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Gene variations linked to brain aneurysms
April 27, 2006The interleukin-6 gene -174G>C and -572G>C promoter polymorphisms are related to cerebral aneurysms. Online First J Neurol Neurosurg Psychiatry 2006 doi 10.1136/jmmp.2005.081976
Variations in a gene seem to be linked to brain (cerebral) aneurysms, suggests research published ahead of print in the Journal of Neurology Neurosurgery and Psychiatry.
Brain aneurysms occur when a section of an artery bulges, often at a stress point, such as a branch or a bend. This weakens the wall and makes it prone to rupture and the discharge of blood into other areas of the brain.
The condition may affect up to 8% of the population, but inflammation is thought to have a key role.
The research team analysed the frequency of two variations of a gene responsible for the production of a potent chemical involved in inflammation among 91 people with an unruptured brain aneurysm and 2720 healthy people matched for age and race.
Interleukin-6 or IL-6 for short is involved in the inflammatory processes of coronary artery disease and has been implicated in stroke and an increased risk of dementia. The chemical is known to damage brain tissue.
The frequency of a particular variation of the Il-6 gene (-572G>C ), which boosts production of the chemical, was around 14 times more common among the patients with aneurysm than among the comparison group.
Similarly, another variation (-174G>C), which suppresses the production of Il-6, was around 2.5 times as common among the comparison group as it was among the patients with aneurysm.
As yet, it is not known at whether these variations come into play at the development, progression, or rupture stages, say the authors, but there appears to be a clear link between them and brain aneurysms.
BMJ Specialty Journals
The condition may affect up to 8% of the population, but inflammation is thought to have a key role.
The research team analysed the frequency of two variations of a gene responsible for the production of a potent chemical involved in inflammation among 91 people with an unruptured brain aneurysm and 2720 healthy people matched for age and race.
Interleukin-6 or IL-6 for short is involved in the inflammatory processes of coronary artery disease and has been implicated in stroke and an increased risk of dementia. The chemical is known to damage brain tissue.
The frequency of a particular variation of the Il-6 gene (-572G>C ), which boosts production of the chemical, was around 14 times more common among the patients with aneurysm than among the comparison group.
Similarly, another variation (-174G>C), which suppresses the production of Il-6, was around 2.5 times as common among the comparison group as it was among the patients with aneurysm.
As yet, it is not known at whether these variations come into play at the development, progression, or rupture stages, say the authors, but there appears to be a clear link between them and brain aneurysms.
BMJ Specialty Journals
Brain Aneurysms Current Events and Brain Aneurysms News RSSNew treatment option for ruptured brain aneurysms
Researchers in Finland have identified an effective new treatment option for patients who have suffered a ruptured brain aneurysm, a potentially life-threatening event. Results of the new study on stent-assisted coil embolization were published today in the online edition of Radiology.
Minimally invasive stroke treatment produces better patient outcomes than surgical operation
While minimally invasive coil treatments for those with a ruptured brain aneurysm have proved to be a more effective technique than traditional surgical operation in selected patients, the superior procedure is drastically more expensive.
Routine Testing After Aneurysm Coiling Carries Low Risk
A very low risk of complication is associated with a routine test that determines whether a brain aneurysm treated with endovascular coiling has started to recur, a study led by the University of Cincinnati Neuroscience Institute has shown.
Yale researchers unravel mystery of brain aneurysms
Yale researchers have taken the first critical steps in unraveling the mysteries of brain aneurysms, the often fatal rupturing of blood vessels that afflicts 500,000 people worldwide each year and nearly killed Vice President-elect Joseph Biden two decades ago.
Rapid changes in key Alzheimer's protein described in humans
For the first time, researchers have described hour-by-hour changes in the amount of amyloid beta, a protein that is believed to play a key role in Alzheimer's disease, in the human brain.
Preclinical Study Links Gene to Brain Aneurysm Formation
University of Cincinnati (UC) neurovascular researchers have identified a gene that-when suppressed or completely absent-may predispose a person to brain aneurysms.
Results of clipping and coiling of aneurysms are similar over time
A study led by UCSF neurologist S. Claiborne Johnston, MD, has shown that coiling of ruptured brain aneurysms is very effective during long-term follow-up, similar to outcomes with surgical clipping.
Polycystic kidney disease: MRI provides an early alert to progression
A new method using magnetic resonance imaging (MRI) accurately tracks structural changes that predict functional changes earlier than standard blood and urine tests in people with autosomal dominant polycystic kidney disease (PKD).
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