 |
|
Seven UK cases of Creutzfeldt-Jakob disease associated with transplanted human tissue
April 20, 2006Dura mater-associated Creutzfeldt-Jakob disease: Experience from surveillance in the UK
Seven cases of Creutzfeldt-Jakob disease (CJD) associated with transplanted human tissue have occurred in the UK over a period of 33 years, reveals a study published ahead of print in the Journal of Neurology Neurosurgery and Psychiatry.
The seven cases of the fatal neurodegenerative disease were reported to the UK CJD surveillance system.
This monitors all cases of CJD arising sporadically, genetically, and as a result of infection from contaminated food products (variant form) or surgery (iatrogenic).
The seven cases reported between 1970 and 2003 were the result of inadvertent transmission via transplanted human dura mater.
Dura mater is the outermost, toughest, and most fibrous of the three membranes covering the brain and spinal cord. It is used in cranial and spinal surgical repair, and in various other procedures, such as the reinforcement of tendons and ligaments.
CJD arose between four and 15 years after surgery, and was traced to one particular supplier in six of the seven cases. In the remaining case, the source was traced to pig tissue, and is believed to be the first such case in the world.
The authors emphasise that transmission of CJD though the use of transplanted human dura mater is rare. Only 164 such cases have been identified around the globe, and most of these were treated with the product identified as the primary source in the UK cases.
The risk to patients in the UK is unknown, say the authors, but research from Australia puts the risk as high as 1 in 500 for those treated between 1973 and 2003.
In Japan, where some 20,000 human mater dura grafts are performed every year, the risk is put at between 1 in 1000 and 1 in 2000.
More stringent selection criteria and better disinfection techniques introduced since 1987 may help to reduce the numbers of future cases arising from surgical transplants, suggest the authors.
BMJ Specialty Journals
This monitors all cases of CJD arising sporadically, genetically, and as a result of infection from contaminated food products (variant form) or surgery (iatrogenic).
The seven cases reported between 1970 and 2003 were the result of inadvertent transmission via transplanted human dura mater.
Dura mater is the outermost, toughest, and most fibrous of the three membranes covering the brain and spinal cord. It is used in cranial and spinal surgical repair, and in various other procedures, such as the reinforcement of tendons and ligaments.
CJD arose between four and 15 years after surgery, and was traced to one particular supplier in six of the seven cases. In the remaining case, the source was traced to pig tissue, and is believed to be the first such case in the world.
The authors emphasise that transmission of CJD though the use of transplanted human dura mater is rare. Only 164 such cases have been identified around the globe, and most of these were treated with the product identified as the primary source in the UK cases.
The risk to patients in the UK is unknown, say the authors, but research from Australia puts the risk as high as 1 in 500 for those treated between 1973 and 2003.
In Japan, where some 20,000 human mater dura grafts are performed every year, the risk is put at between 1 in 1000 and 1 in 2000.
More stringent selection criteria and better disinfection techniques introduced since 1987 may help to reduce the numbers of future cases arising from surgical transplants, suggest the authors.
BMJ Specialty Journals
Creutzfeldt-Jakob Disease Current Events and Creutzfeldt-Jakob Disease News RSSThe Protein Srebp2 Drives Cholesterol Formation in Prion-Infected Neuronal Cells Which May Promote Prion-Dependent Diseases
The regulating protein Srebp2 drives cholesterol formation, which prions need for their propagation, in prion-infected neuronal cells.
Prion study reveals first direct information about the protein's molecular structure
A collaboration between scientists at Vanderbilt University and the University of California, San Francisco has led to the first direct information about the molecular structure of prions.
U of T led research team uncovers evolutionary origins of prion disease gene
A University of Toronto-led team has uncovered the evolutionary ancestry of the prion gene, which may reveal new understandings of how the prion protein causes diseases such as bovine spongiform encephalopathy (BSE), also known as "mad cow disease."
Species barrier may protect macaques from chronic wasting disease
Data from an ongoing multi-year study suggest that people who consume deer and elk with chronic wasting disease (CWD) may be protected from infection by an inability of the CWD infectious agent to spread to people.
Prevalence of variant CJD agent in Britain remains uncertain
First results from a large tissue survey in Britain of the agent that causes variant Creutzfeldt-Jakob disease (vCJD) are unable so far to establish that the prevalence is lower than that given by previous estimates, concludes a study published on bmj.com today.
Redefining what it means to be a prion
Whitehead Institute researchers have quintupled the number of identifiable prion proteins in yeast and have further clarified the role prions play in the inheritance of both beneficial and detrimental traits.
Iron is involved in prion disease-associated neuronal demise
Imbalance of iron homeostasis is a common feature of prion disease-affected human, mouse, and hamster brains, according to a new study by Dr. Neena Singh and colleagues at Case Western Reserve University School of Medicine, alongside collaborators from Creighton University.
Antibody key to treating variant CJD, scientists find
Scientists at the University of Liverpool have determined the atomic structure of the 'binding' between a brain protein and an antibody that could be key to treating patients with diseases such as variant CJD.
Give the foie gras a miss
Another reason not to eat pate de foie gras is discussed by Michael Greger of The Humane Society of the United States, Washington DC in a forthcoming issue of the International Journal of Food Safety, Nutrition and Public Health.
Mutant proteins result in infectious prion disease in mice
A worldwide group of scientists has created an infectious prion disease in a mouse model, in a step that may help unravel the mystery of this progressive disease that affects the nervous system in humans and animals.
More Creutzfeldt-Jakob Disease Current Events and Creutzfeldt-Jakob Disease News Articles
 |
Creutzfeldt-jakob Disease (Epidemics) by Phillip Margulies (Author) Traces the history, current issues, and future of Creutzfeldt-Jakob Disease, a rare genetic disorder that effects the brain and is part of the same group of illnesses as "mad cow disease." |
 |
Creutzfeldt-Jakob Disease: New Research by Michael J. Stonebrook (Editor) Creutzfeldt-Jakob Disease is a very rare and incurable degenerative neurological disorder that is ultimately fatal. It is the most common of the transmissible spongiform encephalopathies. Transmissible spongiform encephalopathy diseases (also known as prion diseases) are caused by a unique type of infectious agent called prions, an abnormally structured form of a protein found in the brain. Other prion diseases include Gerstmann-Straussler-Scheinker syndrome (GSS), fatal familial insomnia (FFI) and kuru in humans, as well as bovine spongiform encephalopathy (BSE) and scrapie in animals. This book presents the latest research in this field. |
|
UK blood service warns vCJD test could cut donations.(Creutzfeldt-Jakob disease)(Brief Article): An article from: Transplant News by Transplant Communications, Inc. (Publisher) This digital document is an article from Transplant News, published by Transplant Communications, Inc. on July 27, 2001. The length of the article is 583 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: UK blood service warns vCJD test could cut donations.(Creutzfeldt-Jakob disease)(Brief Article) Publication: Transplant News (Newsletter) Date: July 27, 2001 Publisher: Transplant Communications, Inc. Volume: 11 Issue: 14 Page: NA Article Type: Brief Article Distributed by Thomson... | |
|
vCJD risk from plasma very small.(NEWS FROM THE FDA)(variant Creutzfeldt-Jakob disease)(Brief article): An article from: Internal Medicine News by Unavailable (Author) This digital document is an article from Internal Medicine News, published by International Medical News Group on August 1, 2009. The length of the article is 320 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available immediately after purchase. You can view it with any web browser. Citation Details Title: vCJD risk from plasma very small.(NEWS FROM THE FDA)(variant Creutzfeldt-Jakob disease)(Brief article) Author: Unavailable Publication: Internal Medicine News (Magazine/Journal) Date: August 1, 2009 Publisher: International Medical News Group Volume: 42 Issue: 14 Page: 8(1) Article Type: Brief article Distributed by Gale, a part of Cengage... | |
|
Gale Encyclopedia of Nursing and Allied Health: Creutzfeldt-Jakob disease by Jr., MD, PhD, DrPH L. Fleming Fallon (Author) The article is excerpted from Gale Encyclopedia of Nursing and Allied Health. This 5-vol. set provides more than 850 entries covering topics in nursing and allied health written for students and professionals in the field. Alphabetically arranged entries cover topics in body systems and functions, conditions and common diseases, issues and theories, techniques and practices, and devices and equipment. The Encyclopedia covers all major health professions, including nursing, physical therapy, occupational therapy, respiratory therapy, medical lab technology, emergency medical technology, dental assistance, pharmacology and nutrition. In addition, the set features approximately 400 photographs and illustrations; appendices of related organizations, agencies and associations;... | |
|
Source of variant Creutzfeldt-Jakob disease outside United Kingdom.(RESEARCH): An article from: Emerging Infectious Diseases by Pascual Sanchez-Juan (Author), Simon N. Cousens (Author), Robert G. Will (Author), Cornelia M. van Duijn (Author) This digital document is an article from Emerging Infectious Diseases, published by Thomson Gale on August 1, 2007. The length of the article is 3001 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Source of variant Creutzfeldt-Jakob disease outside United Kingdom.(RESEARCH) Author: Pascual Sanchez-Juan Publication: Emerging Infectious Diseases (Magazine/Journal) Date: August 1, 2007 Publisher: Thomson Gale Volume: 13 Issue: 8 Page: 1166(4) Distributed by Thomson... | |
|
CREUTZFELDT-JAKOB DISEASE: An entry from Macmillan Reference USA's Encyclopedia of Aging by CHRIS MACKNIGHT (Author) As the Baby Boomers head toward retirement, the four-volume “Encyclopedia of Aging” offers a timely resource encompassing all aspects of aging. Covering a variety of disciplines—biology, medicine, economics, law, psychology, sociology and history—the Encyclopedia also explores related issues such as religion, spirituality, and ethics. | |
|
Early diagnosis of Creutzfeldt-Jakob disease by diffusion-weighted MRI.(Section on Internal Medicine): An article from: Southern Medical Journal by Jasmin Jerez-Marte (Author), Sarah Akhunji (Author), Jon M. Sweet (Author), Donald Nolan (Author), R. Wayne Gandee (Author), Russel H. Swerdlow (Author) This digital document is an article from Southern Medical Journal, published by Southern Medical Association on October 1, 2004. The length of the article is 374 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Early diagnosis of Creutzfeldt-Jakob disease by diffusion-weighted MRI.(Section on Internal Medicine) Author: Jasmin Jerez-Marte Publication: Southern Medical Journal (Refereed) Date: October 1, 2004 Publisher: Southern Medical Association Volume: 97 Issue: 10 Page: S20(2) Distributed by Thomson... | |
|
Protease-resistant prion protein in lymphoreticular tumors of variant Creutzfeldt-Jakob disease mice.(DISPATCHES): An article from: Emerging Infectious Diseases by Larisa Cervenakova (Author), Oksana Yakovleva (Author), Carroll McKenzie (Author) This digital document is an article from Emerging Infectious Diseases, published by Thomson Gale on March 1, 2006. The length of the article is 2075 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Protease-resistant prion protein in lymphoreticular tumors of variant Creutzfeldt-Jakob disease mice.(DISPATCHES) Author: Larisa Cervenakova Publication: Emerging Infectious Diseases (Magazine/Journal) Date: March 1, 2006 Publisher: Thomson Gale Volume: 12 Issue: 3 Page: 511(3) Distributed by Thomson... | |
 |
WHO Manual for Strengthening Diagnosis and Surveillance of Creutzfeldt-Jakob Disease by World Health Organization (Author) |
| © 2009 BrightSurf.com |