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Blood clots may hold key to treating dementia
April 28, 2006Cerebral emboli as a potential cause of Alzheimer's disease and vascular dementia: Case-control study; BMJ online first
Spontaneous blood clots or debris from arterial disease in the brain (known as cerebral emboli) may hold the key to preventing or treating dementia, say researchers from the University of Manchester in this week's BMJ.
They monitored the occurrence of spontaneous cerebral emboli in 170 patients with dementia (85 with Alzheimer's disease, 85 with vascular dementia) and 150 controls of the same sex and age.
They detected cerebral emboli in 32 (40%) of patients with Alzheimer's disease and 31 (37%) of those with vascular dementia in only one hour of monitoring, compared with just 12 each (15% and 14%) of their controls. This suggests that both types of dementia have more in common than we've thought before, say the authors.
This study is the first of this type and more research is needed, but the authors conclude that spontaneous cerebral emboli are significantly associated with both Alzheimer's disease and vascular dementia and may represent a potentially preventable or treatable cause of both types of dementia.
BMJ-British Medical Journal
Dementia Current Events and Dementia News RSSSurgery not linked to memory problems in older patients
For years, it has been widely assumed that older adults may experience memory loss and other cognitive problems following surgery. But a new study from researchers at Washington University School of Medicine in St. Louis questions those assumptions.
Cognitive dysfunction reversed in mouse model of Down syndrome
A study by neuroscientist William C. Mobley, MD, PhD, chair of the Department of Neurosciences at the University of California, San Diego School of Medicine, and colleagues at Stanford University Medical School has demonstrated a possible new approach to slowing the inevitable progression of cognitive decline found in Down's syndrome.
Brain injured athletes may benefit from hypothermia research
NFL players and other athletes who suffer serious or multiple concussions may benefit from ground-breaking research being conducted by scientists at Barrow Neurological Institute at St. Joseph's Hospital and Medical Center. The scientists are developing a surgical technique that involves hypothermia in specific regions of the brain.
Neuroimaging provides insights into new treatment options for Alzheimer's disease
With about 35 million people around the world suffering from Alzheimer's disease (AD) by the year 2010 and an expectation that these numbers will double every twenty years with approximately 115 million cases by 2050, pressure on healthcare systems worldwide will be intense.
Reduced muscle strength associated with risk for Alzheimer's
Individuals with weaker muscles appear to have a higher risk for Alzheimer's disease and declines in cognitive function over time, according to a report in the November issue of Archives of Neurology, one of the JAMA/Archives journals.
Amyloid beta protein gets bum rap
While too much amyloid beta protein in the brain is linked to the development of Alzheimer's disease, not enough of the protein in healthy brains can cause learning problems and forgetfulness, Saint Louis University scientists have found.
Blood test identifies women at risk from Alzheimer's
Middle-aged women with high levels of a specific amino acid in their blood are twice as likely to suffer from Alzheimer's many years later, reveals a thesis from the Sahlgrenska Academy at the University of Gothenburg, Sweden.
Estrogen therapy likely must be given soon after menopause to provide stroke protection
For estrogen replacement to provide stroke protection, it likely must be given soon after levels drop because of menopause or surgical removal of the ovaries, scientists report in the Journal of Neuroscience.
Biofield therapies: helpful or full of hype?
Biofield therapies, which claim to use subtle energy to stimulate the body's healing process, are promising complementary interventions for reducing the intensity of pain in a number of conditions, reducing anxiety for hospitalized patients and reducing agitated behaviors in dementia, over and above what standard treatments can achieve.
Benefit of memantine in the treatment of Alzheimer's disease not proven
There is no scientific proof that patients with moderate or severe Alzheimer's disease benefit from drugs containing the agent memantine.
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