Science Current Events | Science News | Brightsurf.com
 

NYU, Austrian researchers create non-invasive imaging method with advantages over conventional MRI

April 25, 2006

New York University's Alexej Jerschow, an assistant professor of chemistry, and Norbert Müller, a professor of chemistry at the University of Linz in Austria, have developed a completely non-invasive imaging method. Their work offers the benefits of magnetic resonance imaging (MRI) while eliminating patients' exposure to irradiation and setting the stage for the creation of light, mobile MRI technology. The research, which appears in the latest issue of the Proceedings of the National Academy of Sciences (PNAS), was supported by the National Science Foundation.

MRI allows clinicians to non-invasively visualize soft tissue in the interior of the human body through the application of radiofrequency (rf) irradiation. However, the rf pulses of MRI machines deposit heat in patients and medical staff, though safety regulations that limit energy deposition have long been established. Jerschow and Müller have devised a low-energy, nuclear magnetic resonance (NMR) technique that does not require external rf-irradiation. Their technique, instead, relies on the detection of spontaneous, proton spin-noise in a tightly coupled rf-cavity.

In order to reconstruct spin-noise images that characterize MRI, the researchers used a commercial, liquid-state NMR spectrometer equipped with a cryogenically cooled probe. The sample, a phantom of four glass capillaries filled with mixtures of water and heavy water, remained at room temperature. The authors inserted the sample into a standard NMR tube and applied a magnetic field gradient to acquire spatial encoding information. They collected 30, one-dimensional images, and after applying a projection reconstruction algorithm, obtained the phantom's two-dimensional image. Because of its low-energy deposition, Müller and Jerschow's imaging technique may enable new application areas for magnetic resonance microscopy. Using already-developed methods, the researchers expect expansion to three-dimensional imaging to be straightforward.

The same detection scheme is applicable to NMR spectroscopy. Very delicate samples, such as explosives could be investigated with this method. Preliminary investigations also predict a sensitivity advantage over conventional experiments at length scales of millimeters to micrometers, which may be important in the measurement of NMR spectra within microfluidic devices.

Very strong magnetic fields, as generally required for MRI and NMR, can be avoided with the spin-noise detection scheme, making possible the development of extremely portable and minimally invasive MRI and NMR instruments.

New York University


Related Non-invasive Imaging Current Events and Non-invasive Imaging News Articles


Recent progress in tracking the viability of transplanted stem cells in vivo
Noninvasive cell-tracking methods are indispensable for assessing the safety and efficacy of stem-cell based therapy. Thus, the research of noninvasive cell-tracking methods for determining in vivo the translocation and long-term viability of the transplanted stem cells have received considerable attention.

Disappointing data for diabetes drug in the treatment of non-alcoholic fatty liver disease
New data presented today at The International Liver Congress™ 2016 in Barcelona, Spain, demonstrates that the drug sitagliptin - more commonly used to treat diabetes - was no more effective than placebo for reducing non-alcoholic fatty liver disease (NAFLD).

How a waste product of exercise protects neurons from trauma damage
Researchers led by EPFL have found how lactate, a waste product of glucose metabolism can protect neurons from damage following acute trauma such as stroke or spinal cord injury.

CLAIRE brings electron microscopy to soft materials
Soft matter encompasses a broad swath of materials, including liquids, polymers, gels, foam and - most importantly - biomolecules. At the heart of soft materials, governing their overall properties and capabilities, are the interactions of nano-sized components.

New light for old master paintings
A painting hanging on the wall in an art gallery tells one story. What lies beneath its surface may tell quite another.

Novel imaging technique improves prostate cancer detection
In 2014, prostate cancer was the leading cause of newly diagnosed cancers in men and the second leading cause of cancer death in men.

Customising chemotherapy in Lu Ca: New Ph II data reported in 2 LB studies
Measuring the expression levels of an enzyme involved in DNA synthesis can help predict the response of lung cancers to certain treatments, a Korean study has shown at the ESMO 2014 Congress in Madrid.

Imaging autoimmune diabetes
Researchers at Lund University have managed to develop a technique whereby they can study the inflammatory process that takes place in the pancreas during the natural development of type 1 diabetes, allowing for real time and repeated non-invasive imaging of individual islets of Langerhans.

Your first hug: how the early embryo changes shape
In research published today in Nature Cell Biology, scientists from the EMBL Australia research team based at Monash University's Australian Regenerative Medicine Institute (ARMI) have revealed new insights into how cells organise and form an early mammalian embryo.

Imaging technique detects pediatric liver disease without need for needle biopsy
A new, non-invasive imaging technique, magnetic resonance elastography (MRE), can now help physicians accurately detect fibrosis (scarring) in children with chronic liver disease - a growing problem due in part to increasing obesity rates.
More Non-invasive Imaging Current Events and Non-invasive Imaging News Articles

Non Invasive Diagnostic Techniques in Clinical Dermatology

Non Invasive Diagnostic Techniques in Clinical Dermatology
by Enzo Berardesca (Editor), Howard Maibach (Editor), Klaus Wilhelm (Editor)


This book is a comprehensive but compact guide to the latest technical and technological developments in the growing field of non invasive diagnosis in clinical dermatology. Information is provided on the practical and technical characteristics of a wide range of equipment and methods for in vivo measurements that aid in the investigation of skin function, the evaluation of topically applied products and the monitoring of skin disease. Individual sections are devoted to imaging techniques, skin analysis, superficial skin analysis, skin mechanics, water and stratum corneum hydration and erythema and blood flow. All of the authors are experts in the field, with detailed knowledge of the techniques they describe. Non Invasive Diagnostic Techniques in Clinical Dermatology will be of value for...

Quality Evaluation in Non-Invasive Cardiovascular Imaging

Quality Evaluation in Non-Invasive Cardiovascular Imaging
by Peter L. Tilkemeier (Editor), Robert C. Hendel (Editor), Gary V. Heller (Editor), James A. Case (Editor)


This handbook provides hospitals, clinics, and imaging centers, along with their medical and technical directors and hospital administrators, with the necessary information and tools to develop quality initiatives.  The specific aims of this book include:  1.Describe quality control as it relates to non-invasive cardiovascular imaging                                                                      2.Understand the current standards as published by societal guidelines or accrediting organizations e.g. American College of Radiology (ACR), Intersocietal Accreditation Commission (IAC), The Joint Commission (TJC) or the European Society of Cardiology (ESC). 3.Demonstrate techniques to comply with the routine...

Electromyography: Physiology, Engineering, and Non-Invasive Applications

Electromyography: Physiology, Engineering, and Non-Invasive Applications
by Roberto Merletti (Editor), Philip J. Parker (Editor)


A complete overview of electromyography with contributions from pacesetters in the field In recent years, insights from the field of engineering have illuminated the vast potential of electromyography (EMG) in biomedical technology. Featuring contributions from key innovators working in the field today, Electromyography reveals the broad applications of EMG data in areas as diverse as neurology, ergonomics, exercise physiology, rehabilitation, movement analysis, biofeedback, and myoelectric control of prosthesis. Bridging the gap between engineering and physiology, this pioneering volume explains the essential concepts needed to detect, understand, process, and interpret EMG signals using non-invasive electrodes. Electromyography shows how engineering tools such as models and signal...

Dual-Energy CT in Cardiovascular Imaging

Dual-Energy CT in Cardiovascular Imaging
by Patricia M. Carrascosa (Editor), Ricardo C. Cury (Editor), Mario J. García (Editor), Jonathon A. Leipsic (Editor)


This is the first textbook in DECT focussing especially on the cardiovascular field. DECT was developed many years ago but has recently spread its clinical utility. Many new applications have been developed over the last years and the cardiovascular system has benefited from these advances. New protocols will be used in the near future which will help to optimize results obtained until now with single energy CT, such as a more precise quantification of coronary artery stenosis using either different monochromatic levels or material decomposition, reduction of beam hardening artifacts in perfusion studies and optimizing endovenous contrast, among others.​

Handbook of Non-Invasive Methods and the Skin, Second Edition

Handbook of Non-Invasive Methods and the Skin, Second Edition
by Jorgen Serup (Editor), Gregor B. E. Jemec (Editor), Gary L. Grove (Editor)


Firmly established as the leading international reference in this field, Non-Invasive Methods and the Skin broke new ground with its comprehensive coverage of methods used in both clinical and experimental dermatology. Completely revised and updated, containing more than twice as much information, the Second Edition continues the tradition. The authors' thorough research and clear organization make this book a baseline reference for those using noninvasive biophysical methods to study the skin.

Arranged by physical modality and structured to provide educational and practical information, the second edition, like its predecessor, will prove to be of value to young researchers and senior scientists alike. The coverage of major evaluation and measurement methods share a consistent...

Atlas of Non-Invasive Coronary Angiography by Multidetector Computed Tomography (Developments in Cardiovascular Medicine)

Atlas of Non-Invasive Coronary Angiography by Multidetector Computed Tomography (Developments in Cardiovascular Medicine)
by Guillem Pons-Llado (Editor), Ruben Leta-Petracca (Editor)


This atlas presents over 160 illustrations, with 116 in color, and illustrates the capacity of multidetector CT for the analysis of the anatomy of the coronary arteries. The multidetector CT scanner speeds diagnosis and treatment of patients. One of its many uses is to perform CT coronary angiography. Multidetector CT provides clear pictures and takes less time than other non-invasive techniques. The book is written by cardiologists and radiologists.

Practical Phlebology: Venous Ultrasound

Practical Phlebology: Venous Ultrasound
by Joseph Zygmunt (Author), Olivier Pichot (Author), Tracie Dauplaise (Author)


Authored by three of the leading world experts in phlebology, Venous Ultrasound is an essential text for anyone involved in the treatment of chronic venous disease. It provides specific information on ultrasound as it is applied to chronic insufficiency, including history, general techniques, examples of anatomy, and protocols for performing ultrasound on patients. Focusing on the fundamentals that every phlebologist needs to know, the book includes color illustrations and numerous line drawings for a complete learning experience. Key features: • Covers anatomy related to venous insufficiency • Includes useful diagrams and images to aid understanding • Thoroughly up to date, with all the latest information for those practicing venous therapies Venous Ultrasound will be invaluable...

Imaging for Students Fourth Edition

Imaging for Students Fourth Edition
by David A. Lisle (Author)


Imaging for Students delivers step-by-step guidance to the range of imaging techniques available, providing a clear explanation of how each imaging modality actually works, and including information on the associated risks and hazards. Throughout, the importance of patient preparation and post-procedure observation is emphasized. Taking information from evidence-based studies and published guidelines, in line with current clinical practice, the book takes a highly logical approach to the investigation of clinical scenarios, where possible indicating the "best first test"―vital to both appropriate clinical and cost-effective decision-making. Drawing on the extensive clinical and teaching experience of its respected author, the fourth edition of Imaging for Students gives students and...

Targeted Molecular Imaging (Imaging in Medical Diagnosis and Therapy)

Targeted Molecular Imaging (Imaging in Medical Diagnosis and Therapy)
by Michael J. Welch (Editor), William C. Eckelman (Editor)


Targeted Molecular Imaging covers the development of novel diagnostic approaches that use an imaging probe and agent to noninvasively visualize cellular processes in normal and disease states. It discusses the concept, development, preclinical studies, and, in many cases, translation to the clinic of targeted imaging agents. The many case studies that form the core of this book deal with the development and translation of non-nuclear probes and radiotracers; other sections address critical topics such as In vitro studies, small animal research, and the application of targeted probes for nuclear, optical and MRI imaging. The chapters use a common format to demonstrate how various investigators approach the comprehensive task of validating a new targeted probe. Targeted Molecular Imaging...

Multi-substance Non-invasive 3d Imaging by 2 or 3 Stationary Instrument Sets, with Internal Neutron Activation and External Modulation of Neutrons and Scattered Gammas (INA/MENG)

Multi-substance Non-invasive 3d Imaging by 2 or 3 Stationary Instrument Sets, with Internal Neutron Activation and External Modulation of Neutrons and Scattered Gammas (INA/MENG)


PART 1. Outlines notions, terms, and procedures employed in the analysis. PART 2. Solves 3d imaging using two neutron sources, each with a modulator. PART 3. Renders two imaging solutions using one neutron source and its modulator, both vibrating in situ

© 2016 BrightSurf.com