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FDG-PET accurate for evaluating lung tumor destruction from radiofrequency ablation
May 01, 2006FDG-PET can be used to assess the amount of tumor destruction after radiofrequency ablation (RFA)-the use of heat to destroy tumors-for the treatment of lung tumors and may provide more valuable information than CT alone, according to a new study.
For the study, researchers assessed 10 tumors in 10 patients who had lung tumors treated with CT-guided RFA and had PET scans both prior to RFA and following RFA. The researchers found that in seven out of 11 RFA treatments for the 10 patients, follow-up PET demonstrated persistent tumor activity. Two of the patients showed no activity on the follow-up PET, suggesting complete destruction of any active tumor. One patient had no definite change in the appearance of the mass, and another had a smaller lesion on follow-up PET.
"Usually, CT is used to assess tumor destruction, but CT cannot tell you whether a tumor is still alive-that is, actively metabolizing glucose-or dead in the area of destruction. It can also be difficult to assess how much of the ablated area is caused by an inflammatory reaction to the procedure. By using PET, the tumor cells that are still alive light up and the radiologist can better assess how much residual active tumor is left," said Jennifer Daly, MD, of the Newton-Wellesley Hospital in Newton, MA, and lead author of the study.
According to the researchers, without effective follow-up imaging, the radiologist has to gauge how successful it was based only on the patient's improvement in pain and maybe what is possibly seen on a post-ablation CT. "You don't really know for sure how much active tumor is destroyed unless you compare pre- and post-PET scans," said Dr. Daly.
The full results of the study will be presented on Monday, May 1, 2006 during the American Roentgen Ray Society Annual Meeting in Vancouver, BC.
American Roentgen Ray Society
According to the researchers, without effective follow-up imaging, the radiologist has to gauge how successful it was based only on the patient's improvement in pain and maybe what is possibly seen on a post-ablation CT. "You don't really know for sure how much active tumor is destroyed unless you compare pre- and post-PET scans," said Dr. Daly.
The full results of the study will be presented on Monday, May 1, 2006 during the American Roentgen Ray Society Annual Meeting in Vancouver, BC.
American Roentgen Ray Society
Lung Tumor Current Events and Lung Tumor News RSSLung cancer suppresses miR-200 to invade and spread
Primary lung cancer shifts to metastatic disease by suppressing a family of small molecules that normally locks the tumor in a noninvasive state, researchers at The University of Texas M. D. Anderson Cancer Center report in the Sept. 15 edition of Genes and Development.
Small peptide found to stop lung cancer tumor growth in mice
In new animal research done by investigators at Wake Forest University School of Medicine, scientists have discovered a treatment effective in mice at blocking the growth and shrinking the size of lung cancer tumors, one of the leading causes of cancer death in the world.
Molecule Plays Early Role In Nonsmoking Lung Cancer
The cause of lung cancer in never-smokers is poorly understood, but a study led by investigators at the Ohio State University Comprehensive Cancer Center and at the National Cancer Institute has identified a molecule believed to play an early and important role in its development.
Vaporized viral vector shows promise in anti-cancer gene therapy
A new lung cancer therapy employing a vaporized viral vector to deliver a cancer-inhibiting molecule directly to lung tissue shows early promise in mouse trials, according to researchers at the Ministry of Education, Science and Technology in Korea.
New findings measure precise impact of fat on cancer spread
Researchers at Purdue University have precisely measured the impact of a high-fat diet on the spread of cancer, finding that excessive dietary fat caused a 300 percent increase in metastasizing tumor cells in laboratory animals.
Genome study charts genetic landscape of lung cancer
An international team of scientists today announced the results of a systematic effort to map the genetic changes underlying lung cancer, the world's leading cause of cancer deaths.
Study identifies novel gene alterations in lung cancer
An international team of scientists, supported in part by the National Human Genome Research Institute (NHGRI), one of the National Institutes of Health (NIH), today announced that its systematic effort to map the genomic changes underlying lung cancer has uncovered a critical gene alteration not previously linked to any form of cancer.
Genomic profiling of lung tumors helps doctors choose most effective treatment
Determining the genetic profile of a particular lung tumor can help clinicians make the crucial decision about which chemotherapy treatment to try first.
Multicenter study nets new lung tumor-suppressor gene
Collaborating scientists in Boston and North Carolina have found that a particular gene can block key steps of the lung cancer process in mice.
Ireland Cancer Center researchers advance lung cancer treatment
Researchers at the Ireland Cancer Center of University Hospitals Case Medical Center have developed methods for treating lung cancer cells that have become resistant to new anti-cancer agents.
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Balanceuticals Stomach Fortifier Dietary Supplement Capsules, 500 mg, 60-Count Bottles (Pack of 2) by Balanceuticals Dietary supplement. 100% Natural. Made under supervision by China Academy of Traditional Chinese Medicine. This well-known formula is made of ginseng root, poria (Indian bread), attractylodes, common yam, hyacinth bean, coix, ammonium seed, platcodon and licorice. Chinese medicine uses it to strengthen the spleen and stomach, normalize peristalsis of the stomach and intestines, promote absorption of water and chlorine ion, improve metabolism, nurture the lung, balance bowel movements and increase energy. (This statement has not been evaluated by the FDA. This produc is not intended to diagnose, treat, cure of prevent any disease.) |
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Cancer Be Gone Guided imagery CD taps into the immense power of the mind to enhance comfort, healing, an optimistic attitude and positive expectations. Metaphor of "cancer as weeds in a garden that are easily managed". |
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Pathology of Lung Tumors (Contemporary Issues in Surgical Pathology) by B. Corrin (Editor) London Univ., U.K. Text describing new developments in the field of lung tumors and tumor-like conditions. 34 contributors, 4 U.S. Halftone and color illustrations. Extensive references. |
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Early Detection and Localization of Lung Tumors in High Risk Groups (Handbook of Experimental Pharmacology) by P. R. Band (Other Contributor) | |
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