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Protective action of a molecule in inflammatory processes discovered
April 27, 2006Henar Hevia Pérez, researcher in the area of Genic Therapy and Hepatology at the Applied Medicine Research Centre (CIMA)of the University of Navarra, has discovered the protective role of the methylthioadenosine (MTA) molecule in an in vivo inflammation model. The doctor has recently defended her PhD thesis at the Faculty of Sciences.
According to the biochemist, the inflammatory component is key in the development of many diseases, including those affecting the liver and, therefore, of vital importance in creating new therapeutic strategies aimed at mitigating their effects.
Besides many other functions, the liver plays an essential role in the metabolism of aminoacids, amongst which are metionine, an essential aminoacid and the metabolism of which is altered in hepatic diseases such as cirrhosis and liver cancer. As a result, the focus of the researchers for some time has been the study of the hepatic metabolism of this aminoacid and the pathological consequences of its alteration.
Inflammation associated with liver pathologies
Dr. Henar Hevia studied the role of an important metabolic derivative of metionine, MTA, in inflammation, a process associated with a great variety of pathologies, including liver damage. These studies were undertaken in both in vivo and in vitro models and, in all of these, the potent anti-inflammatory effect of MTA could be verified. The researcher argues that the administration of MTA prevented the development of the acute inflammatory response and thereby completely protected the test animals against death. Moreover, prolonged treatment with MTA turned out to be quite tolerant and never produced adverse reactions in the animals.
In her opinion, this research by CIMA at the University of Navarra suggests that the administration of MTA could turn out to be effective in the treatment of diseases that have an inflammatory component such as hepatic cirrhosis, arthritis or multiple sclerosis.
Elhuyar Fundazioa
Inflammation associated with liver pathologies
Dr. Henar Hevia studied the role of an important metabolic derivative of metionine, MTA, in inflammation, a process associated with a great variety of pathologies, including liver damage. These studies were undertaken in both in vivo and in vitro models and, in all of these, the potent anti-inflammatory effect of MTA could be verified. The researcher argues that the administration of MTA prevented the development of the acute inflammatory response and thereby completely protected the test animals against death. Moreover, prolonged treatment with MTA turned out to be quite tolerant and never produced adverse reactions in the animals.
In her opinion, this research by CIMA at the University of Navarra suggests that the administration of MTA could turn out to be effective in the treatment of diseases that have an inflammatory component such as hepatic cirrhosis, arthritis or multiple sclerosis.
Elhuyar Fundazioa
Inflammation Current Events and Inflammation News RSSMultiple health concerns surface as winter, vitamin D deficiences arrive
A string of recent discoveries about the multiple health benefits of vitamin D has renewed interest in this multi-purpose nutrient, increased awareness of the huge numbers of people who are deficient in it, spurred research and even led to an appreciation of it as "nature's antibiotic."
Surface bacteria maintain skin's healthy balance
On the skin's surface, bacteria are abundant, diverse and constant, but inflammation is undesirable. Research at the University of California, San Diego School of Medicine now shows that the normal bacteria living on the skin surface trigger a pathway that prevents excessive inflammation after injury.
Toward explaining why hepatitis B hits men harder than women
Scientists in China are reporting discovery of unusual liver proteins, found only in males, that may help explain the long-standing mystery of why the hepatitis B virus (HBV) sexually discriminates -- hitting men harder than women.
Women at risk from vitamin A deficiency
Almost half of UK women could be suffering from a lack of vitamin A due to a previously undiscovered genetic variation, scientists at Newcastle University have found.
Can EP4 agonist alleviate gastric lesions?
Over 300 million patients use non-steroidal anti-inflammatory drugs (NSAIDs) in the world to treat pain, arthritis, fever and other diseases. Nearly 30% of the users suffer from gastric lesions and bleeding.
Immune system activated in schizophrenia
Researchers at the Swedish medical university Karolinska Institutet have discovered that patients with recent-onset schizophrenia have higher levels of inflammatory substances in their brains. Their findings offer hope of being able to treat schizophrenia with drugs that affect the immune system.
Largest gene study of childhood IBD identifies 5 new genes
In the largest, most comprehensive genetic analysis of childhood-onset inflammatory bowel disease (IBD), an international research team has identified five new gene regions, including one involved in a biological pathway that helps drive the painful inflammation of the digestive tract that characterizes the disease.
Tiny particles can deliver antioxidant enzyme to injured heart cells
Researchers at Emory University and the Georgia Institute of Technology have developed microscopic polymer beads that can deliver an antioxidant enzyme made naturally by the body into the heart.
New study links vitamin D deficiency to cardiovascular disease and death
While mothers have known that feeding their kids milk builds strong bones, a new study by researchers at the Heart Institute at Intermountain Medical Center in Salt Lake City suggests that Vitamin D contributes to a strong and healthy heart as well - and that inadequate levels of the vitamin may significantly increase a person's risk of stroke, heart disease, and death, even among people who've never had heart disease.
Aileron collaborates study in Nature: Stapled peptides inhibit Notch1 transcription factor
This research validates the potential for Stapled Peptides to modulate key intracellular biological targets, such as transcription factors, that have not been addressable with current small molecule or biologic drug modalities.
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