analytica Chimica Acta, published by Elsevier in 2004. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser. Description: ''With the fundamentals of microscale flow and species transport well developed, the recent trend in microfluidics has been to work towards the development of integrated devices which incorporate multiple fluidic, electronic and mechanical components or chemical processes onto a single chip sized substrate. Along with this has been a major push towards portability and therefore a decreased reliance on external infrastructure (such as detection sensors, heaters or voltage sources).'' In this review we provide an... |
| © 2009 BrightSurf.com |